Uncommon Neosartorya udagawae Fungus as a Causative Agent of Severe Corneal Infection

Posteraro, Brunella; Mattei, Romano; Trivella, Fausto; Maffei, Andrea; Torre, Antonio La; Carolis, Elena De; Posteraro, Brunella; Fadda, Giovanni

doi:10.1128/jcm.00134-11

Cited by 25 publications

(17 citation statements)

References 26 publications

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“…Shigeyasu et al (2012), describen un primer caso de queratitis causado por A.viridinutans, con manifestaciones clínicas distintas a las de A. fumigatus, las cuales incluían resistencia clínica a la anfotericina B y el voriconazol, con baja susceptibilidad a otros agentes fúngicos. Barrs et al (2013) y Nováková et al (2013), demostraron que los casos humanos de aspergilosis invasiva diagnosticados como A.viridinutans por: Coehlo et al 2011;Yaguchi et al 2007;Alcazar-Fuoli, et al 2008;Vinh et al2009;Barrs et al2012Barrs et al -2013Shigeyasu et al 2012;Peláez et al2013, entre otros), corresponden a A.felis, lo que demuestra el aumento de esta especie en clínica junto a A. udagawae (Katz et al 2005;Balajee et al 2006;Vinh et al2009b;Yaguchi et al 2007;Kano et al 2008;Balajee et al2009;Posteraro et al 2011;Gyotoku et al 2012;Kano et al2013).…”

Section: La Sección Fumigati De Aspergillus Con éNfasis En El Complejunclassified

“…Barrs et al (2013) y Nováková et al (2013, demostraron que los casos humanos de aspergilosis invasiva diagnosticados como A.viridinutans por: Coehlo et al 2011;Yaguchi et al 2007; Alcazar-Fuoli, et al 2008; Vinh et al2009; Barrs et al2012 Barrs et al -2013Shigeyasu et al 2012; Peláez et al2013, entre otros), corresponden a A.felis, lo que demuestra el aumento de esta especie en clínica junto a A. udagawae (Katz et al 2005; Balajee et al. 2006; Vinh et al2009b;Yaguchi et al 2007; Kano et al 2008; Balajee et al2009;Posteraro et al 2011; Gyotoku et al. 2012; Kano et al2013).…”

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Notas micológicas XI:Tritirachium oryzae, Paecilomyces formosus y alcances en la Sección Fumigati de Aspergillus con énfasis en el complejo Aspergillus viridinutans

Cruz²,

2013

Bol. Micol.

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Tatarenko: 90 (1952) El géneroTritirachium Limber (sp.tipo T. dependens Limber), contiene principalmente especies anamórficas clasificadas históricamente en la absoleta clase hyphomycetes, posteriormente ubicadas en incertae sedis dentro de los Pezizomycotina (Ascomycota), con 3 especies comúnmente aceptadas (van Beyma 1942; de Hoog 1972;Kirk et al. 2008). La especie tipo, obtenida desde raíces muertas deYucca treculeana Carrière, desde Cuba, fue separada de Verticillium por Limber (1940), y su nueva nominación genérica se basó en la similitud de su conidióforo geniculado al raquis del trigo (Triticum). El género estuvo integrado por otras especies, muchas de ellas actualmente en sinonimía o incluidas en los Clavicipitaceae (MacLeod 1954; de Hoog 1972;Kirk et al. 2008) y aparentemente, solo se reconocen en la actualidad 6, dos de ellas aún no determinadas ( Schell et al., 2011). Estos últimos autores mediante biología molecular con multigenes y 14 aislados, confirmaron que sus linajes no tenían relación con las Clavicipitaceae u otros Ascomycota, sino con los Pucciniomycotina en Basidiomycota (en los nuevos taxas: Tritirachiomycetes, Tritirachiales Tritirachiaceae), los cuales presentan hifas multinucleadas, poro septal simple, conidióforos subhialinos a dematiaceos, con células conidiógenas simpodiales subhialinas a dematiaceas que se presentan en racimos o desordenadas, con conidios sobre un elongado raquis. RESUMEN ABSTRACTEn estas notas micológicas, se comentan los aspectos taxonómicos, ecológicos fisiológicos y moleculares de 2 especies fúngicas filamentosas oportunistas en humanos tales como: Tritirachium oryzae y Paecilomyces formosus, poco conocidas en su distribución en Chile. Al mismo tiempo se aportan datos recientes de la literatura referentes a la distribución y patología de los nuevos integrantes de de la sección Fumigati de Aspergillus, con énfasis en el complejo A. viridinutans, un grupo de especie morfológicamente similares y generalmente oportunista en humanos y animales, las cuales no han sido bien definidas en la últimas décadas.Bol. Micol. 2013; 28(2):58-70 TAXONOMÍA micologia.uv.clIn these notes, taxonomic, ecological, physiological and molecular aspects are discussed of two opportunistic filamentous fungal species in humans, such as Tritirachium oryzae and Paecilomyces formosus, little known in its distribution in Chile. While recent literature data concerning the distribution and pathology of the new members of the Aspergillus section Fumigati contribute, emphasizing the complex A. viridinutans, a group of morphologically similar species and generally opportunistic in humans and animals did, which have not been well defined in recent decades.Teleomorfo desconocido y no descrito en ninguna especie. Shell et al.(2011), comentan que la sola identificación con criterios morfológicos es problemática en el taxon y que sus análisis filogenéticos no soportan la circunscripción existente de algunas especies. Reintroducen T.roseum por ser su extipo claramente diferente de los aislados de T. o...

