Effects of the Lymphocytosis-Promoting Factor of Bordetella Pertussis on Antibody Production in Mice

Effects of the Lymphocytosis-Promoting Factor From Bordetella Pertussis on the Function and Potentiality of Lymphocytes

“…Recently it was reported from this laboratory that LPF suppressed the antibody responses of mice to sheep red cells and tetanus toxoid when inoculated prior to antigens (Asakawa, 1969). Whether such immunosuppressive effects of LPF are closely related with the above-mentioned alternation of lymphocytes are also under investigation.…”

“…1), about one day earlier than in mice which showed the peak response 3 to 4 days after LPF inoculation (Iwasa et al, 1966, 1968, Asakawa, 1969. Polymorphonuclear leukocytes also increased, particularly at larger doses, but to a lesser extent than did lymphocytes.…”

“…The polymorphonuclear leukocytes response of rats to LPF, however, appeared to be more intensive than that of mice (Iwasa et al, 1966, 1968, Asakawa, 1969.…”

Standardization of Tetanus Toxoid Combined With Pertussis Vaccine

“…(1) First of all, the difference in the adjuvant effect of pertussis vaccine between animal species should be considered. Pertussis vaccine contains not only substances showing adjuvance (Farthing and Holt, 1962) but also principles inhibitory to antitoxin production occasionally (Asakawa, 1969). Those substances may modify the antitoxin production in different ways and their action may be different depending on the animal species.…”

The Effect of Bordetella Pertussis Lymphocytosis-Promoting Factor (Lpf) on Antibody Response in Mice: Its Enhancing and Suppressive Effects

“…In these reports, however, conflicting results were given in respect to the effect of LPF on antibody response in mice. Asakawa (1969) demonstrated that antibody response of mice to SRBC and tetanus toxoid was suppressed by inoculation of LPF prior to the antigen, whereas some other workers observed an increased antibody response when LPF was mixed with the antigen or given before the administration of antigen. It is possible that the above contradictions may have been due to some different experimental conditions used by them.…”