Undercarboxylated osteocalcin is associated with insulin resistance, but not adiponectin, during pregnancy

Srichomkwun, Panudda; Houngngam, Natnicha; Pasatrat, S; Tharavanij, Thipaporn; Wattanachanya, Lalita; Khovidhunkit, Weerapan

doi:10.1007/s12020-015-0829-x

Cited by 10 publications

(14 citation statements)

References 25 publications

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“…Among the 806 articles retrieved, 31 were eligible; 14 were FABP4 studies [ 8 , 17 – 19 , 26 – 36 ], seven were nesfatin-1 studies [ 10 , 12 , 20 , 37 – 40 ], seven were OC studies [ 14 , 21 , 41 – 45 ], and three articles covered both FABP4 and nesfatin-1 [ 11 , 46 , 47 ]. The 31 studies involved 4590 participants; 2059 were GDM patients and 2531 were healthy pregnant women [ 8 , 10 – 12 , 14 , 17 – 21 , 26 – 47 ] (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Although the potential roles of circulating FABP4, nesfatin-1, and OC in GDM have been the focus of research in recent decades, the results have been controversial due to different ethnicities, assay methods, and diagnostic/definition of GDM [ 17 – 21 ]. Therefore, the primary goal of this research was to obtain more comprehensive results to elucidate the association between circulating concentrations of these adipokines and women with GDM.…”

Section: Introductionmentioning

confidence: 99%

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Circulating FABP4, nesfatin-1, and osteocalcin concentrations in women with gestational diabetes mellitus: a meta-analysis

Sun

Zhang

et al. 2020

Lipids Health Dis

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Objective: Recent studies have investigated the circulating adipocyte fatty acid binding protein (FABP4), nesfatin-1, and osteocalcin (OC) concentrations in women diagnosed with gestational diabetes mellitus (GDM), but the findings prove to be conflicting. The objective of this research was to systematically assess the relationship of circulating levels of above adipokines with GDM. Methods: Pubmed, Embase, Web of Science, Cochrane library, OVID, and Scopus were performed to locate articles published up to January 31, 2020. Pooled standard mean differences (SMDs) with 95% confidence intervals (CIs), and 95% predictive intervals (PIs) were calculated by random-effects models to compare levels of adipokines between GDM cases and control groups. Cumulative and single-arm meta-analyses were also performed. Results: Thirty-one studies comprising 4590 participants were included. No significant differences were found between GDM women and healthy controls in circulating nesfatin-1 levels (4.56 vs. 5.02 ng/mL; SMD = − 0.11, 95% CI-0.61-0.38, 95% PI-1.63-1.41). Nevertheless, circulating FABP4 and OC levels observed in GDM women outnumbered normal controls (FABP4, 23.68 vs. 16.04 ng/mL; SMD = 2.99, 95% CI 2.28-3.69, 95% PI 0.28-5.71; OC, 52.34 vs. 51.04 ng/mL; SMD = 0.68, 95% CI 0.31-1.05, 95% PI-0.48-1.84). The cumulative meta-analysis showed that the SMDs of circulating FABP4 and OC levels had stabilized between the two groups. Conclusions: Elevated circulating FABP4 and OC levels were observed in GDM women, but nesfatin-1 levels did not change, the PI of OC crossed the no-effect threshold. The results suggested that FABP4 is more suitable as a biomarker of GDM compared to OC in a future study, which is useful in identifying pregnant women who are likely to develop GDM and providing prompt management strategies.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating FABP4, nesfatin-1, and osteocalcin concentrations in women with gestational diabetes mellitus: a meta-analysis

Sun

Zhang

et al. 2020

Lipids Health Dis

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“…A unique role for undercarboxylated OC (ucOC) in regulating energy metabolism has been proposed based on observations that ucOC injection improved insulin resistance and reduced fat mass in osteocalcin knockout and wild‐type mice. Attempts to translate these findings to humans have yielded equivocal results . More recently, an additional role for ucOC in enhancing skeletal muscle mass and function has been suggested because mice lacking a neuromuscular gap junction protein (connexin43) that were injected with human ucOC had increased muscle area and grip strength compared with the same knockout mice injected with saline …”

Section: Introductionmentioning

confidence: 99%

“…Attempts to translate these findings to humans have yielded equivocal results. (6)(7)(8)(9)(10)(11)(12)(13) More recently, an additional role for ucOC in enhancing skeletal muscle mass and function has been suggested because mice lacking a neuromuscular gap junction protein (connexin43) that were injected with human ucOC had increased muscle area and grip strength compared with the same knockout mice injected with saline. (14) UcOC is reduced by vitamin K supplementation.…”

