UN millennium development goals: Can we halt the stroke epidemic in India?

Dalal, P. M.; Bhattacharjee, Maumita; Vairale, Jaee; Bhat, Priya

doi:10.4103/0972-2327.34791

Cited by 61 publications

(39 citation statements)

References 1 publication

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“…India is a developing economy, where ageing population, changes in lifestyle and rapid urbanization have contributed to a rise in noncommunicable diseases, including stroke. 16 In India and other developing countries, an alarming increase in the incidence of stroke has been observed.…”

mentioning

confidence: 99%

Financial burden of stroke on family and caregiver in India: a literature review

Mishra

Mishra²,

Gajjar

2016

Int J Res Med Sci

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mentioning

confidence: 99%

Financial burden of stroke on family and caregiver in India: a literature review

Mishra

Mishra²,

Gajjar

2016

Int J Res Med Sci

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“…Study estimates state that approximately 20 million people suffer from stroke out of which only 15 million survive [3]. Due to the fact that developed countries have effective screening, evaluation and therapies for stroke against the developing countries have led to high death rates in developing countries due to stroke.…”

Section: Ischemic Stroke: the Global And Indian Scenariomentioning

confidence: 99%

A Review on Recombinant Tissue Plasminogen Activator: <i>In Vitro</i> Synthesis and Its Use in Treatment of Acute Ischemic Stroke

Sukumaran¹,

Poulse²

2014

OALib

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Tissue-type Plasminogen Activator (tPA) is a serine protease produced by endothelial cells. They target plasminogen, an inactive precursor of plasmin and convert the plasminogen into active plasmin, which degrades the fibrin component of thrombus to aid in dissolution of blood clots. Hence tPA is commonly used in treatment of acute Ischemic stroke in the form of recombinant tissue plasminogen activator (rtPA). rtPA is produced using recombinant technology from different types of vectors depending on the quantities required for the treatment of different diseases. Alteplase (intravenous rtPA) is the most common therapy drug used to treat ischemic strokes. This review gives an outline of the in vitro synthesis of rtPA and its usage in treatment of Acute Ischemic stroke.

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“…1 Approximately 20 million people each year will suffer from stroke and of these 5 million will not survive. 2 Stroke is no longer a disease of the developed world: Low and middle-income countries account for 85.5% of total stroke deaths worldwide and the number of disability-adjusted life years in these countries was approximately seven times that in highincome countries. 3 In India, the estimated adjusted prevalence rate of stroke range, 84-262/100,000 in rural and 334-424/100,000 in urban areas.…”

Section: Introductionmentioning

confidence: 99%

Clinical study of acute stroke with special reference to Greek stroke scoring system

Saini

Singh

2017

Int J Res Med Sci

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Background: Stroke is becoming an important cause of premature death and disability in low-income and middle-income countries like India, largely driven by demographic changes and enhanced by the increasing prevalence of the key modifiable risk factors. Rapid access to CT is virtually impossible for all patients with a cerebrovascular event especially in resource poor countries like ours. Aims and objectives of the study were to study the clinical characteristics of patients suffering from acute stroke and to study the efficacy of Greek stroke scoring system in differentiating acute intracerebral infarction and hemorrhagic strokeMethods: Present study was carried out in 50 consecutive patients of stroke admitted to department of Medicine, Guru Nanak Dev Hospital (attached to Government Medical College), Amritsar, Punjab, India. It was a prospective, observational, hospital based study.Results: Maximum number of stroke patients i.e. 36% were in the age group of 61-70 years. Mean±sd age for ischemic and hemorrhagic stroke was 67.9±11 and 57±9 years respectively. 36 patients (72%) had ischemic stroke and hemorrhagic stroke was seen in 14 patients (28%). Among the modifiable risk factors of stroke-hypertension was the most common (68% cases) followed by dyslipidemia (64%), DM (30%), chronic alcohol intake (28%). In the present study, Greek score had a high sensitivity (97%) and positive predictive value (97%) in diagnosing ischemic stroke. It also had excellent specificity (97%) and negative predictive value (97%) in diagnosing hemorrhagic strokeConclusions: Targeting the risk factors for preventing stroke in the first place will help in reducing burden of this often-disabling disease. The CT scan remains as a gold standard in differential diagnosis of stroke and Greek scoring system may be used as a guide in management only when resources are limited and CT scan facilities are not available.

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UN millennium development goals: Can we halt the stroke epidemic in India?

Cited by 61 publications

References 1 publication

Financial burden of stroke on family and caregiver in India: a literature review

Financial burden of stroke on family and caregiver in India: a literature review

A Review on Recombinant Tissue Plasminogen Activator: <i>In Vitro</i> Synthesis and Its Use in Treatment of Acute Ischemic Stroke

Clinical study of acute stroke with special reference to Greek stroke scoring system

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