Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color

Armas, Laura A.G.; Dowell, S. T.; Akhter, Mohammed P.; Duthuluru, Sowjanya; Huerter, Christopher J.; Hollis, Bruce W.; Lund, Richard; Heaney, Robert P.

doi:10.1016/j.jaad.2007.03.004

Cited by 243 publications

(201 citation statements)

References 19 publications

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“…They also experience higher incidence and/or mortality rates for several malignancies, including breast, colorectal, and prostate (112). Although it is known that the lower circulating 25(OH)D level in black populations results from the greater melanin pigmentation in darker skin reducing solar ultraviolet B radiation-related cutaneous vitamin D synthesis (113), the reasons for the racial disparities in cancer incidence and mortality have yet to be elucidated (112). Vitamin D has therefore been proposed to explain some of the racial disparities in cancer risk (114)(115)(116) and mortality (117)(118)(119).…”

Section: Vitamin D and Cancer In Black Populationsmentioning

confidence: 99%

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges

Mondul

Weinstein

Layne

et al. 2017

Epidemiologic Reviews

167

133

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There has been substantial enthusiasm recently regarding the potential role of vitamin D in the primary and secondary prevention of cancer. Laboratory studies demonstrate a range of anticarcinogenic effects for vitamin D compounds, but human studies have yielded little consistent evidence supporting a protective association. Higher circulating levels of vitamin D (i.e., 25-hydroxyvitamin D or 25(OH)D) appear to be associated with reduced risk of colorectal and bladder malignancies, but higher risk of prostate and possibly pancreatic cancers, with no clear association for most other organ sites examined. Despite there being no official institutional recommendations regarding the use of vitamin D supplements for cancer prevention, screenings for vitamin D deficiency and vitamin D supplement use have increased substantially over the past decade. These widespread practices demonstrate that population sociobehavioral changes are often adopted before scientifically well-informed policies and recommendations are available. This review critically examines the currently available epidemiologic literature regarding the associations between circulating 25(OH)D, vitamin D supplementation, and vitamin D-related genetic variation and cancer risk and mortality, with a particular emphasis on prospective studies. We identify several important gaps in our scientific knowledge that should be addressed in order to provide sufficient reproducible data to inform evidence-based recommendations related to optimal 25(OH)D concentrations (and any role for vitamin D supplementation) for the primary and secondary prevention of cancer. With few exceptions, such recommendations cannot be made at this time.

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Section: Vitamin D and Cancer In Black Populationsmentioning

confidence: 99%

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges

Mondul

Weinstein

Layne

et al. 2017

Epidemiologic Reviews

167

133

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“…The privilege instead must be given to the intake that prevailed during the evolution of human physiology, the intake to which, presumably, that physiology is fine-tuned. So far as can be judged from numerous studies documenting the magnitude of the effect of sun exposure, (12,13) the primitive intake would have been at least 4000 IU/day and probably two to three times that level, with corresponding serum 25(OH)D levels ranging from 40 to 80 ng/mL. The fact that primitive levels would have been higher than current IOM recommendations does not, of course, prove their necessity today.…”

Section: Introductionmentioning

confidence: 97%

Why the IOM recommendations for vitamin D are deficient

Heaney¹,

Holick²

2011

Journal of Bone and Mineral Research

333

237

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“…UVB phototherapy has been shown to increase serum 25(OH) D concentrations in several studies. 1,2 In the last decade, ultraviolet A1 (UVA1, 340-400nm) phototherapy has emerged as a therapeutic modality in sclerosing and inflammatory skin conditions, and vitamin D has been identified as important mediator in inflammatory skin disease. 3 No data is available on vitamin D level variations under UVA1 phototherapy.…”

Section: Introductionmentioning

confidence: 99%

Phototherapy with UVB narrowband, UVA/UVBnb, and UVA1 differentially impacts serum 25-hydroxyvitamin-D3

Feldmeyer

Shojaati

Spanaus³

et al. 2013

Journal of the American Academy of Dermatology

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BACKGROUND: Ultraviolet (UV) B radiation increases serum 25-hydroxyvitamin-D3 [25(OH)D], but the influence of UVA1 and UVA/narrowband UVB (UVBnb) phototherapy on serum vitamin D is unknown. OBJECTIVE: We sought to investigate the influence of UVBnb, UVA1, and UVA/UVBnb phototherapy on serum levels of 25(OH)D and related parameters in patients with an inflammatory skin condition. METHODS: 25(OH)D, as well as calcium, parathormone, phosphate, and albumin were measured before therapy, 2 weeks after start, and after completion of the phototherapy. Diagnoses were divided in 4 groups: atopic dermatitis, psoriasis, morphea, and others. RESULTS: We surveyed 116 dermatologic patients undergoing phototherapy with UVA1 (n = 38), UVA/UVBnb (n = 30), or UVBnb (n = 48) 2 to 3 times a week for 53 to 90 days. UVBnb phototherapy increased serum 25(OH)D from 22.1 to 39.5 ng/mL after the therapy (P < .001). The lower the baseline 25(OH)D level was, the steeper the increase in 25(OH)D was upon application of UVBnb phototherapy. UVA/UVBnb therapy also increased serum 25(OH)D, from 23.9 to 50.3 ng/mL (P = .003). Conversely, in the UVA1 therapy group, 25(OH)D serum levels decreased significantly from 21.9 to 19.0 ng/mL (P < .001). LIMITATIONS: The study design was open trial without randomization. An influence of a precise skin disease cannot be excluded because of the heterogeneous diagnoses. Bias may have arisen from patient preference for treatment at our center, referral, unrecognized differences in underlying skin disease, and other factors.

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Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color

Cited by 243 publications

References 19 publications

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges

Why the IOM recommendations for vitamin D are deficient

Phototherapy with UVB narrowband, UVA/UVBnb, and UVA1 differentially impacts serum 25-hydroxyvitamin-D3

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