This study investigates the effects of global economic uncertainties on exchange rate management in Africa from 1990 to 2021. Employing the quantile regression technique, findings show that both global and domestic economic uncertainties have significant influence on exchange rate management in Africa. The intensity of global economic uncertainty rises during the bearish and transitional markets, but dependence declines during the bullish markets. Moreover, the relationship between domestic uncertainty and African exchange rate management shows that the structure of dependence improves around the upper tails but declines around the lower tails. African countries should pay attention to global economy in order to combat any impending negative effects of global economic uncertainties. Also, attention should be paid to other uncertainties such as political, social, or other factors that may aggravate domestic economic uncertainties.