UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway

Li, Honghai; Song, Xian-Xu; Liu, Bo; Yang, Wenping

doi:10.1080/03639045.2019.1607870

Cited by 3 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ERK1/2 activation can be detected in various autophagic processes and can influence the proliferation of tumor cells via autophagy (26,27). p-ERK1/2 proteins directly phosphorylate the S664 residue of the tuberin protein, thereby inhibiting autophagy (36).…”

Section: Discussionmentioning

confidence: 99%

“…To determine the possible mechanisms of autophagy regulation, western blot analysis was performed to detect the expression of the autophagy regulator proteins Beclin 1 and ERK in Hep-G2 cells. Beclin 1 is an important protein involved in the regulation of autophagy and the activation of ERK1/2 can be detected in numerous autophagic processes (26,27). The protein expression of Beclin 1 increased significantly by 44% in Hep-G2 cells following the addition of 2 µM HSYA for 6 h. The levels of Beclin 1 protein expression increased slightly at 24 h compared with the control group ( Fig.…”

Section: Hsya Affects Autophagy By Regulating the Expression Of Beclimentioning

confidence: 91%

See 1 more Smart Citation

Hydroxysafflor yellow�A induces autophagy in human liver cancer cells by regulating Beclin�1 and ERK expression

Chen

Liu

et al. 2020

Exp Ther Med

View full text Add to dashboard Cite

Hydroxysafflor yellow A (HSYA) is a water-soluble component of the safflower (Carthamus tinctorius), and research has revealed that HSYA exhibits antitumor effects. In the present study, the effects of HSYA on the autophagy of a Hep-G2 liver cancer cell line, as well as the underlying mechanisms, were investigated. Hep-G2 cells were treated with HSYA and the viability of cells was measured using an MTT assay. Western blotting and immunofluorescence assays were performed to determine the expression of light chain 3 II (LC3-II) and p62, as well as the autophagy regulators Beclin 1 and ERK1/2. Transmission electron microscopy was performed to observe the formation of autophagosomes. The combined effects of HSYA and the autophagy inhibitor chloroquine (CQ) were also determined. The results revealed that the viability of Hep-G2 cells decreased with increasing concentrations of HSYA. Furthermore, LC3-II expression increased significantly and the level of p62 decreased significantly in the HYSA group compared with the control group. Additionally, an increase in Beclin 1 expression and a decrease in phosphorylated-ERK1/2 expression was observed in Hep-G2 cells treated with HYSA. Following treatment with CQ and HSYA, a significant increase in the viability of Hep-G2 cells was observed compared with the HSYA group. Collectively, the results indicated that HSYA induced autophagy by promoting the expression of Beclin 1 and inhibiting the phosphorylation of ERK in liver cancer cells. Therefore, HSYA may serve as a potential therapeutic agent for liver cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Hsya Affects Autophagy By Regulating the Expression Of Beclimentioning

confidence: 91%

Hydroxysafflor yellow�A induces autophagy in human liver cancer cells by regulating Beclin�1 and ERK expression

Chen

Liu

et al. 2020

Exp Ther Med

View full text Add to dashboard Cite

show abstract

Tetrahydro-β-carboline-naphthalimide hybrids: Synthesis and anti-proliferative evaluation on estrogen-dependent and triple-negative breast cancer cells

Shalini

Lata

Saha

et al. 2022

Journal of Molecular Structure

View full text Add to dashboard Cite

Polyamine-modified naphthalimide derivative 9C inhibits colorectal cancer through ROS-mediated ER stress, migration and invasion

Xu,

Ge,

Wang

et al. 2025

Toxicology in Vitro

View full text Add to dashboard Cite

UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway

Cited by 3 publications

References 36 publications

Hydroxysafflor yellow�A induces autophagy in human liver cancer cells by regulating Beclin�1 and ERK expression

Hydroxysafflor yellow�A induces autophagy in human liver cancer cells by regulating Beclin�1 and ERK expression

Tetrahydro-β-carboline-naphthalimide hybrids: Synthesis and anti-proliferative evaluation on estrogen-dependent and triple-negative breast cancer cells

Polyamine-modified naphthalimide derivative 9C inhibits colorectal cancer through ROS-mediated ER stress, migration and invasion

Contact Info

Product

Resources

About