Ultrastructure of the polymorphonuclear leucocytes in human immunodeficiency virus infection

Battaglione, V.; Fischer, Florence; Michiels, Jean‐François; Rossi, Bernard; Hofman, Paul

doi:10.1080/003130200104367

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…De la même façon, de nombreuses maladies dégénératives (élastopathies, connectivites, certaines neuropathies), de surcharge (amylose), ou métaboliques (glycogénoses, dyslipoïdoses) ont été initialement identifiées par des observations ultrastructurales [1]. Enfin, des agents pathogènes, en particulier viraux, mais aussi bactériens, parasitaires ou mycotiques, ainsi que les conséquences cellulaires de leurs infections ont été identifiés et caractérisés grâce à la ME [2,3]. L'arrivée des techniques d'immuno-histochimie (IHC) et de biologie moléculaire (BM) a révolutionné l'approche diagnostique en pathologie depuis un peu plus d'une vingtaine d'années.…”

Section: Introductionunclassified

Que reste t-il de la microscopie électronique pour le diagnostic anatomopathologique en 2010 ?

Mari

Hofman

Butori

et al. 2010

Annales de Pathologie

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In the last decades, several ancillary methods, such as immunohistochemistry and molecular biology techniques, have increased the possibilities for the diagnosis and to evaluate the prognosis of lesions observed in a laboratory of pathology. Conversely, the impact of another method largely used a couple of years ago in a laboratory of pathology, the electron microscopy (EM), is currently limited. EM is a difficult, quite expensive and long method, which requires technicians with a high qualification. Therefore, EM is currently rarely available at the hospital in a laboratory of pathology and is essentially established in research centers. However, EM is still an essential tool for the surgical pathologist. This method allows in some circumstances to confirm or, more rarely, to make the diagnosis of a couple of tissular and cellular lesions observed in human pathology. EM is also an interesting method to better understand the etiopathogenesis of emerging human diseases, in particular of emerging infectious diseases. In this review, we report the main indication of EM in human pathology, we lay special emphasize in certain infectious diseases and neoplasia.

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Section: Introductionunclassified

Que reste t-il de la microscopie électronique pour le diagnostic anatomopathologique en 2010 ?

Mari

Hofman

Butori

et al. 2010

Annales de Pathologie

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Aspects histopathologiques de l'infection par le VIH

Hofman

2007

Revue Francophone des Laboratoires

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Tubuloreticular Structures in Rectal Biopsies of SIV-infected Rhesus Monkeys (Macaca mulatta)

Kaup¹,

Bruno²,

Mätz‐Rensing³

et al. 2005

Ultrastructural Pathology

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Tubuloreticular structures (TRS) are considered to be a specific ultrastructural marker for AIDS in various organs. Experimental SIV infection in rhesus macaques is the most appropriate animal model of HIV infection. In 8 rhesus monkeys, experimentally infected with SIVmac251/MPBC, rectum biopsies were taken prior to and post infection (day 3; 1, 2, 4, 12 weeks p.i.) and were investigated by transmissionelectron microscopy to determine incidence and extent of tubuloreticular structures as well as affected cells. From the first week p.i. on TRS were found in all experimental animals as tubuli with a diameter of 20-30 nm. The tubuli were arranged in regular paracristalline formations and formed intracytoplasmatic heterogenous, polymorph accumulations, which were localized close to the endoplasmatic reticulum. In the rectal lamina propria macrophages, endothelial cells, plasma cells, lymphocytes, fibroblasts, and neutrophilic granulocytes were the affected cell types. In 5 control biopsies TRS were detected, too, but, in contrast to SIV-infected animals, they appeared only singular and very small. The results indicate that TRS are a characteristic morphologic criteria of intestinal SIV infection. They appear in very early stages of the infection. In the rectum, they can be detected as bigger, conspicuous, and abundant formations in several cells and have a restricted diagnostic and prognostic validity.

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Ultrastructure of the polymorphonuclear leucocytes in human immunodeficiency virus infection

Cited by 4 publications

References 24 publications

Que reste t-il de la microscopie électronique pour le diagnostic anatomopathologique en 2010 ?

Que reste t-il de la microscopie électronique pour le diagnostic anatomopathologique en 2010 ?

Aspects histopathologiques de l'infection par le VIH

Tubuloreticular Structures in Rectal Biopsies of SIV-infected Rhesus Monkeys (Macaca mulatta)

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