Umbilical metastasis or Sister Mary Joseph's nodule

Dubreuil, Aurelie; Dompmartin, Anne; Barjot, Philippe; Louvet, Samuel; Leroy, D.

doi:10.1046/j.1365-4362.1998.00326.x

Cited by 157 publications

(180 citation statements)

References 41 publications

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“…Geralmente é secundária a tumores intra-abdominais, mas metástases de outros sítios como pulmão e mama também são relatadas na literatura. [1][2][3] Entre os tumores intra-abdominais são mais frequentes o gástri-co, no homem, e os ovarianos, na mulher. O câncer de pâncreas é o quinto sítio mais frequente, ficando atrás dos tumores de intestino e de origem desconhecida.…”

Section: Comentáriosunclassified

Caso para diagnóstico* (Metástase umbilical de carcinoma pancreático "Sister Mary Joseph Nodule")

Colla

Lovatto

Duquia

2009

An. Bras. Dermatol.

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Resumo: Paciente masculino de 56 anos foi hospitalizado com história de dor abdominal difusa. Ao exame da pele apresentava nódulo infiltrativo eritematovioláceo na região umbilical, cujo exame histológico revelou adenocarcinoma pouco diferenciado. A tomografia abdominal demonstrou neoplasia pancreática avançada com envolvimento hepático. Foi feito, então, o diagnóstico de adenocarcinoma pancreático com metástase umbilical -nódulo de Sister Mary Joseph. Palavras-chave: Metástase neoplásica; Pâncreas; Umbigo Abstract: Abstract: A 56-year-old man was hospitalized with a history of diffuse abdominal pain. Cutaneous examination revealed an erythematous to violaceous, infiltrative nodule of the umbilicus. Histologic examination demonstrated poorly differentiated adenocarcinoma. Abdominal tomography showed advanced pancreatic cancer with metastatic involvement of the liver and the diagnosis of pancreatic adenocarcinoma with umbilical metastasis -Sister Mary Joseph´s nodule.

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Section: Comentáriosunclassified

Caso para diagnóstico* (Metástase umbilical de carcinoma pancreático "Sister Mary Joseph Nodule")

Colla

Lovatto

Duquia

2009

An. Bras. Dermatol.

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“…The primary tumor most frequently is ovarian carcinoma in women and gastric cancer in men [28]. Despite the direct blood vessel connection, such type of metastasis is rare among skin metastases [27,28]. Furthermore, in our recent report on abdominal skin metastases of gastrointestinal cancers, we found no association with peritoneal involvement [18].…”

Section: Vascular Anatomy and Lymphovascular Disseminationmentioning

confidence: 49%

“…Accordingly, abdominal cancers at the stage of peritoneal dissemination may metastasize into the umbilicus also called Sister Mary Joseph's nodule [27]. The primary tumor most frequently is ovarian carcinoma in women and gastric cancer in men [28]. Despite the direct blood vessel connection, such type of metastasis is rare among skin metastases [27,28].…”

Section: Vascular Anatomy and Lymphovascular Disseminationmentioning

confidence: 99%

Tumor type-specific and skin region-selective metastasis of human cancers: another example of the “seed and soil” hypothesis

Kovács

Hegedűs

Kenessey

et al. 2013

Cancer Metastasis Rev

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Metastasis of human cancer is an organ-selective process that is determined by anatomical and biological factors as well as by specific microenvironmental properties. Dissemination of visceral malignancies to the skin is rather rare and usually occurs in a later stage of the disease. Using statistical approaches, both positive (renal and lung cancers) and negative (pancreatic and liver cancers) organ preferences can be identified in a variety of cancers. While certain cancer types are characterized by random distribution for skin metastasis (liver cancer), a number of cancers demonstrate a colonization preference to the region of origin: lung cancer to the supradiaphragmatic (mostly chest) and colorectal cancers to the infradiaphragmatic (abdominal) skin regions. In certain cases, however, skin metastasis develops more frequently at specific distant locations, as evidenced by the dissemination of renal cancer at the head and neck region. These findings are clinically relevant and useful especially in patients where skin metastasis is the first indication of a malignancy. Nevertheless, it is a strong argument for the predominant role of microenvironmental factors in cancer dissemination. On the other hand, skin metastases of visceral cancers provide a unique model to analyze the pathomechanisms determining organ selectivity, including the organ-specific vascularization, the dermatome-specific innervation, or immunological and developmental factors.

