2022
DOI: 10.1042/bsr20211558
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Unconventional metabolites in chromatin regulation

Abstract: Chromatin, the complex of DNA and histone proteins, serves as a main integrator of cellular signals. Increasing evidence links cellular functional to chromatin state. Indeed, different metabolites are emerging as modulators of chromatin function and structure. Alterations in chromatin state are decisive for regulating all aspects of genome function and ultimately have the potential to produce phenotypic changes. Several metabolites such as acetyl-CoA, S-adenosyl methionine (SAM) or adenosine triphosphate (ATP)… Show more

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Cited by 11 publications
(5 citation statements)
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References 191 publications
(257 reference statements)
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“…BASP1 represses transcription through a novel mechanism that requires its lipidation to recruit PIP 2 and cholesterol to the promoter region of target genes. The localization of lipids, including PIP 2 and cholesterol, within the nucleus as well as their association with chromatin is well-documented, but their roles in nuclear processes are poorly understood ( Garcia-Gil and Albi, 2017 ; Fernandes et al., 2018 ; Fiume et al., 2019 ; Barbosa and Siniossoglou, 2020 ; Gapa et al., 2022 ). Here we have presented evidence that myristoylated BASP1 is recruited to the promoter of WT1 target genes.…”
Section: Discussionmentioning
confidence: 99%
“…BASP1 represses transcription through a novel mechanism that requires its lipidation to recruit PIP 2 and cholesterol to the promoter region of target genes. The localization of lipids, including PIP 2 and cholesterol, within the nucleus as well as their association with chromatin is well-documented, but their roles in nuclear processes are poorly understood ( Garcia-Gil and Albi, 2017 ; Fernandes et al., 2018 ; Fiume et al., 2019 ; Barbosa and Siniossoglou, 2020 ; Gapa et al., 2022 ). Here we have presented evidence that myristoylated BASP1 is recruited to the promoter of WT1 target genes.…”
Section: Discussionmentioning
confidence: 99%
“…BASP1 represses transcription through a novel mechanism that requires its lipidation to recruit PIP2 and cholesterol to the promoter region of target genes. The localization of lipids, including PIP2 and cholesterol, within the nucleus as well as their association with chromatin is well-documented, but their roles in nuclear processes are poorly understood (Garcia-Gil et al, 2017; Fernandes et al, 2018; Fiume et al, 2019; Barbosa and Siniossoglou, 2020; Gapa et al 2022). Here we have presented evidence that myristoylated BASP1 is recruited to the promoter of WT1 target genes.…”
Section: Discussionmentioning
confidence: 99%
“…Histone PTMs can alter the charge density between histones and DNA, resulting in modulating chromatin compaction and regulating gene expressions 27,28 , and thus their dysregulations play crucial roles in tumor. We analyzed the potential role of histone dopaminylation in neuroblastoma, the most common extracranial solid tumor in children causing 12-15% of cancer-related deaths in early childhood 2,[29][30][31][32] .…”
Section: Functional Investigation Of Histone H4 Dopaminylation (H4q27...mentioning
confidence: 99%