Umsatz und Stoffwechsel der Schilddrüsenhormone

Klein, Erich

doi:10.1007/978-3-662-26787-5_2

Cited by 6 publications

(1 citation statement)

References 86 publications

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“…The mean normal concentration of thyroxine in serum is 8.5 (ig/100 ml (normal range: 5-12 [igl 100 ml). It is assumed that the ratio of serum thyroxine concentration to thyroxine pool is constant, as the distribution volume of thyroxine is nearly unchanged in hyperthyroidism (14). In the course of our calculations the serum thyroxine concentration at each time tn is determined by the ratio 1:70.6.…”

Section: Juo |U20mentioning

confidence: 99%

The Influence of Elevated Iodide Supply on the Autonomously Functioning Thyroid Gland

Waters¹,

Kutzim²,

Wellner³

1984

Nuklearmedizin

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SummaryA pharmacokinetic two-compartment model of iodine metabolism has been established on the basis of data from the literature and our own experimental investigations. By this model it is possible to estimate the effects either of prolonged elevation of iodide supply or of a single administration of a high dose of inorganic iodide in the presence of autonomously functioning thyroid tissue. Prolonged elevation of iodide supply in regions of iodine deficiency will cause manifest hyperthyroidism in many cases of thyroidal autonomy (cases with facultative hyperthyroidism). The administration of a single high dose of iodide, as it is proposed for the situation of an accident in a nuclear power station (100 mg Nal) in order to reduce the radiation burden to the surrounding population, carries almost no risk in cases of thyroid autonomy.

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Section: Juo |U20mentioning

confidence: 99%