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“…It is an indication of poor prognostic outcome where palliation is the mainstay of patient management. Also, an estimated 1-3% of abdomino-pelvic malignancies arising from the stomach, pancreas, colon, prostate and liver manifest with umbilical metastasis (7,(10)(11)(12)(13). Other uncommon primary origins include the breast, lung, ovary and kidney.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous umbilical metastases in post-menopausal females with gynaecological malignancies

Samaila

Adesiyun

Waziri

et al. 2012

J Turkish German Gynecol Assoc

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Gynaecological malignancies frequently metastasize to contiguous structures, internal organs and bones. Cutaneous metastasis as a primary or recurrent presentation of these malignancies is rare and only a few cases have been reported in the literature. A twenty year (1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010) retrospective search for umbilical metastasis from gynaecological malignancies in our departmental case records showed only four cases. Four postmenopausal females presented with painful cutaneous umbilical (Sister Joseph's) nodules. The clinical examinations of all four patients revealed well delineated nodules of varying sizes and degrees of ulceration. Other findings were matted axillary and inguinal lymph node enlargement, intra-abdominal and pelvic masses, vaginal discharge and vaginal bleeding. Incisional tissue biopsies from the nodules were processed in paraffin wax and stained with haematoxylin and eosin. Histology of the sections showed pigmented skin overlying metastatic malignant tumours consistent with adenocarcinoma from the endometrium and ovary in three cases, and squamous cell carcinoma, large cell keratinizing from the cervix uteri in the fourth case. Gynaecological cancers have a global spread and varied geographic distribution. Cervical cancer is the commonest in our setting and patients often present to hospital with advanced stage disease. Ovarian and endometrial cancers are infrequent and their diagnosis may be delayed by non-specificity of presenting clinical symptoms from other benign tumours at these sites. Although umbilical metastasis is commonly associated with gastro-intestinal malignancies, its presence may be the first harbinger of occult gynaecologic cancer. (J Turkish-German Gynecol Assoc 2012; 13: 204-7)Key words: Metastasis, umbilical, cervix uteri, squamous cell carcinoma, endometrial adenocarcinoma Received: 04 November, 2011 Accepted: 03 January, 2012Jinekolojik maligniteler sıklıkla komşu yapılara, iç organlara ve kemiklere metastaz yaparlar. Bu malignitelerin primer veya rekürren prezentasyonu olarak deri metaztazları enderdir ve literatürde sadece bir kaç olgu bildirilmiştir. Jinekolojik malignitelerden kaynaklanan umbilikal metaztazlar için departmanımızın olgu kayıtlarında yirmi yıllık (1991-2010) retrospektif taramada sadece dört olgu bulundu. Menopoz sonrası dört kadın deriyi tutan ağrılı umbilikal nodüllerle (Rahibe Joseph) başvurmuştu. Dört hastanın klinik muayenesi farklı büyüklükte ve farklı ülserasyon derecelerinde iyi sınırlanmış nodülleri ortaya koymuştu. Diğer bulgular aksillar ve inguinal lenf nodlarında paket halinde büyüme, karın içi ve pelvik kitleler, vajinal akıntı ve vajinal kanama idi. Nodüllerden insizyonla elde edilen doku biyopsileri parafin mumunda işlenmiş ve hematoksilin-eozin ile boyanmıştı. Kesitlerin histolojisi üç olguda endometriyum ve overden köken alan adenokarsinoma ile uyumlu metastatik malign tümör ve üstünü örten pigmente deriyi, dördüncü olguda servik...

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Umbilical metastasis or Sister Mary Joseph's nodule

Cited by 157 publications

References 41 publications

Caso para diagnóstico* (Metástase umbilical de carcinoma pancreático "Sister Mary Joseph Nodule")

Caso para diagnóstico* (Metástase umbilical de carcinoma pancreático "Sister Mary Joseph Nodule")

Tumor type-specific and skin region-selective metastasis of human cancers: another example of the “seed and soil” hypothesis

Cutaneous umbilical metastases in post-menopausal females with gynaecological malignancies

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