Design for additive manufacturing (DFAM) seeks to develop designs that take advantage of the unique capabilities of additive manufacturing (AM) processes to maximize benefits. In this paper, several issues at the frontier of DFAM research are highlighted. First, the need is described to include as-manufactured mechanical and other physical properties, such as topology and shape optimization and generative design, during computational design. AM processes rarely produce parts with homogeneous composition and isotropic properties, so design methods and tools should not assume them. Second, the topic of designing for the AM process chain is important since AM-fabricated parts typically need postprocessing operations, such as support removal, finish machining, heat treatments, etc. DFAM methods need to incorporate the entire process chain, not just the AM process, which is explored with an example from metal powder bed fusion. Third, potentially, the largest benefit of AM can be realized by radically rethinking product architectures. Examples of an electric motorcycle and an assistive exosuit illustrate the ideas and potential benefits. Finally, some thoughts on design for 4D printing are offered, specifically for 3D printed morphing and deployable systems that utilize the shape memory effect.