Umbilical Metastasis From Carcinoma of the Pancreas

Chatterjee, Satya N.; Bauer, H

doi:10.1001/archderm.1980.01640320104025

Cited by 25 publications

(11 citation statements)

References 5 publications

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“…They all showed multiple lesions and/or systemic involvement, and died within a period of 6 months. 5,7–9 Only Brownstein et al . reported a patient with a unique morphoea‐like lesion on the flank, whose histological examination revealed a metastatic origin, and the primary tumour was found in the pancreas 3 months later.…”

Section: Reportmentioning

confidence: 99%

Solitary cutaneous metastasis on the buttock: a disclosing sign of pancreatic adenocarcinoma

Flórez¹,

Rosón²,

Sánchez‐Aguilar³

et al. 2000

Clinical and Experimental Dermatology

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A 48-year-old man, previously healthy and asymptomatic, showed a unique skin lesion located on the right buttock. The histopathological study of the lesion disclosed an adenocarcinoma metastatic to the skin. The primary tumour was found at the head of the pancreas, and was confirmed by biopsy. Six months after the beginning of treatment with Gemcitabine the patient is still asymptomatic, and the cutaneous lesion has disappeared. Carcinomas of the pancreas represent less than 5% of human malignant neoplasms, skin involvement is rare, and metastasis generally multiple and situated in the periumbilical area. To our knowledge, very few patients have been reported with a solitary cutaneous lesion disclosing a pancreatic adenocarcinoma. The atypical location, the absence of related symptoms or analytical disorders, and the good progress of the patient make this case especially interesting.

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Section: Reportmentioning

confidence: 99%

Solitary cutaneous metastasis on the buttock: a disclosing sign of pancreatic adenocarcinoma

Flórez¹,

Rosón²,

Sánchez‐Aguilar³

et al. 2000

Clinical and Experimental Dermatology

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“…Several authors have advocated wide excision with extensive search for the primary lesion [30,31], radiotherapy [32], and surgery with adjuvant therapy [26]. Majmudar and colleagues [26] have shown that patients treated aggressively with both surgery and adjuvant therapy live for an average of 17.6 months, which is more than with surgery alone (7.4 months), adjuvant therapy alone (10.3 months), or no treatment (2.3 months).…”

Section: Discussionmentioning

confidence: 99%

Sister Mary Joseph's nodule at a University teaching hospital in northwestern Tanzania: a retrospective review of 34 cases

et al. 2013

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BackgroundSister Mary Joseph’s nodule is a metastatic tumor deposit in the umbilicus and often represents advanced intra-abdominal malignancy with dismal prognosis. There is a paucity of published data on this subject in our setting. This study was conducted to describe the clinicopathological presentation and treatment outcome of this condition in our environment and highlight challenges associated with the care of these patients, and to proffer solutions for improved outcome.MethodsThis was a retrospective study of histologically confirmed cases of Sister Mary Joseph’s nodule seen at Bugando Medical Centre between March 2003 and February 2013. Data collected were analyzed using descriptive statistics.ResultsA total of 34 patients were enrolled in the study. Males outnumbered females by a ratio of 1.4:1. The vast majority of patients (70.6%) presented with large umbilical nodule > 2 cm in size. The stomach (41.1%) was the most common location of the primary tumor. Adenocarcinoma (88.2%) was the most frequent histopathological type. Most of the primary tumors (52.9%) were poorly differentiated. As the disease was advanced and metastatic in all patients, only palliative therapy was offered. Out of 34 patients, 11 patients died in the hospital giving a mortality rate of 32.4%. Patients were followed up for 24 months. At the end of the follow-up period, 14(60.9%) patients were lost to follow-up and the remaining 9 (39.1%) patients died. Patients survived for a median period of 28 weeks (range, 2 to 64 weeks). The nodule recurred in 6 (26.1%) patients after complete excision.ConclusionSister Mary Joseph’s nodule of the umbilicus is not rare in our environment and often represents manifestation of a variety of advanced intra-abdominal malignancies. The majority of the patients present at a late stage and many with distant metastases. The patient's survival is very short leading to a poor outcome. Early detection of primary cancer at an early stage may improve the prognosis.

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“…13,20,29,32,53 Most cases involved metastasis of adenocarcinoma (278/ 368). [7][8][9][10][11][12][13]15,16,[18][19][20][21][22][23][24][25][26][27][28][29][30][32][33][34][35][36][37]41,42,[44][45][46][47][48][49][53][54][55][56][57][58][59][60][61][62][63][64] Fifteen cases of s...…”

Section: Histologyunclassified

“…In 152 cases (152/368), umbilical metastasis was discovered before the diagnosis of primary cancer; 7,8,35,39,41,42,44,46,47,[50][51][52][53][54][55][56][58][59][60][61][62][63] Sister Mary Joseph's nodule was the only initial presentation of internal malignancy in 97 of these 152 cases. 7,[11][12][13][14][15][16]18,19,[21][22][23][24][25][26][27][28][29][30][31][32][33]35,41,44,46,47,50,51,…”

Section: Prognosismentioning

confidence: 99%