Ultraviolet AI exposure of human skin results in Langerhans cell depletion and reduction of epidermal antigen-presenting cell function: partial protection by a broad-spectrum sunscreen

Dumay, Olivier; Karam, Amer; Vian, Laurence; Moyal, Dominique; Hourseau, C.; Stoebner, P; Peyron, J; Meynadier, J; Cano, Jean Paul; Meunier, Laurent

doi:10.1046/j.1365-2133.2001.04225.x

Cited by 90 publications

(72 citation statements)

References 38 publications

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“…SC, since it is the outer part of the epidermis [17][18][19], is identified as the main target of oxidative damage [20]. SC ·-tocopherol is decreased by UV exposure [9,14,21] and it is found to be effective against UV-induced immunosuppression [22], tumorigenesis [22], lipid peroxidation [23][24][25], chronic skin damage and tumors, erythema, 'sunburn cell' formation [26], epidermal Langerhans cell depletion [27,28], oxidative DNA damage, genotoxicity and reactive intermediates [29,30]. Vitamin E is probably the most widely investigated photoprotective substance besides sunscreens both of which are almost always present in skin care products.…”

Section: Environmental Stressors and Antioxidant Skin Networkmentioning

confidence: 99%

Antioxidants and the Response of Skin to Oxidative Stress: Vitamin E as a Key Indicator

Packer

Valacchi

2002

Skin Pharmacol Physiol

114

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As the outermost barrier of the body, the skin is directly and frequently exposed to a prooxidative environment, including solar UVA and UVB radiation, and air pollution. The skin is equipped with an elaborate system of antioxidant substances and enzymes that includes a network of redox active antioxidants. Among these, vitamin E has been identified as the predominant antioxidant both in murine and human skin and shows a characteristic gradient with lower levels towards the outer stratum corneum layers. Skin exposure to UV and ozon alone and in combination resulted in a significant potentiation of the UV-induced vitamin E depletion. Oxidants and antioxidants play an important role in maintaining a balance between free radicals produced by metabolism or derived from environmental sources. Cellular antioxidants may change their redox state, be targeted for destruction, regulate oxidative process involved in signal transduction, affect gene expression and pathways of cell proliferation and death. Here we provide an overview of the antioxidant system with a special relevance to skin.

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Section: Environmental Stressors and Antioxidant Skin Networkmentioning

confidence: 99%

Antioxidants and the Response of Skin to Oxidative Stress: Vitamin E as a Key Indicator

Packer

Valacchi

2002

Skin Pharmacol Physiol

114

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“…It was proved by Dumay et al that UVA1 (340-400 nm) with a dose of 60 J/cm 2 resulted in a lower HLA-DR expression [8]. After exposure of LCs in mice to UVB with a dose 200 J/m 2 , Denfeld et al observed an altered expression of costimulatory molecules CD80 (B7.1) and CD86 (B7.2) (ligands for CD28 in the interaction between LCs and T cells) [24].…”

Section: Effects Of Uv On Morphology and Phenotype Of Lcsmentioning

confidence: 99%

“…Similarly, single doses of UVA1 caused also a decrease in the number of LCs in human epidermis [7,8].…”

Section: Effects Of Uv Radiation On the Number Of Lcs In The Epidermismentioning

confidence: 99%

“…The formation of cyclobutane pyrimidine dimers and 6-4 photoproducts are main UV-dependent DNA modifications [23]. Cyclobutane thymidine dimers were found in about 27% of LCs migrating from the epidermis 18 hours after exposure to UVB (in examination of fluid obtained by blister suction) [8]. It was suggested that the significant damage to mitochondria and formation of numerous reactive oxygen species may lead to apoptosis of cells [7].…”

Section: Effects Of Uv On Morphology and Phenotype Of Lcsmentioning

confidence: 99%

“…Numerous studies showed a decrease in the number of LCs in the epidermis caused by exposure to UV radiation, including sunlight [5], solar simulated radiation (SSR) [6], UVA [7,8] and UVB [9,10]. Two mechanisms are considered responsible for this effect: mobilization and migration of LCs to the lymph nodes or induction of necrosis or apoptosis processes by UV [9][10][11][12].…”

Section: Effects Of Uv Radiation On the Number Of Lcs In The Epidermismentioning

confidence: 99%

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Effects of ultraviolet radiation on Langerhans cells

Chomiczewska-Skóra¹,

Adamus²,

Trznadel-Grodzka³

et al. 2013

cejoi

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Research on penetration of ultraviolet (UV) radiation into human skin shows that about 20% of UVA and 10% of UVB can reach the basal layer of the epidermis. As a consequence, Langerhans cells (LCs), located in suprabasal layers, are subject to the influence of the two types of UV radiation. This phenomenon leads to quantitative and qualitative alterations in LCs, including reduction in their number in the epidermis and modifications in morphology and immune functions. Studies show that two mechanisms may be responsible for their depletion from epidermis, namely, migration to the lymph nodes or induction of cell necrosis or apoptosis. UV radiation also affects the phenotype of LCs and their functions as antigen presenting cells. In recent years, the role of LCs in the UV-dependent immunosuppression and immune tolerance has been emphasized. The aim of the study is to review the literature about the influence of ultraviolet radiation on Langerhans cells.

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