We present general principles for the design and analysis of unbiased Monte Carlo estimators for quantities such as α = g (E (X)), where E (X) denotes the expectation of a (possibly multidimensional) random variable X, and g (·) is a given deterministic function. Our estimators possess finite work-normalized variance under mild regularity conditions such as local twice differentiability of g (·) and suitable growth and finite-moment assumptions. We apply our estimator to various settings of interest, such as optimal value estimation in the context of Sample Average Approximations, and unbiased steady-state simulation of regenerative processes. Other applications include unbiased estimators for particle filters and conditional expectations.