Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-infected women in Southern Brazil

Entiauspe, Ludmila Gonçalves; Seixas, Fabiana Kömmling; Nunes, Emily Montosa; Rodrigues, Fernanda Martins; Dellagostin, Odir A.; Collares, Tiago; Silveira, Mariângela Freitas da

doi:10.1016/j.bjid.2014.07.005

Cited by 8 publications

(9 citation statements)

References 34 publications

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“…This study found a prevalence of 28.4% of HR-HPV among women living with HIV/AIDS in Brazil. This result is lower than data described in previous studies in Rio de Janeiro (50.7%) 18 , Amazonas (61.6%) 19 and Rio Grande do Sul (68.0%) 20 . Some characteristics of these studies can explain the variety in the prevalence rates.…”

Section: Discussioncontrasting

confidence: 77%

“…Similar data was found in the Northeastern Brazil study, where the age < 35 years was more associated with HPV infection, principally with non 16/18 HR‐HPV . This result was different from another study conducted in South Brazil that found higher prevalence of HPV infection in WLHIV with 40 or more years old . However a study in Sub‐Saharan Africa also found higher prevalence of HPV in younger (18‐25) WLHIV, although the authors did not found a tendency of decreasing HPV prevalence with increasing age .…”

Section: Discussionsupporting

confidence: 43%

“…21 This result was different from another study conducted in South Brazil that found higher prevalence of HPV infection in WLHIV with 40 or more years old. 20 However a study in Sub-Saharan Africa also found higher prevalence of HPV in younger (18)(19)(20)(21)(22)(23)(24)(25) WLHIV, although the authors did not found a tendency of decreasing HPV prevalence with increasing age. 23 Generally among women, HPV prevalence decreases with age 24 but this is not necessarily the case for WLHIV.…”

Section: Discussionmentioning

confidence: 90%

“…We also found an association with the presence of HPV and Illicit drug use (OR 1.61). Other studies did not found this association . In the other hand, a nested case‐control in Australia evaluating more than 200,000 women, included about 19,000 drug users, to assess the risk of cervical cancer's precursor lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies did not found this association. 13,20,21 In the other hand, a nested case-control in Australia evaluating more than 200,000 women, included about 19,000 drug users, to assess the risk of cervical cancer's precursor lesions. This study described an association between drug use and less access to be screened for cancer, the presence of HSIL and cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

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High‐risk papillomavirus infection among women living with human Immunodeficiency virus: Brazilian multicentric study

Miranda

Silveira

Travassos³

et al. 2017

Journal of Medical Virology

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Cervical cancer is an important health issue in Latin America. Although HPV infections can have spontaneous clearance, persistence of high-risk (HR) HPV is a risk factor for cervical cancer among women and it is even higher in HIV-infected women. To determine the prevalence of HR-HPV and risk factors among HIV-infected women attending reference services for HIV/AIDS in different regions of Brazil. Cross-sectional study conducted among HIV-infected women attended at referral care centers for HIV/AIDS in nine states of Brazil. Women from 18 to 49 years that accept to participate and were not pregnant at the time of the approach were recruited for the study. The HPV screening was realized using qPCR in closed system, in vitro Diagnostic, COBAS -HPV Roche. The cytology results were available by the Bethesda System. A total of 802(89.1%) from the selected women agreed to participate in the study. Median age was 39(Inter quartile range [IQR34-46]) years and median education was 9(IQR6-11) years. General prevalence of HR-HPV was 28.4%(228/802). HPV-16 prevalence rate was 8.1%(65/802), HPV-18 was 3.7%(30/802) and other types of HR-HPV were 23.6% (189/802). Risk factors for HR-HPV infection in the multivariate logistic regression analysis were: age ranging from 18 to 34 years (OR = 1.43[95%CI:1.18-1.75]), illicit drugs use (OR = 1.61[95%CI:1.10-2.42]) and abnormal cervical cytology (OR = 1.56[95%CI:1.34-1.81]). Results showed a prevalence rate of 28.4% of HR-HPV infection in women living with HIV in Brazil. These infections were significantly associated with having less than 35 years old, illicit drug use and abnormal cervical cytology.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionsupporting

confidence: 43%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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High‐risk papillomavirus infection among women living with human Immunodeficiency virus: Brazilian multicentric study

Miranda

Silveira

Travassos³

et al. 2017

Journal of Medical Virology

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Prevalence and genotype distribution of human papillomavirus in women living with HIV/AIDS in an area of Northeast Brazil

Silva

Santos

et al. 2020

Journal of Medical Virology

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Women infected by human immunodeficiency virus (HIV) are more likely to manifest oncogenic viral infections including human papillomavirus (HPV). It was investigated the HPV prevalence, genotype distribution and HPV relationship with cervical lesions among women living with HIV in Sergipe state, Northeast Brazil. A prevalence survey was conducted including 270 HIV‐infected women who attended the reference center for HIV in Sergipe from August 2014 to November 2017. Cervical samples were processed by the polymerase chain reaction for HPV‐DNA detection. Among the 270 HIV‐infected women, 190 (70.4%) were between 26 and 49 years old and 159 (55.6%) were coinfected with HPV. Among the coinfected women, 24 viral types were identified; 113 (72%) subjects had high‐risk HPV types, and the most prevalent was HPV 16 (53/35.3%). Positive HPV status was statistically associated with having 0 to 8 years of schooling compared with ≥9 years of schooling; and have been diagnosed with HIV infection less than 5 years ago compared with more than 10 years. Cytological abnormalities were found in 13.4% (31/231) of women, most with high‐grade squamous intraepithelial lesions (16/51.6%). However, of women who had no cytological lesions or malignancy (200/86.6%), almost half were HPV DNA‐positive (99/49.5%). In conclusion, the prevalence of HPV among women living with HIV in Sergipe was high. There was a high frequency of high‐risk HPV infection, and a wide diversity of genotypes were detected, with HPV 16 being the most frequent.

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Ethnicity-stratified analysis of the association between P53 rs1042522 polymorphism and women HPV infection: A meta-analysis

Yao²,

et al. 2021

Microbial Pathogenesis

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Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-infected women in Southern Brazil

Cited by 8 publications

References 34 publications

High‐risk papillomavirus infection among women living with human Immunodeficiency virus: Brazilian multicentric study

High‐risk papillomavirus infection among women living with human Immunodeficiency virus: Brazilian multicentric study

Prevalence and genotype distribution of human papillomavirus in women living with HIV/AIDS in an area of Northeast Brazil

Ethnicity-stratified analysis of the association between P53 rs1042522 polymorphism and women HPV infection: A meta-analysis

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