Understanding arsenic carcinogenicity by the use of animal models

Wanibuchi, Hideki; Salim, Elsayed I.; Kinoshita, Anna; Shen, Jun; Wei, Min; Morimura, Keiichirou; Yoshida, Kaoru; Kuroda, Koichi; Endo, Ginji; Fukushima, Shoji

doi:10.1016/j.taap.2003.10.032

Cited by 77 publications

(42 citation statements)

References 43 publications

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“…DMA (V) has shown genotoxic effects on cultured mammalian cells [115,124], and in animal studies been reported to promote carcinogenic effects in the urinary bladder, kidney, liver and the thyroid gland [125,126]. Both MA (V) and DMA (V) has been classified as "possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer (IARC) [127].…”

Section: Mechanisms and Toxicity Of Arsenic Compounds Occurring In Sementioning

confidence: 99%

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Molin

Ulven

Meltzer

et al. 2015

Journal of Trace Elements in Medicine and Biology

196

105

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Section: Mechanisms and Toxicity Of Arsenic Compounds Occurring In Sementioning

confidence: 99%

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Molin

Ulven

Meltzer

et al. 2015

Journal of Trace Elements in Medicine and Biology

196

105

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show abstract

“…In contrast, more recent data from animal models have shown the possibility of a strong bond with liver tumor formation [261][262][263][264][265][266][267][268] . Various carcinogenic mechanisms, genetic and epigenetic, have been proposed: DNA methylation, oxidative damage, genomic instability and reduction of programmed cell death [269][270][271][272][273][274] .…”

Section: Arsenicmentioning

confidence: 99%

Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic steatohepatitis, obesity, type 2 diabetes, cirrhosis, aflatoxin, hemochromatosis, Wilson's disease and hemophilia. Occupational exposure to chemicals is another risk factor for HCC. Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent. This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. Core tip: Hepatocellular carcinoma (HCC) is the fifth most common human cancer. This review summarizes current knowledge regarding the occupational risk factors of HCC. In particular, we underline not only the infective but also non-infective occupational risk exposure, including chemical agents and toxic metabolites which are a major cause of liver damage.

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“…The existing animal models of bladder tumorigenesis include rodents, rabbits, and dogs in which bladder tumors can be induced in vivo by administering known bladder carcinogens, e.g., aromatic amines [75][76][77][78] and arsenic. 78,79 The advent of high throughput genome-wide technologies for DNA methylation detection will be instrumental in establishing the genomic distribution of aberrant DNA methylation at various stages of bladder carcinogenesis. 32,44,65,69 Such an approach will verify the compared with 69 urine samples from age-matched control subjects.…”

Section: Investigating the Mechanistic Involvement Of Aberrant Dna Mementioning

confidence: 99%