Ultrathin Cell‐Membrane‐Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for In Vivo Electrochemical Detection

Liu, Xiaomeng; Xiao, Tongfang; Wu, Fei; Shen, Mo-Yuan; Zhang, Meining; Yu, Hsiao‐hua; Mao, Lanqun

doi:10.1002/ange.201705900

Cited by 48 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[42] The concentration distribution of dopamine is summarized in Ta ble S2 in the Supporting Information. Moreover,conventional electrochemical methods have been intensively explored for in vivo DA detectioni nt he complex brain environment, [43][44][45][46][47] and they have typically limits of detection no better than nanomo- lar.W ec ompared the sensitivity with these reports (Ta ble S3 in the SupportingI nformation), and found the sensitivity of CN-Ts CuPc PEC system (LOD:2n m)w as uncompromisingly competitive( only al imited number of previousr eports have a better LOD) with additional specific merits, such as high selectivity over other,l ess explored, biologically relevant amines (e.g.,5 -HT). In this regard, the CN-TsCuPc PEC sensing system with an LOD of 2nm would be potentially applicable for in vivo DA detection.…”

Section: Resultsmentioning

confidence: 99%

Exfoliation and Sensitization of 2D Carbon Nitride for Photoelectrochemical Biosensing under Red Light

Zhao

Shen

et al. 2019

Chemistry A European J

View full text Add to dashboard Cite

Two-dimensional carbon nitride (CN) has drawn increasinga ttention as ac onjugated metal-free polymer for photoelectrochemical (PEC) biosensing. However,C No nly absorbsu ltraviolet andv ery limited visible light (l < 460 nm), whichp oses potentialr isks for biomolecules and also cannot pass through tissue for in vivo detection. Herein, simultaneousexfoliation and functionalization of CN nanosheets (CNNS) with copper phthalocyanine (TsCuPc) simply by mechanical milling, thanks to the delicate p-p interaction between them,i sr eported. Moreover,d ue to energy-level matching, an effective donor-acceptor (D-A) interaction with much-improved photocurrent underi rradiation with red light (l > 630 nm) was observed for the as-prepared CNNS-Ts CuPc. As an example, dopamine in blood was detected by using red light by aC NNS-TsCuPc photoelectrode with uncompromised linear range and detection limit, as well high selectivity.A so ne of the few successful demonstrations of red-light-responsive PEC sensing systems, this work takes a first step toward future in vivo applicationsb ye nriching the optoelectronic properties of CN with task-specific antenna molecules via D-A interaction.Supporting information and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

show abstract

Section: Resultsmentioning

confidence: 99%

Exfoliation and Sensitization of 2D Carbon Nitride for Photoelectrochemical Biosensing under Red Light

Zhao

Shen

et al. 2019

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…Chemical approaches use highly hydrophilic systems to create a hydration layer that is resistant to nonspecific protein adsorption and reduces inflammatory responses. For example, hydrophilic leukocyte membranes and conducting polymers tailored with zwitterionic phosphorylcholine have been demonstrated to prevent biofouling in CFM in vivo [ 160 , 161 ]. Physical approaches rely on the engineering of filtration membranes or porous electrodes that exhibit size-related diffusion restrictions.…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

Recent Advances in In Vivo Neurochemical Monitoring

Tan

Robbins

et al. 2021

Micromachines

View full text Add to dashboard Cite

The brain is a complex network that accounts for only 5% of human mass but consumes 20% of our energy. Uncovering the mysteries of the brain’s functions in motion, memory, learning, behavior, and mental health remains a hot but challenging topic. Neurochemicals in the brain, such as neurotransmitters, neuromodulators, gliotransmitters, hormones, and metabolism substrates and products, play vital roles in mediating and modulating normal brain function, and their abnormal release or imbalanced concentrations can cause various diseases, such as epilepsy, Alzheimer’s disease, and Parkinson’s disease. A wide range of techniques have been used to probe the concentrations of neurochemicals under normal, stimulated, diseased, and drug-induced conditions in order to understand the neurochemistry of drug mechanisms and develop diagnostic tools or therapies. Recent advancements in detection methods, device fabrication, and new materials have resulted in the development of neurochemical sensors with improved performance. However, direct in vivo measurements require a robust sensor that is highly sensitive and selective with minimal fouling and reduced inflammatory foreign body responses. Here, we review recent advances in neurochemical sensor development for in vivo studies, with a focus on electrochemical and optical probes. Other alternative methods are also compared. We discuss in detail the in vivo challenges for these methods and provide an outlook for future directions.

show abstract

“…The intrinsic basis of abundant life activities is enormous chemical reactions, thus accurately assaying the vital molecules involved in these fundamental reactions in living body is an indispensable means to reveal the physiological mechanisms in molecular level . Currently, in vivo electrochemical detection is a powerful and unparalleled approach to achieve this goal with high sensitivity, good selectivity, simplicity, rapidness, and low cost . However, external bias is always inevitable to induce the oxidation/reduction reactions of biomolecules on the electrode surface, which results in undesirable electrophysiological stimulation and thus brings out non‐negligibly abnormal secretion of biomolecules from living cells.…”

Section: Background and Originality Contentmentioning

confidence: 99%

Rationally Design of Near Infrared Light Responsive Micro‐Photoelectrodes for In Vivo Sensing of Neurotransmitter Molecules in Mouse Brain^†

Yue

et al. 2020

Chin. J. Chem.

View full text Add to dashboard Cite

Summary of main observation and conclusion The accurate quantification of neurotransmitter molecules is an indispensable means to reveal the physiological mechanisms of neuro movement in molecular level. However, existing detection strategies cannot fully meet practical needs, and the on‐site and in vivo detection of neurotransmitters in brain remains a great challenge. Here, we report the development of a near infrared light responsive photoelectrochemical (PEC) detection method for in vivo quantification of neurotransmitter dopamine in mouse brain. Under guidance of density function theory calculations, a combination strategy of non‐metal cation doping and defect engineering is introduced to rationally design the micro‐photoelectrodes with excellent biocompatibility and stability and implements the in vivo PEC detection of dopamine in mouse brain. It opens up a new way for the accurate in vivo detection of biomolecules and allows researchers to make novel inquiries for long‐standing questions in a new way.

show abstract

Ultrathin Cell‐Membrane‐Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for In Vivo Electrochemical Detection

Cited by 48 publications

References 33 publications

Exfoliation and Sensitization of 2D Carbon Nitride for Photoelectrochemical Biosensing under Red Light

Exfoliation and Sensitization of 2D Carbon Nitride for Photoelectrochemical Biosensing under Red Light

Recent Advances in In Vivo Neurochemical Monitoring

Rationally Design of Near Infrared Light Responsive Micro‐Photoelectrodes for In Vivo Sensing of Neurotransmitter Molecules in Mouse Brain^†

Contact Info

Product

Resources

About

Ultrathin Cell‐Membrane‐Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for In Vivo Electrochemical Detection

Cited by 48 publications

References 33 publications

Exfoliation and Sensitization of 2D Carbon Nitride for Photoelectrochemical Biosensing under Red Light

Exfoliation and Sensitization of 2D Carbon Nitride for Photoelectrochemical Biosensing under Red Light

Recent Advances in In Vivo Neurochemical Monitoring

Rationally Design of Near Infrared Light Responsive Micro‐Photoelectrodes for In Vivo Sensing of Neurotransmitter Molecules in Mouse Brain†

Contact Info

Product

Resources

About

Rationally Design of Near Infrared Light Responsive Micro‐Photoelectrodes for In Vivo Sensing of Neurotransmitter Molecules in Mouse Brain^†