Ultrathin-film oscillator biosensors excited by ultrafast light pulses

Ogi, Hirotsugu; Kawamoto, Tetsuya; Nakamura, Nobutomo; Hirao, Masahiko; Nishiyama, Masayoshi

doi:10.1016/j.bios.2010.06.074

Cited by 6 publications

(7 citation statements)

References 23 publications

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“…As demonstrated in our previous studies, 24,25) the picosecond ultrasonic system is highly applicable as an ultrahigh-sensitive oscillator biosensor, because the mass sensitivity of an oscillator biosensor is markedly enhanced as oscillator thickness decreases. 31,32) Considering that the oscillator used in a conventional oscillator biosensor is thicker than 10 µm quartz plates and the picosecond ultrasonic system can vibrate 10-100 nm oscillators, the sensitivity for adsorbed mass on the oscillator is drastically enhanced.…”

Section: Biosensor Applicationmentioning

confidence: 69%

“…Such a clear frequency change was not observed with the Ti/S-laser optics for a Pt film biosensor because of unstable acoustic responses. 24,25) The amount of frequency change due to the adsorption of the antigen reaches 1.7%, which is much larger than that detected with previous oscillator biosensors using quartz resonators by a factor of 10 4 . (The frequency change was about 0.0007% for detecting a 100 ng/ml hIgG even with a highly sensitive quartz-crystal-microbalance biosensor.…”

Section: Biosensor Applicationmentioning

confidence: 69%

“…Second, the intensity of the Ti/S pulse laser is unstable. One of the important applications of picosecond ultrasonics is ultrahighfrequency oscillator biosensor, 24,25) where acoustic responses at resonance of an ultrathin film are monitored during the binding reaction between biomolecules. Because the binding reaction takes a long time (∼30 min), a stable baseline is needed.…”

Section: Introductionmentioning

confidence: 99%

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Picosecond Ultrasound Spectroscopy with a Stable Fiber Laser for Ultrahigh-Frequency-Oscillator Applications: from Nanomechanics to Biosensors

Ogi

Kawamoto

Nakamichi

et al. 2012

Jpn. J. Appl. Phys.

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We developed a stable picosecond-ultrasound-spectroscopy system with a fiber-laser light source. A linearly polarized light pulse with 532 nm wavelength is split into pump and probe light pulses using a polarized beam splitter (PBS). The ultrahigh-frequency acoustic waves excited by the pump light pulse are successfully detected using the delayed probe light pulse with a signal-to-noise ratio higher than that of the traditional titanium-sapphire pulse laser. The wavelength used allows deep inspection of silicon because of less light absorption. The developed system is also applied to a biosensor with an ultrathin Pt film resonator, which shows significantly improved stability at 100 GHz. The amount of frequency change caused by the adsorption of target molecules is of the order of 10 −2 , which is much higher than that detected with conventional oscillator biosensors by a factor of 10 4 .

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Section: Biosensor Applicationmentioning

confidence: 69%

Section: Biosensor Applicationmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

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Picosecond Ultrasound Spectroscopy with a Stable Fiber Laser for Ultrahigh-Frequency-Oscillator Applications: from Nanomechanics to Biosensors

Ogi

Kawamoto

Nakamichi

et al. 2012

Jpn. J. Appl. Phys.

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“…Because the mass sensitivity is inversely proportional to the square of the thickness of the resonator, 13 a thin-film resonator is expected to improve the sensitivity. 14,15 A free-standing thin-film resonator is therefore promising to achieve an ultra-sensitive biosensor relying on its high quality factor.…”

mentioning

confidence: 99%

Suppression of Brillouin oscillation in transparent free-standing diamond thin films in picosecond ultrasound

Weng,

Nagakubo,

Watanabe

et al. 2022

Preprint

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“…Therefore, we developed a locally free-standing film resonator. 16) However, to keep the sensor surface flat, the film thickness has to exceed 100 nm, limiting its fundamental resonance frequency. Thus, a methodology for selectively exciting higher resonant modes is desired.…”

mentioning

confidence: 99%

Enhancement of ultrahigh-frequency vibration of an Au/Si₃N₄ composite resonator with picosecond ultrasound

