Uncommon affliction of a common disease - primary tuberculosis of thyroid gland

Majumder, Anusree; Sen, Debraj

doi:10.4103/ijpm.ijpm_719_18

Cited by 4 publications

(7 citation statements)

References 6 publications

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“…9 In a few cases, thyroid damage has been found to be caused by M. tuberculosis or even by thyrotoxicosis or mucoedema. 10 Most researchers believe that the granulomatous type is the most common type in clinical practice, while a few researchers believe that the caseous type is the most common. Among the nine patients with PTT in our study, six were considered to be the granulomatous type; two, the caseous type; and one, the diffuse type.…”

Section: Discussionmentioning

confidence: 99%

Clinical diagnosis and treatment of primary thyroid tuberculosis: a retrospective study

Sun

Dong

et al. 2022

Sao Paulo Med. J.

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BACKGROUND: Primary thyroid tuberculosis (PTT) is an uncommon type of extrapulmonary tuberculosis, which is caused by Mycobacterium tuberculosis. It does not have specific clinical manifestations, and most cases are diagnosed through postoperative histopathological examination. OBJECTIVE: To evaluate the diagnostic pattern and management strategy among patients with primary thyroid tuberculosis. DESIGN AND SETTING: Retrospective study on patients with primary thyroid tuberculosis in the First Hospital of Jilin University (Changchun, China). METHODS: Between March 2015 and June 2020, nine cases of PTT were diagnosed and treated in the Department of Thyroid Surgery of the First Hospital of Jilin University. Age at diagnosis, primary symptoms, preoperative biopsy, operation method, pathological classification, acid-fast staining test, anti-TB therapy and prognosis were registered in order to explore the appropriate protocol for diagnosis and treatment of this disease. RESULTS: None of the patients was diagnosed with thyroid tuberculosis before surgery. All the patients underwent surgery. Granulomatous changes or caseous necrosis in thyroid tissue were found through postoperative histopathological evaluation. Polymerase chain reaction (PCR) results for Mycobacterium tuberculosis were positive in all patients. Most patients had a good prognosis after surgery and anti-tuberculosis drug therapy. CONCLUSION: PTT is a rare disease. It is important to improve the preoperative diagnosis. Preoperative diagnostic accuracy relies on increased awareness of the disease and appropriate use of preoperative diagnostic methods, such as PCR detection, fine-needle aspiration cytology, acid-fast bacillus culture, ultrasound and blood sedimentation. PCR detection of M. tuberculosis is recommended as the gold standard for diagnosis.

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Section: Discussionmentioning

confidence: 99%

Clinical diagnosis and treatment of primary thyroid tuberculosis: a retrospective study

Sun

Dong

et al. 2022

Sao Paulo Med. J.

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“…6 Imaging techniques such as chest X-ray, USG, computed tomography, and magnetic resonance imaging, although not specific, are extremely helpful in its assessment. 15 The role of FNAC in differentiating all the thyroid lesions is quite well-established. [16][17][18][19][20][21][22] Likewise, cytology is also pivotal in diagnosing thyroid gland TB and preventing unnecessary surgery.…”

Section: Discussionmentioning

confidence: 99%

“…10 Researchers have also suggested that USG guided FNAC should be usually practised in such a case of a highly vascular organ like thyroid gland so as to avoid hemodilution and to get better yield of diagnostic material. 15,24 The characteristic feature of thyroid gland TB on cytology is the presence of caseating epithelioid granulomas accompanied by lymphocytic infiltration and multinucleated Langhan's type giant cells. Although these features can be seen in several other thyroid gland pathologies like de Quervain's thyroiditis etc., nevertheless, caseous necrosis even if focally present should raise a suspicion of TB.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a mycobacterial culture and enzyme amplification (polymerase chain reaction) from the aspirated material can be useful for confirming its diagnosis. 15 In rare instances where FNAC fails in diagnosing thyroid gland TB, the diagnosis is usually made only after histopathological examination of the surgical specimen. 6 However, it has also been mentioned to be an incidental postoperative histopathological surprise after the patients have undergone thyroidectomy for some other cause.…”

Section: Discussionmentioning

confidence: 99%

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Primary thyroid gland tuberculosis: a conundrum in a child

Sharma¹,

Sharma²

2020

MOJS

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“…The primary location is exceptional. The high resistance of the thyroid gland is explained by a very good oxygenation of its parenchyma, by a rich lymphatic drainage system and by a thick fibrous capsule in addition to thyroid hormones and iodine which play a bacteriostatic role 1,4,[30][31][32][33] . In the majority of cases, patients are clinically and biologically euthyroid [31][32][33] , as it was the case for our patient.…”

Section: Thyroid Glandmentioning

confidence: 99%

Extraganglionary Localization of Tuberculosis in Otorhinolaryngology: Rare Presentations About 29 Cases

Benhoummad

Rochd

Yafi

et al. 2022

MRAJ

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The extra nodal tuberculosis is a rare disease in Ear, Nose and Throat. The aim of this work is to study the epidemiological, clinical, therapeutic profiles of rare locations of ENT extra nodal tuberculosis. This is a retrospective study between June 2003 and June 2019, including 29 cases of ENT extra nodal tuberculosis. There were 6 cases of laryngeal tuberculosis, 5 cases of nasopharyngeal tuberculosis, 5 cases of salivary gland tuberculosis, 3 cases of tonsillar tuberculosis, 1 case of tuberculous retropharyngeal abscess, 3 cases of nasal tuberculosis, 3 cases of tuberculosis of the middle ear, 1 case of thyroid tuberculosis, 1 case of tuberculosis of the bony palate, and 1 case of mandibular tuberculosis. All ages were affected with a predominance of young adults. The clinical signs, as well as radiological or endoscopic examinations, were not specific. The diagnosis was based on histology and/or bacteriology. Antibacillary therapy was instaured in all cases. Extra nodal tuberculosis in ENT is rare. It is dominated by the laryngeal location. It must be considered as a differential diagnosis in front of any atypical symptoms, particularly in endemic countries.

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Uncommon affliction of a common disease - primary tuberculosis of thyroid gland

Cited by 4 publications

References 6 publications

Clinical diagnosis and treatment of primary thyroid tuberculosis: a retrospective study

Clinical diagnosis and treatment of primary thyroid tuberculosis: a retrospective study

Primary thyroid gland tuberculosis: a conundrum in a child

Extraganglionary Localization of Tuberculosis in Otorhinolaryngology: Rare Presentations About 29 Cases

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