Umbilical Cord Blood Histamine Levels in Newborn Infants with and without Perinatal Anoxia

Porter, J. F.; Young, J; Rasheed, Saad Tawfik

doi:10.1159/000240234

Cited by 2 publications

(1 citation statement)

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“…Available evidences suggested that changes of histamine concentration in maternal plasma were involved in a number of complications from human pregnancy, for instance preeclampsia and preterm labor [ 14 , 30 , 31 ]. This study found that histamine concentration was increased in umbilical plasma from frozen ET when comparing with the normal pregnancy, which might influence vascular constriction or dilation in umbilical vascular systems.…”

Section: Discussionmentioning

confidence: 99%

In vitro fertilization with frozen embryo transfer increased histamine-mediated contractile sensitivity via PKCβ in human umbilical vein

Tang

et al. 2023

Reprod Biol Endocrinol

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Objective In vitro fertilization-embryo transfer (IVF-ET) technologies (especially frozen ET) have been widely used, which might affect maternal and fetal health. Information regarding influence of IVF-ET on the vasoconstriction of human umbilical vein (HUV) is limited. This study determined effects of frozen ET on histamine-mediated vascular responses in HUV and related mechanisms. Methods and results HUVs were collected from frozen ET conceived pregnancy and spontaneously conceived pregnancy (control). Histamine concentration in umbilical plasma was higher in frozen ET group than the control. Histamine-mediated contractile response curve was left-shifted in the frozen ET group when comparing with the control. In isolated HUV rings, H1R showed a critical role in regulating vascular constriction, while H2R played little roles in regulating vessel tone. Iberiotoxin and 4-aminopyridine didn’t significantly change histamine-mediated constriction in HUVs. Histamine-induced vasoconstrictions were significantly decreased by nifedipine, KN93, or GF109203X, while the inhibitory effects were significantly greater in the frozen ET group in comparison to the control. The constrictions by Bay K8644, phenylephrine, or PDBu were stronger in frozen ET, respectively. There was a decrease in the protein expressions of H1R and H2R, an increase in protein expressions of BKCaα and PKCβ. Conclusions Histamine-induced constriction in HUV was mainly via H1R. The increased sensitivity to histamine in HUV following frozen ET cycles were linked to the enhanced PKCβ protein expression and function. The new data and findings in this study provide important insight into influences of frozen ET on fetal vessel development and potential influence in long-term.

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Section: Discussionmentioning

confidence: 99%