Section: Introductionmentioning

confidence: 99%

Reducing Undercarboxylated Osteocalcin With Vitamin K Supplementation Does Not Promote Lean Tissue Loss or Fat Gain Over 3 Years in Older Women and Men: A Randomized Controlled Trial

Shea

Dawson‐Hughes

Gundberg

et al. 2016

Journal of Bone and Mineral Research

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Osteocalcin (OC) is a vitamin K-dependent protein synthesized during bone formation. Mice injected with the undercarboxylated form of OC (ucOC) had more skeletal muscle mass and less fat mass than sham-treated controls, suggesting a unique metabolic role for ucOC. UcOC decreases in response to vitamin K supplementation. Our objective was to determine the effect of reducing ucOC on change in lean tissue and fat mass in older community-dwelling adults (n=401, mean±SD 69±6 years) using data from a randomized controlled trial of vitamin K supplementation Over 3 years, serum ucOC was reduced by 58% in women and by 61% in men randomized to vitamin K, while in the control group ucOC decreased by 1% in women and 4% in men (supplementation*time p<0.001 in men and women). However, there were no differences in the change in appendicular lean mass (calculated as arm lean mass + leg lean mass)or total body fat mass between women randomized to vitamin K and control over 3 years (supplementation*time p-values all ≥0.18)or between men randomized to vitamin K and control (supplementation*time p-values all ≥0.54). Consistent with these findings, ucOC was not associated cross-sectionally with appendicular lean mass or fat mass in men or women after adjustment for total OC at baseline (all p ≥0.12). These findings indicate the undercarboxylated form of OC is not implicated in age-related changes in skeletal muscle or adipose tissue mass in older community-dwelling adults.

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“…The OC levels reflect directly the bone turnover, whose measurement is strongly correlated with the actual state of bone metabolism. Increased levels of OC are observed in bone diseases associated with increased bone turnover, such as Paget's disease and metastatic cancers (1)(2)(3). The OC levels in type II diabetes mellitus (DM) are negatively correlated with increased insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Serum Osteocalcin Level and Gestational Diabetes Mellitus: A Case-Control Study

Peivandi

Yaghoubinia

Kashi

et al. 2020

Ethiop J Health Sci

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BACKGROUND: Osteocalcin (OC) is the most common noncollagenous protein in bone matrix, which is synthesized only in bone tissue and by osteoblasts. The potential role of osteocalcin on glucose and fat metabolism has been previously reported. The aim of this study was to compare the serum OC level in pregnant women with and without gestational diabetes mellitus (GDM).METHODS: In the present case-control study, all pregnant women who were referred to a obstetrics and gynecology clinic in Sari, Iran, and met the inclusion criteria underwent an overall screening with a 75-g glucose tolerance test (GTT) at week 24 to 28 of gestation. The study was conducted between September 2018 and February 2019. Based on criteria, the pregnant women with confirmed GDM were matched with pregnant women without GDM in terms of baseline characteristics such as chronological age and BMI. The serum OC levels were also measured if vitamin D and calcium levels were normal. All data were analyzed using SPSS 21.RESULTS: The two groups with and without GDM had no significant difference in terms of age, BMI and OC level. There was no significant correlation between age and BMI with OC level in healthy pregnant women, respectively (P=0.49 and P=0.58). The correlation between BMI and age with OC level in GTT-positive pregnant women was 0.05 and -0.172, respectively, which was not significant (P=0.77 and P=0.36).CONCLUSION: According to the results of this study, there is no significant difference of serum OC levels in pregnant women with GDM compared to healthy pregnancy. Given that the levels of serum insulin or insulin resistance have not been assessed, these indices are recommended to be evaluated in future studies.

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Undercarboxylated osteocalcin is associated with insulin resistance, but not adiponectin, during pregnancy

Cited by 10 publications

References 25 publications

Circulating FABP4, nesfatin-1, and osteocalcin concentrations in women with gestational diabetes mellitus: a meta-analysis

Circulating FABP4, nesfatin-1, and osteocalcin concentrations in women with gestational diabetes mellitus: a meta-analysis

Reducing Undercarboxylated Osteocalcin With Vitamin K Supplementation Does Not Promote Lean Tissue Loss or Fat Gain Over 3 Years in Older Women and Men: A Randomized Controlled Trial

Relationship between Serum Osteocalcin Level and Gestational Diabetes Mellitus: A Case-Control Study

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