Effects of vasoactive agents on isolated human umbilical arteries and veins

Altura, Burton M.; Malaviya, D.; Reich, Charles F.; Orkin, Louis R.

doi:10.1152/ajplegacy.1972.222.2.345

Cited by 196 publications

(144 citation statements)

References 25 publications

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“…Maximal or submaximal contractions were also seen on occasion in response to washing the preparations. As described previously (Altura et al, 1972), maximal activator-induced responses were often less during the first few hours of an experiment than those seen during subsequent stimulations.…”

Section: Drugssupporting

confidence: 55%

“…1.5mm x 20mm for arteries and 2.5mm x 25mm for veins, similar to that described previously (Altura et al, 1972). They were each suspended in a Harvard Universal Jacketed Isolated Organ Bath and kept at 37°C by a Harvard Thermocirculator.…”

Section: Methodsmentioning

confidence: 99%

“…They were initially allowed 2-3 h to equilibrate in the bath under a resting tension of 2g and were frequently washed with Krebs-Ringer bicarbonate solution (Altura et al, 1972). The tissues were then tested with potassium chloride (KCI), a known contractile activator (Altura et al, 1972), to confirm the integrity of the preparation and periodically throughout the experiment, as a control, to estimate vessel sensitivity and consistency. This was done by adding KCl to the bath medium and measuring the contractile force developed.…”

Section: Methodsmentioning

confidence: 99%

“…Sympathomimetic amines were shown to induce responses in isolated umbilical arterial and venous strips (Somlyo et al, 1965). Using umbilical vessels from human cords, varying contractile responses to 10 different vasoactive agents were demonstrated (Altura et al, 1972).…”

mentioning

confidence: 99%

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Vasoactive actions of local anaesthetics on human isolated umbilical veins and arteries

Monuszko

Halevy

Freese

et al. 1989

British J Pharmacology

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1 An in vitro study, using helical preparations of human umbilical arteries and veins obtained from healthy women at term pregnancy, was designed to determine: (a) whether three local anaesthetics commonly utilized in obstetric anaesthesia (bupivacaine, 2-chloroprocaine, and lignocaine) can induce contraction or relaxation of resting umbilical vessels; (b) whether these agents can induce contraction or relaxation of umbilical vessels which have been previously induced to contract by a known activator, potassium chloride (KCI); and (c) the relative potency of these agents as compared to KC1. 2 The results indicate that: (a) these local anaesthetics are vasoactive on human umbilical vascular smooth muscle; (b) bupivacaine induces contraction in over 90% of the resting vessels examined, while 2-chloroprocaine consistently causes relaxation and lignocaine causes a small degree of contraction in 40% of vessels examined; (c) bupivacaine causes further contraction (or potentiation) of KC1-contracted muscle in 50% of the vessels studied, while 2-chloroprocaine and lignocaine both induce relaxation of these contracted vessels.Introducion

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Section: Drugssupporting

confidence: 55%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Vasoactive actions of local anaesthetics on human isolated umbilical veins and arteries

Monuszko

Halevy

Freese

et al. 1989

British J Pharmacology

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“…It has long been known that serotonin and other compounds that bind serotonin receptors (such as histamine) an alter tone in the umbilical artery and vein [11]. The human umbilical artery and vein have both have been reported to express 5HT1D beta, 5-HT2A, 5-HT2B, 5-HT4 and 5-HT7 [12,13].…”

mentioning

confidence: 99%