Understanding cancer-related fatigue: advancing the science

Renner, Michael; Saligan, Leorey N.

doi:10.1080/21641846.2016.1246513

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…In contrast, ibrutinib treatment with ALA, melatonin, and resveratrol significantly up-regulates the expression of BAX (range 2-fold to 3.4-fold) and CASP3 (2-fold to 3.9-fold) in CLL cybrid cells. Some of the negative effects of chemotherapy include an increase in pro-inflammatory cytokines [45,46], which can contribute to cancer-related fatigue and pro-inflammatory cytokines that play a pivotal role in chemotherapy-related side effects [47]. Many chemotherapeutics, such as cisplatin, etoposide, ibrutinib, paclitaxel, topotecan, and vinblastine, cause cell death by inducing DNA damage, which causes nuclear and mitochondrial DNA leakage into the cytosol and activates cGAS-STING signaling, which is part of innate immunity [48,49].…”

Section: Discussionmentioning

confidence: 99%

Using Human ‘Personalized’ Cybrids to Identify Drugs/Agents That Can Regulate Chronic Lymphoblastic Leukemia Mitochondrial Dysfunction

Singh

Atilano

Chwa

et al. 2023

IJMS

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This study uses personalized chronic lymphoblastic leukemia (CLL) cybrid cells to test various drugs/agents designed to improve mitochondrial function and cell longevity. Age-matched control (NL) and CLL cybrids were created. The NL and CLL cybrids were treated with ibrutinib (Ibr-10 μM), mitochondrial-targeted nutraceuticals such as alpha lipoic acid (ALA-1 mM), amla (Aml-300 μg), melatonin (Mel-1 mM), resveratrol (Res-100 μM) alone, or a combination of ibrutinib with nutraceuticals (Ibr + ALA, Ibr + Aml, Ibr + Mel, or Ibr + Res) for 48 h. MTT (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazoliumbromide), H2DCFDA(2′,7′ Dichlorodihydrofluorescein diacetate), and JC1 assays were used to measure the cellular metabolism, intracellular ROS levels, and mitochondrial membrane potential (∆ψm), respectively. The expression levels of genes associated with antioxidant enzymes (SOD2, GPX3, and NOX4), apoptosis (BAX and CASP3), and inflammation (IL6, IL-1β, TNFα, and TGFβ) were measured using quantitative real-time PCR (qRT-PCR). CLL cybrids treated with Ibr + ALA, Ibr + Aml, Ibr + Mel, and Ibr + Res had (a) reduced cell survivability, (b) increased ROS production, (c) increased ∆ψm levels, (d) decreased antioxidant gene expression levels, and (e) increased apoptotic and inflammatory genes in CLL cybrids when compared with ibrutinib-alone-treated CLL cybrids. Our findings show that the addition of nutraceuticals makes the CLL cybrids more pro-apoptotic with decreased cell survival compared with CLL cybrids exposed to ibrutinib alone.

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Section: Discussionmentioning

confidence: 99%

Using Human ‘Personalized’ Cybrids to Identify Drugs/Agents That Can Regulate Chronic Lymphoblastic Leukemia Mitochondrial Dysfunction

Singh

Atilano

Chwa

et al. 2023

IJMS

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“…Researchers assert that most patients with CRF will benefit from a nonpharmacological intervention during the treatment (McGREGOR;ANTONI, 2009;CHANG et al, 2013;RENNER;. In addition, the CRF symptom has progressively been Introduction highlighted for its direct relation with the use of more aggressive protocols and combined treatments that inevitably enhance toxic effects, exacerbating the cancer symptom clusters.…”

Section: Cancer-related Fatiguementioning

confidence: 99%

Neuroimmunoendocrine trajectories and the response to stress and fatigue in pediatric cancer patients under chemotherapy submitted to clown intervention

Junior¹,

Carlos²

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“…A depressão é considerada um fator de risco para a fadiga a longo prazo e vice-versa (NOAL et al, 2011;TRUDEL-FITZGERALD;SAVARD;IVERS, 2013;HAGEN et al, 2016). Assim, esses achados reforçam os desfechos encontrados por outros estudos (ALICJA JERECZEK-FOSSA;MARSIGLIA;ORECCHIA, 2002;NOAL et al, 2011;TAUNK et al, 2011;SANTOS et al, 2013;SALIGAN et al, 2015b;RENNER;SALIGAN, 2016a), mostrando que a fadiga é um dos sintomas mais frequentes durante a RT e está altamente vinculada ao estado psicológico do ser humano.…”

Section: Tipo De Estudounclassified

Fadiga e depressão em mulheres com câncer de mama tratadas com radioterapia

Gonzaga¹

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AGRADECIMENTOS À Deus, pela força vital que me concede todos os dias e que me alicerça nessa missão, o seu amor me ajuda a superar os todos os obstáculos que enfrentei e tenho enfrentado no decorrer da minha existência. À minha família, minha base, em especial a minha mãe Ana Paula e a meu irmão Melk, pelo amor incondicional e por estarem sempre ao meu lado, me incentivando e sempre acreditando em mim, em momentos até que nem eu mesmo acreditava que era possível e fizeram dos meus sonhos, os nossos sonhos, amo vocês! Ao meu marido, companheiro e melhor amigo Júnior, pelo amor, paciência, incentivo, que apostou nesse sonho junto comigo e me deu apoio incondicional. Obrigada meu amor por estar junto comigo, amo você! Às minhas amigas Bruna Lenhani e Pabliane Marinho, apaixonadas assim como eu pela área do cuidado oncológico, pela amizade e suporte na vida acadêmica e pessoal. Ao meu filho de quatro patas, Kalel, por compartilhar comigo sua energia de amor.

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Understanding cancer-related fatigue: advancing the science

Cited by 3 publications

References 20 publications

Using Human ‘Personalized’ Cybrids to Identify Drugs/Agents That Can Regulate Chronic Lymphoblastic Leukemia Mitochondrial Dysfunction

Using Human ‘Personalized’ Cybrids to Identify Drugs/Agents That Can Regulate Chronic Lymphoblastic Leukemia Mitochondrial Dysfunction

Neuroimmunoendocrine trajectories and the response to stress and fatigue in pediatric cancer patients under chemotherapy submitted to clown intervention

Fadiga e depressão em mulheres com câncer de mama tratadas com radioterapia

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