Umbilical venous catheterization and the risk of portal vein thrombosis

Schwartz, Dana; Gettner, Patricia; Konstantino, Monica M.; Bartley, Christine L.; Keller, Marc S.; Ehrenkranz, Richard A.; Jacobs, Harris C.

doi:10.1016/s0022-3476(97)70109-4

Cited by 75 publications

(34 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, our data are in accord with very recently published adult series of cases with portal vascular occlusion demonstrating that prothrombotic disorders, especially defects within the protein C pathway, contributed to this rare thrombotic manifestation in the patients investigated (Denninger et al, 2000;Egesel et al, 2000). Thus, we suggest that this difference in the aetiology of childhood PVT with respect to genetic prothrombotic risk factors is mainly as a result of the system of patient recruitment, different childhood age populations, and the inclusion or exclusion of catheter-related thrombosis that, in two prospective studies, has been shown not to be commonly associated with a risk of PVT in sick neonates (Schwartz et al, 1997;Guimaraes et al, 1998). Hepatic venous vascular occlusion in neonates and infants is rare and was not found in the previously reported ESPED survey (Nowak-Go Èttl et al, 1997b).…”

Section: Risk Factorsmentioning

confidence: 81%

Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors – a multicentre case–control study

Heller

Schobeß²,

Kurnik³

et al. 2000

Br J Haematol

View full text Add to dashboard Cite

The factor V (FV) G1691A mutation, the prothrombin (PT) G20210A variant, the methylenetetrahydrofolate reductase (MTHFR) T677T genotype, together with fasting homocysteine (HCY) concentration, lipoprotein (Lp)(a), anti‐thrombin (AT), protein C (PC), protein S (PS) and anti‐cardiolipin antibodies were investigated in 65 consecutively recruited infants (neonate to < 12 months) with renal venous thrombosis (RVT; n = 31), portal vein thrombosis (PVT; n = 24) or hepatic vein thrombosis (HVT n = 10), and 100 age‐ and sex‐matched healthy controls. FV G1691A was found in 14 babies (heterozygous: RVT n = 9, PVT n = 4; homozygous HVT n = 1) and five controls, the MTHFR TT677 genotype together with increased HCY in four infants with thrombosis (RVT n = 2; PVT n = 1; HVT n = 1) compared with one control, and the PT G20210A variant was present in one control only. PC type I deficiency was diagnosed in three patients (RVT n = 2; PVT n = 1) and AT deficiency in two patients (RVT n = 1; PVT n = 1). Three neonates with spontaneous thrombosis showed FV G1691A combined with Lp(a) and the FV G1691A was combined with the PT G20210A genotype in two infants. Additional triggering factors were reported in 27 patients (41·5%). The overall odds ratios (ORs) and 95% confidence intervals (CIs) with respect to the different thrombosis locations were: RVT (OR/CI: 10·9/3·85–31·1; P < 0·0001), PVT (5·47/1·7–17·6; P < 0·0007) and HVT (3·3/0·58–18·7; P = 0·18). The data presented here suggest that genetic prothrombotic risk factors also play an important role in abdominal venous thrombosis during infancy.

show abstract

Section: Risk Factorsmentioning

confidence: 81%

Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors – a multicentre case–control study

Heller

Schobeß²,

Kurnik³

et al. 2000

Br J Haematol

View full text Add to dashboard Cite

show abstract

“…This fact was also observed in the present study. Umbilical catheterization, omphalitis and neonatal sepsis are the most common causes in children (2,25,40,42) . The prevalence reported in two other studies was lower than the one observed in this study.…”

Section: Discussionmentioning

confidence: 99%

Portal vein thrombosis in children and adolescents: 20 years experience of a pediatric hepatology reference center

Ferri

Ferreira

Fagundes

et al. 2012

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Context -Portal vein thrombosis refers to a total or partial obstruction of the blood flow in this vein due to a thrombus formation. It is an important cause of portal hypertension in the pediatric age group with high morbidity rates due to its main complication -the upper gastrointestinal bleeding. Objective -To describe a group of patients with portal vein thrombosis without associated hepatic disease of the Pediatric Hepatology Clinic of the Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil with emphasis on diagnosis, presentation form and clinical complications, and the treatment of portal hypertension. Methods -This is a descriptive study of a series of children and adolescents cases assisted from January 1990 to December 2010. The portal vein thrombosis diagnosis was established by ultrasound. Results -Of the 55 studied patients, 30 (54.5%) were male. In 29 patients (52.7%), none of the risk factors for portal vein thrombosis was observed. The predominant form of presentation was the upper gastrointestinal bleeding (52.7%). In 20 patients (36.4%), the initial manifestation was splenomegaly. During the whole following period of the study, 39 patients (70.9%) showed at least one episode of upper gastrointestinal bleeding. The mean age of patients in the first episode was 4.6 ± 3.4 years old. The endoscopic procedure carried out in the urgency or electively for search of esophageal varices showed its presence in 84.9% of the evaluated patients. The prophylactic endoscopic treatment was performed with endoscopic band ligation of varices in 31.3% of patients. Only one died due to refractory bleeding. Conclusions -The portal vein thrombosis is one of the most important causes of upper gastrointestinal bleeding in children. In all non febrile children with splenomegaly and/or hematemesis and without hepatomegaly and with normal hepatic function tests, it should be suspect of portal vein thrombosis. Thus, an appropriate diagnostic and treatment approach is desirable in an attempt to reduce morbidity and mortality.

show abstract

“…For example, prolonged indwelling catheters, respiratory distress, and mechanical ventilation can all increase PLT consumption. [22][23][24][25][26][27] Figure 4 illustrates that thrombocytopenia is more persistent than generally recognized, particularly in the smallest infants. Noninfected, unventilated, AGA infants born at less than 27 weeks gestation exhibited prolonged risk of thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Thrombocytosis and Thrombocytopenia in Hospitalized Neonates

McPherson

Juul

2004

J Perinatol

View full text Add to dashboard Cite

We sought to identify changes in platelet (PLT) counts over time, and to evaluate the patterns of thrombocytopenia and thrombocytosis in hospitalized infants 23.8 weeks to term gestation. STUDY DESIGN:Neonates were divided into four gestational age groups and their PLT counts were retrospectively compared for prevalence of thrombocytopenia, thrombocytosis, and associated conditions. RESULTS:Postconceptional age, postnatal age, and sepsis (among other factors) affected PLT counts. When counts from noninfected appropriately grown infants were evaluated, the risk of thrombocytopenia and thrombocytosis were highest in the most preterm infants, and these risks changed with corrected gestational age. PLT counts increased weekly over the first 4 weeks of life for all but the most preterm infants. CONCLUSIONS:These data characterize the incidence of thrombocytopenia and thrombocytosis across a wide range of gestational ages and show that, even in noninfected neonates, these conditions are common, and risk decreases with increasing maturity. The age-related changes in PLT patterns may reflect maturation of platelet regulation.

show abstract

Umbilical venous catheterization and the risk of portal vein thrombosis

Cited by 75 publications

References 12 publications

Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors – a multicentre case–control study

Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors – a multicentre case–control study

Portal vein thrombosis in children and adolescents: 20 years experience of a pediatric hepatology reference center

Patterns of Thrombocytosis and Thrombocytopenia in Hospitalized Neonates

Contact Info

Product

Resources

About