Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema

Shaheen, Salma; Newson, R B; Henderson, John; Emmett, Pauline M; Sherriff, Andrea; Cooke, M

doi:10.1183/09031936.04.00117803

Cited by 152 publications

(128 citation statements)

References 41 publications

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“…Rather, we observed a potential unadjusted protective effect of maternal intake of dietary folate on the risk of eczema. In addition, we did not confirm the associations that have been reported between vitamin C (Litonjua et al, 2006), calcium (Miyake et al, 2010b) and iron (Shahen et al, 2004) and the risk of eczema. So far, no study has investigated the effect of maternal intake of antioxidants on the risk of rhinitis in the offspring.…”

Section: Discussioncontrasting

confidence: 55%

“…Some studies have reported a reduced risk of asthma and wheezing in the offspring with high maternal intake of vitamin E during pregnancy (Martindale et al, 2005;Devereux et al, 2006;Litonjua et al, 2006;Miyake et al, 2010a), whereas no association was observed regarding eczema (Devereux et al, 2006;Litonjua et al, 2006;Miyake et al, 2010b). Similar inconsistencies have been seen concerning maternal intake of zinc and the risk of allergic outcomes (Shahen et al, 2004;Martindale et al, 2005;Devereux et al, 2006;Litonjua et al, 2006;Miyake et al, 2010b). Umbilical cord selenium and iron has been associated with wheezing and eczema in children (Shahen et al, 2004).…”

Section: Introductionmentioning

confidence: 74%

“…Similar inconsistencies have been seen concerning maternal intake of zinc and the risk of allergic outcomes (Shahen et al, 2004;Martindale et al, 2005;Devereux et al, 2006;Litonjua et al, 2006;Miyake et al, 2010b). Umbilical cord selenium and iron has been associated with wheezing and eczema in children (Shahen et al, 2004). Maternal supplementation of folic acid during pregnancy was reported recently to be associated with increased risk of asthma (Whitrow et al, 2009) and wheezing (Håberg et al, 2009), whereas high intake of calcium and b-carotene reduced the risk of allergies in the offspring (Miyake et al, 2010a, b).…”

Section: Introductionmentioning

confidence: 87%

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Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

et al. 2011

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Background/Objectives: The potential immune functions related to the damages induced by oxygen-free radicals suggest that antioxidants may have a role in the development of allergies. The objective was to investigate the association between maternal intake of antioxidants during pregnancy and the risk of asthma, rhinitis and eczema in 5-year-old children. Subjects/Methods: This study was on the basis of the Finnish Type 1 Diabetes Prediction and Prevention Nutrition Study, a population-based birth cohort study with 5-year follow-up. Complete information on maternal food frequency questionnaire data and ISAAC (International Study of Asthma and Allergies in Childhood)-based allergic outcomes were available for 2441 children. Cox proportional regression and logistic regression were used for the analyses. Results: Maternal intake of any of the antioxidants was not significantly associated with the risk of asthma, rhinitis or eczema in the offspring, except for dietary intake of magnesium, which was independently associated with protection against eczema (OR 0.78; 95% CI 0.62-0.97). Conclusion: Maternal intake of dietary magnesium during pregnancy may protect against the risk of eczema in the offspring. We did not confirm previous observations concerning other antioxidants. This may be due to the variable amount of antioxidant intake across studies and also indicative of the hypothesis that there may be a critical time window in pregnancy during which antioxidants might modify the risk of allergies in the offspring.

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Section: Discussioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 87%

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Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

et al. 2011

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“…In animal models, vitamin E, zinc and vitamin D have been shown to modify fetal lung development, and vitamin E, zinc, vitamin D and PUFA can modulate T-cell responses. In humans, birth cohort studies have reported associations between wheezing and eczema in early life and low prenatal status of selenium and iron (17) , low maternal intake of vitamin E (9,18,19) , vitamin D (20,21) , apple and fish (10,22,23) .…”

Section: Maternal Diet During Pregnancymentioning

confidence: 99%

Prenatal and childhood Mediterranean diet and the development of asthma and allergies in children

Chatzi

Kogevinas

2009

Public Health Nutr.

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Objective: To discuss current evidence about the relation between prenatal and childhood Mediterranean diet, and the development of asthma and allergies in children. Design: Review of the literature. Setting and results: Four recent studies conducted in Mediterranean countries (Spain, Greece) and one conducted in Mexico evaluated the association between childhood Mediterranean diet and asthma outcomes in children.

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“…Moreover, exposure to specific nutrients and factors via breast milk is critical for development 62 . With regards to this, many factors have been characterised to be crucial in development such as exposure to pollutants, intake of folic acid, vitamin D, antioxidants such as selenium [63][64][65] , and most importantly FA (ref. 66,67 ).…”

Section: Fatty Acids In Maternal and Offspring Healthmentioning

confidence: 99%

Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease - A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease

Kremmyda¹,

Tvrzická²,

Staňková³

et al. 2011

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

154

134

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Background. This is the second of two review parts aiming at describing the major physiological roles of fatty acids, as well as their applications in specific conditions related to human health.Results. The review included the current literature published in Pubmed up to March 2011. In humans, fatty acids are a principle energy substrate and structural components of cell membranes (phospholipids) and second messengers. Fatty acids are also ligands of nuclear receptors affecting gene expression. Longer-chain (LC) polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid are precursors of lipid mediators such as eicosanoids (prostaglandins, leukotrienes, thromboxanes), resolvins and neuroprotectins. Lipid mediators produced by EPA and DHA (LC n-3 PUFA; mainly found in oily fish) are considered as inflammation-resolving, and thus, fish oil has been characterised as antiinflammatory. Recommendations for EPA plus DHA intake from oily fish vary between 250-450 mg/day. Dietary reference values for fat vary between nutrition bodies, but mainly agree on a low total and saturated fat intake. The existing literature supports the protective effects of LC n-3 PUFA (as opposed to n-6 PUFA and saturated fat) in maternal and offspring health, cardiovascular health, insulin sensitivity, the metabolic syndrome, cancer, critically ill patients, and immune system disorders.Conclusion. Fatty acids are involved in multiple pathways and play a major role in health. Further investigation and a nutrigenomics approach to the effects of these biocompounds on health and disease development are imperative and highlight the importance of environmental modifications on disease outcome.humans. Thus, these FA may be characterised as conditionally essential depending on EFA availability. Genetic variation in human desaturase genes affects FA metabolism, plasma lipid profiles, and risk of disease development [5][6][7] . Recommendations for minimum dietary intake of EPA plus DHA vary between 250-450 mg/day 8 , especially for pregnant women and those of reproductive age. Rich sources of LC n-3 PUFA are fish oils and the flesh of oily fish, whereas non-oily (white) fish contain them but in lower amounts.Long-chain PUFA with 18-20 carbon atoms, including EPA and AA, are precursors of eicosanoids (prostaglandins, leucotrienes and thromboxanes), which have a broad scale of regulatory, autocrine and paracrine effects. Long-chain PUFA with 20 and 22 carbon atoms are precursors of autacoids -resolvins (resolution phase interaction products), lipoxins and neuroprotectins 9 . FA are also ligands of nuclear receptors which take part in the subcellular control of metabolic pathways. Covalent modification of proteins by FA acylation enables their incorporation into membranes. Hydroxy FA are activators of some nuclear factors and are responsible for the expression of proinflammatory cytokines (interleukin (IL)-1,

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Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema

Cited by 152 publications

References 41 publications

Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

Prenatal and childhood Mediterranean diet and the development of asthma and allergies in children

Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease - A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease

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