Ogi¹,

Hirao²

2014

Appl. Phys. Express

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We found that the second through-thickness vibration mode of a gold/silicon-nitride composite thin film is selectively excited by picosecond ultrasound with high efficiency by controlling their thickness ratio. Its mechanical vibration frequency exceeds 50 GHz, being promising for ultrahigh-sensitive mass detector. We developed a theoretical model based on the strain-energy ratio between gold and silicon-nitride layers, and successfully explained the enhancement of the second vibration mode. The sensor chip was applied to detect immobilized proteins through the change in resonance frequency.An ultrafast light pulse excites subterahertz-frequency acoustic waves in nanoscale materials through impulsive thermal expansion, and they are detected by another ultrafast light pulse through modification of surface dielectric constant (photoelastic effect). This optical pumpprobe technique is called picosecond ultrasonic (PSU) method, which was first established by Thomsen and coworkers. 1) Several researchers evolve this method for studying behaviors of ultrahigh-frequency phonons in nanoscale materials. Their achievements include highfrequency surface-wave imaging, 2) evaluation of ultrahigh-frequency acoustic damping, 3,4) thermal excitation of shear waves, 5) discovery of anomalous elasticity of nanomaterials. [6][7][8] Recently, PSU method is intensively studied for ultrahigh-frequency oscillators: A resonator can be a mass-sensitive sensor because its resonance frequencies are changed by the mass-loading effect, and the mass sensitivity becomes significantly higher as the resonator mass decreases, corresponding to higher-frequency resonator. Because the PSU method allows excitation of ultrahigh-frequency vibrations of nanoscale materials, it is promising for ultrahigh-sensitive sensors. Surface acoustic wave resonances were detected by fabricating nanowires [9][10][11] and nanodots 12) on substrates, achieving ∼10 GHz resonators. Ultrafast vibrations (∼10 GHz) of GaAs nanopillars 13) and Au nanorings 14) were also successfully realized.In these methods, however, there is a frequency limitation caused by the lithography fineness. Furthermore, they require multistep fabrication procedures costly. The simplest resonator is a flat thin film, whose resonant frequencies can be easily increased by thinning the deposited film.The thin-film resonator were actually utilized for biosensors for detecting target proteins. 15) The disadvantage of the deposited thin-film resonator is significant vibrational-energy leakage 1/??

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Ultrathin-film oscillator biosensors excited by ultrafast light pulses

Cited by 6 publications

References 23 publications

Picosecond Ultrasound Spectroscopy with a Stable Fiber Laser for Ultrahigh-Frequency-Oscillator Applications: from Nanomechanics to Biosensors

Picosecond Ultrasound Spectroscopy with a Stable Fiber Laser for Ultrahigh-Frequency-Oscillator Applications: from Nanomechanics to Biosensors

Suppression of Brillouin oscillation in transparent free-standing diamond thin films in picosecond ultrasound

Enhancement of ultrahigh-frequency vibration of an Au/Si₃N₄ composite resonator with picosecond ultrasound

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Ultrathin-film oscillator biosensors excited by ultrafast light pulses

Cited by 6 publications

References 23 publications

Picosecond Ultrasound Spectroscopy with a Stable Fiber Laser for Ultrahigh-Frequency-Oscillator Applications: from Nanomechanics to Biosensors

Picosecond Ultrasound Spectroscopy with a Stable Fiber Laser for Ultrahigh-Frequency-Oscillator Applications: from Nanomechanics to Biosensors

Suppression of Brillouin oscillation in transparent free-standing diamond thin films in picosecond ultrasound

Enhancement of ultrahigh-frequency vibration of an Au/Si3N4 composite resonator with picosecond ultrasound

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Enhancement of ultrahigh-frequency vibration of an Au/Si₃N₄ composite resonator with picosecond ultrasound