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Section: La Sección Fumigati De Aspergillus Con éNfasis En El Complejunclassified

unclassified

Notas micológicas XI:Tritirachium oryzae, Paecilomyces formosus y alcances en la Sección Fumigati de Aspergillus con énfasis en el complejo Aspergillus viridinutans

Cruz²,

2013

Bol. Micol.

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“…Although sequencing of the internal transcribed spacer regions was insufficient to identify the isolates to the species level, the high percentage of similarity, the production of ascospores in some mating studies, and the frequent treatment failure suggest that N. udagawae was the main species involved. N. udagawae differs from N. laciniosa in being heterothallic, in failing to grow above 42°C, and in being refractory to antifungal therapy (10,12,13,19).…”

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“…Neosartorya species are generally recognized by their rapidly growing, poorly sporulating white to palegreen colonies in primary culture, by their thermotolerance (all growing at 37°C and a few up to 50°C), and by formation of ascomata containing ascospores on sporulation media. Currently, Neosartorya hiratsukae, Neosartorya pseudofischeri, and Neosartorya udagawae are confirmed as opportunistic pathogens, with the latter species gaining recent attention (5)(6)(7)(8)(9)(10)(11)(12)(13). Although N. fischeri and N. spinosa have been identified in some reports, their roles in causing infection have not been reliably confirmed.…”

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Invasive Sino-Orbital Mycosis in an Aplastic Anemia Patient Caused by Neosartorya laciniosa

et al. 2013

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We report the first case of Neosartorya laciniosa invasive sinusitis involving the orbit in an immunocompromised male with aplastic anemia. Treatment included surgical debridement with enucleation of the eye and combination voriconazole and micafungin therapy followed by voriconazole alone. The fungus was identified using sequencing of partial benA and calmodulin genes. CASE REPORTA 66-year-old male was diagnosed with aplastic anemia in March 2010 and subsequently treated with bone marrow transplant (BMT) followed by immunosuppressive therapy with lymphocyte immune globulin antithymocyte globulin (Atgam; Pfizer Canada Inc., Kirkland, Quebec, Canada), steroids, and cyclosporine. On 19 May 2011, he was referred from a community hospital to the University of Alberta Hospital with a history of pancytopenia (absolute neutrophil count [ANC] of Ͻ500 cells/ l) beginning in February 2011 and intermittent fevers since midApril. Additional findings included increased left-sided periorbital swelling and radiographic evidence of pneumonia, but no respiratory symptoms were evident. He had not received antifungal prophylaxis. On admission, he was hemodynamically stable and febrile (temperature of 39.1°C). A complete blood count (CBC) revealed pancytopenia with a white blood cell count of 400 cells/l (ANC, 0 cells/l) and a creatinine level of 112 mol/liter (estimated glomerular filtration rate, 57 ml/min). Electrolytes and liver enzymes were normal. Urine and blood cultures were negative.The patient was treated empirically with vancomycin and ciprofloxacin for presumed periorbital cellulitis. A computed tomography (CT) scan of the head showed left-sided protposis and progression of fluid and high-density material causing opacification within all of the visualized paranasal sinuses on the left side. This finding was interpreted to represent probable chronic paranasal sinus inflammation. A prior head CT scan done at the time of the BMT was normal. The patient deteriorated clinically with adverse changes, including advancing opacification of frontal, ethmoidal, and maxillary sinuses, with erosions of bony septations of ethmoidal air cells on the left side seen on repeat CT scan on day 6 postadmission. An abscess along the wall of the left medial orbit was documented on CT scan on day 13, and the patient was sent to the operating room the next day for drainage of a subperiostealenhancing fluid collection. Intraoperative tissue samples were sent for pathological analysis as well as for bacterial and fungal cultures. Bacterial culture yielded only coagulase-negative Staphylococcus (CoNS). No fungal elements were seen on direct smear with calcofluor white (BD Diagnostic Systems, Sparks, MD), and fungal cultures were negative. However, the pathology report documented hemorrhagic necrotic sinus mucosal tissue with numerous branched, septate hyphae and focal vascular invasion consistent with invasive fungal infection (Fig. 1A). The patient was promptly started on liposomal amphotericin B (5 mg/kg body weight/day). Tissue from a second de...

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Antifungal Susceptibility Profile of Cryptic Species of Aspergillus

2014

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The use of molecular tools has led to the description of new cryptic species among different Aspergillus species complexes. Their frequency in the clinical setting has been reported to be between 10 and 15%. The susceptibility to azoles and amphotericin B of many of these species is low, and some of them, such as Aspergillus calidoustus or Aspergillus lentulus, are considered multi-resistant. The changing epidemiology, the frequency of cryptic species, and the different susceptibility profiles make antifungal susceptibility testing an important tool to identify the optimal antifungal agent to treat the infections caused by these species.

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Uncommon Neosartorya udagawae Fungus as a Causative Agent of Severe Corneal Infection

Cited by 25 publications

References 26 publications

Notas micológicas XI:Tritirachium oryzae, Paecilomyces formosus y alcances en la Sección Fumigati de Aspergillus con énfasis en el complejo Aspergillus viridinutans

Notas micológicas XI:Tritirachium oryzae, Paecilomyces formosus y alcances en la Sección Fumigati de Aspergillus con énfasis en el complejo Aspergillus viridinutans

Invasive Sino-Orbital Mycosis in an Aplastic Anemia Patient Caused by Neosartorya laciniosa

Antifungal Susceptibility Profile of Cryptic Species of Aspergillus

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