Ultrastructure of the Antigen-retaining Reticulum of Lymph Node Follicles as shown by High-resolution Autoradiography

Effects of X‐irradiation on Antigen Localization in Lymphoid Follicles

“…Some degree of follicular localization persisted with doses up to 1850 R. and, as 450 R destroyed virtually all the lymphoeytes in the node, this substantiates the viewpoint (Mitchell and Abbot, 1965) that follicular antigen is not simply attached to the surface of lymphocytes. In fact, it is located in association with processes of reticular cells, and these are known to be relatively radioresistant.…”

Morphological and immunological definition of a malignant lymphoma derived from germinal-centre cells with cleaved nuclei (centrocytes)

“…In 12/20 isomorphic cases, dendritic reticulum cells were demonstrable among the tumour cells. Dendritic reticulum cells appear to be restricted to the lymphnode cortex, in which the germinal-centre reaction takes place (Milanesi, 1965;Mitchell & Abbot, 1965;Nossal et al, 1968;Lennert & Niedorf, 1969;Veldman, 1970).…”

Effects of the Lymphocytosis-Promoting Factor of Bordetella Pertussis on Antibody Production in Mice

“…Moreover, evidences have been accumulated showing that reticular cells or macrophages in the lymphoid follicles play a role in the transfer of antigen information to immunocompetent cells. Nossal, Ada and Austin (1964), Nossal (1967), Nossal et al (1968) and Mitchell and Abbot (1965) suggested, from their autoradiographic studies on the antigen localization in rats, the importance of the close contact of small lymphocytes to reticular cells within lymphoid follicles in the initiation of antibody production.…”