Understanding and Treating Tardive Dyskinesia

Jeste, Dilip V.; Wyatt, Richard Jed; Tupin, Joe P.

doi:10.1097/00004714-198306000-00037

Cited by 154 publications

(55 citation statements)

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“…Assessments of psychiatric symptom severity, performance-based functional capacity, neuropsychological performance, and subjective and objective QOL were administered to all participants at the baseline assessment, before any treatment was provided, by examiners trained to a high level of interrater reliability (ICCs>.90). Antipsychotic medication dosages were converted into chlorpromazine equivalents (CPZE) according to standard formulae (Jeste and Wyatt, 1982;Woods, 2003), except for participants taking clozapine or long-acting injectable medications (n=10), for which conversion formulae do not exist.…”

Section: Methodsmentioning

confidence: 99%

Subjective and objective quality of life in schizophrenia

Narvaez¹,

Twamley²,

McKibbin³

et al. 2008

Schizophrenia Research

227

139

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Objective-Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually defined as participation in activities and relationships). We examined separately the clinical, functional, and cognitive predictors of subjective and objective QOL in outpatients with schizophrenia. We hypothesized that better subjective QOL would be associated with less severe negative and depressive symptoms, better objective QOL, and greater everyday functioning capacity, and that better objective QOL would be associated with less severe negative and depressive symptoms, better cognitive performance, and greater functional capacity.Method-Participants included 88 outpatients with schizophrenia or schizoaffective disorder who completed a comprehensive series of assessments, including measures of positive, negative, and depressive symptoms; performance-based functional skills; a neuropsychological battery; and an interview measure of subjective and objective QOL.Results-In the context of multiple predictor variables, more severe depressive symptoms and better neuropsychological functioning were independent predictors of worse subjective QOL. More severe negative symptoms predicted worse objective QOL. Functional capacity variables were not associated with subjective or objective QOL.Conclusion-Treatments to improve QOL in schizophrenia should focus on negative symptoms and depressive symptoms.

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Section: Methodsmentioning

confidence: 99%

Subjective and objective quality of life in schizophrenia

Narvaez¹,

Twamley²,

McKibbin³

et al. 2008

Schizophrenia Research

227

139

View full text Add to dashboard Cite

show abstract

“…Examiners were trained to a high level of interrater reliability (ICCs>.90). Antipsychotic medication dosages were converted into CPZE according to standard formulae (Jeste and Wyatt, 1982;Woods, 2003), except for participants taking clozapine or long-acting injectable medications (n=3), for which conversion formulae do not exist.…”

Section: Methodsmentioning

confidence: 99%

Neuropsychological substrates and everyday functioning implications of prospective memory impairment in schizophrenia

Twamley¹,

Woods²,

Zurhellen³

et al. 2008

Schizophrenia Research

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Individuals with schizophrenia demonstrate impairment in prospective memory (ProM), which describes the multifaceted ability to execute a future intention. Despite its clear implications for everyday functioning, the neuropsychological substrates and functional correlates of ProM impairment in schizophrenia remain poorly understood. In this study, the Memory for Intentions Screening Test (MIST), a standardized measure of ProM, was administered to 72 outpatients with schizophrenia or schizoaffective disorder as part of a comprehensive neuropsychological and psychiatric research evaluation. Results showed that ProM was positively correlated with standard clinical tests of attention, working memory, processing speed, learning, and executive functioning, but not delayed recall. In the context of multiple neuropsychological predictors, learning ability was the only domain that independently contributed to ProM. Importantly, better ProM was predictive of higher functional capacity (as measured by the UCSD Performance-Based Skills AssessmentBrief Version), above and beyond the variability explained by demographic and disease factors. Analysis of component processes revealed that event-based ProM, as well as no response (i.e., omission) and task substitution errors were the strongest predictors of everyday functioning. Overall, these findings suggest that ProM impairment in schizophrenia is associated with multiple cognitive substrates, particularly episodic learning deficits, and plays an important role in everyday living skills. Studies regarding the potential effectiveness of ProM-based remediation strategies to improve functional outcomes in schizophrenia are indicated.

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“…Antipsychotic Medication Doseage-We conducted chart reviews of medication use (i.e., amounts, types, and frequencies of antipsychotic medication use). Typical and atypical medications were converted to mg chlorpromazine equivalents using published formulae (Jeste & Wyatt, 1982;Woods, 2003).…”

Section: Classification Of Livingmentioning

confidence: 99%

Usefulness of the UCSD performance-based skills assessment (UPSA) for predicting residential independence in patients with chronic schizophrenia

Mausbach

Bowie

Harvey

et al. 2008

Journal of Psychiatric Research

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116

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The objective of this study was to examine the sensitivity and specificity of a performance-based measure of functional capacity, the UCSD Performance-Based Skills Assessment (UPSA) for the prediction of independent living status in patients with chronic schizophrenia-related conditions. A sample of 434 adults with schizophrenia or schizoaffective disorder was administered the UPSA and assessed for independent living status. Participants were classified as "independent" if they were living alone in an apartment, house, or single-resident occupancy (e.g., hotel room) and nonindependent if they resided in a care facility (e.g., Board-and-Care home, Skilled Nursing Facility). Receiver Operator Characteristic (ROC) curves were calculated with the UPSA and Mattis' Dementia Rating Scale (DRS) scores as predictor variables and residential independence as the state variable. Of the 434 participants, 99 (23%) were living independently at the time of assessment. The discriminant validity of the UPSA was adequate (ROC area under the curve = 0.74; 95% CI: 0.68-0.79), with greatest dichotomization for the UPSA at a cutoff score of 75 (68% accuracy, 69% sensitivity, 66% specificity), or 80 (68% accuracy, 59% sensitivity, 76% specificity). The UPSA was also a significantly better predictor of living status than was the DRS, based on ROC (z = 2.43, p = . 015). The UPSA is a brief measure of functional capacity that predicts the ability of patients with schizophrenia to reside independently in the community.

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Understanding and Treating Tardive Dyskinesia

Cited by 154 publications

References 0 publications

Subjective and objective quality of life in schizophrenia

Subjective and objective quality of life in schizophrenia

Neuropsychological substrates and everyday functioning implications of prospective memory impairment in schizophrenia

Usefulness of the UCSD performance-based skills assessment (UPSA) for predicting residential independence in patients with chronic schizophrenia

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