Understanding COVID-19 vaccine uptake during pregnancy: ‘Hesitance’, knowledge, and evidence-based decision-making

Simmons, Leigh Ann; Whipps, Mackenzie D M; Phipps, Jennifer E.; Satish, Nikita S; Swamy, Geeta K.

doi:10.1016/j.vaccine.2022.03.044

Cited by 36 publications

(35 citation statements)

References 15 publications

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“…This frequency is lower compared to the values of 84.1% ( 20 ) and of 80.7% ( 19 ) observed by some of us in the same geographic area among different groups of individuals. However, the proportion was considerably higher than the values reported in several other studies among pregnant women: 13.8% in Germany ( 31 ), 16.7% in Ukraine ( 41 ), 29.5% in France ( 38 ), 29.7% in Switzerland ( 42 ), 37% in Turkey ( 43 ), 43% in the United States ( 11 ), and 60.8% in Thailand ( 44 ). Moreover, the observed finding is consistent with those found in Czechia and in China with respectively, 76.6% ( 45 ) and 77.4% ( 46 ) of pregnant populations willing to receive the vaccine.…”

Section: Discussioncontrasting

confidence: 59%

“…Although pregnant women, especially those with comorbidities, compared to non-pregnant with COVID-19, are at increased risk of hospital admission, critical care, and invasive ventilation ( 6 , 7 ), yet, COVID-19 vaccine uptake is very low among this group ( 8 – 10 ). A few recent studies have identified a number of individual profiles who would either be hesitant to receive the vaccine or refuse it despite the severity of the disease ( 11 – 14 ). However, to date the hesitancy and the intention about vaccination against SARS-CoV-2 of pregnant women is scarcely reported in Italy ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

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COVID-19 vaccination hesitancy and willingness among pregnant women in Italy

Giudice¹,

Folcarelli²,

Napoli³

et al. 2022

Front. Public Health

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BackgroundPregnant women, especially those with comorbidities, compared to those non-pregnant, have higher risk of developing a severe form of COVID-19. However, COVID-19 vaccine uptake is very low among them.MethodsAn anonymous questionnaire was administered to randomly selected women 18 years of age that were currently pregnant or had just given birth between September 2021 and May 2022 in the geographic area of Naples. Vaccine hesitancy was assessed using the vaccine hesitancy scale (VHS).ResultsA total of 385 women participated. Women who had not been infected by SARS-CoV-2 and who needed information about vaccination against COVID-19 had a higher perceived risk of being infected with SARS-CoV-2. More than half (54.3%) of the women were very afraid of the potential side effects of the COVID-19 vaccination on the fetus. There was higher concern of the side effects of the vaccine on the fetus among those who did not have a graduate degree, those with high-risk pregnancy, those who had not been infected by SARS-CoV-2, those who were more concerned that they could be infected by SARS-CoV-2, those who did not know that this vaccination was recommended for them, and those trusting mass media/internet/social networks for information. Only 21.3% were vaccinated when pregnant, mostly women with a university degree, those who had been infected by SARS-CoV-2 before pregnancy, those who did not need information, and those who acquired information about the vaccination from gynecologists. Almost three-quarters (71.9%) were willing to receive the vaccination and those more likely were those with a university degree, those who have had at least one relative/cohabitant partner/friend who had been infected by SARS-CoV-2, those who were more concerned that they could be infected by SARS-CoV-2, and those who were not extremely concerned of the side effects of the vaccine on the fetus. A total of 86.4% were highly hesitant. Highly hesitant were respondents who did not get a graduate degree, those less concerned that they could be infected by SARS-CoV-2, and those trusting mass media/internet/social networks for information.ConclusionPublic health efforts and education campaigns for pregnant women are needed for changing their perception patterns and for supporting gynecologists in promoting the uptake of this vaccination.

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Section: Discussioncontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

COVID-19 vaccination hesitancy and willingness among pregnant women in Italy

Giudice¹,

Folcarelli²,

Napoli³

et al. 2022

Front. Public Health

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show abstract

“…If pregnant women with a history of complications can easily consult a health care provider (Rasmussen and Jamieson, 2021). The results of this study are in line with Simmons et al (2022), most pregnant women have doubts and do not want to be vaccinated during pregnancy because they have less knowledge about vaccination. Pregnant women who have good knowledge are willing to be vaccinated during pregnancy.…”

Section: Univariate Analysissupporting

confidence: 73%

Factors Affecting Willingness to Vaccinate COVID-19 in Pregnant Women in Manggarai Regency, East Nusa Tenggara, Indonesia

Halu¹,

Dafiq²,

Banul³

et al. 2022

J Matern Child Health

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Background:The COVID-19 vaccination has been recommended by WHO and the Ministry of Health of the Republic of Indonesia. Vaccination is carried out by pregnant women starting from the age of 13 weeks. Vaccines are expected to reduce the risk of pregnant women exposed to COVID-19. However, participation in receiving the COVID-19 vaccine in Manggarai Regency is still low. The purpose of this study was to analyze the factors that influence the willingness to vaccinate against COVID-19 in pregnant women in Manggarai Regency Subjects and Method: This was an analytic observational study with a cross-sectional design approach. This study was conducted in Manggarai Regency, East Nusa Tenggara, from January to May 2022. The sample in this study was 65 pregnant women who had never been vaccinated against COVID-19 with purposive sampling technique. The dependent variable in this study is the willingness of the vaccine. The independent variables are knowledge about COVID-19, knowledge about COVID-19 vaccination, belief, safety, effectiveness and side effects of COVID-19. Data collection using questionnaires and data processing using logistic regression analysis Results: Vaccination willingness was strongly influenced by mother's knowledge about COVID-19 in pregnancy (b=0.046; 95% CI= 0.003 to 0.73; p= 0.031), belief in the COVID-19 vaccine (b= 0.044; CI 95%= 0.003 to 0.757; p= 0.169), vaccination safety (b= 0.048; 95% CI= 0.004 to 0.639; p= 0.022). there was no significant effect, namely knowledge of vaccines (b= 0.195; 95% CI = 0.019 to 2.007; p=0.169) and vaccine effectiveness (b= 0.470; 95% CI= 0.048 to 0.4578; p=0.516). Conclusion:Vaccination willingness was strongly influenced by mother's knowledge about COVID-19 in pregnancy, belief in the COVID-19 vaccine and vaccination safety.

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“…Vaccine hesitancy in the pregnant population was high in the months leading up to and following the release of COVID-19 vaccines with 22.6-86.2% of expectant mothers expressing hesitancy or refusal towards COVID-19 vaccination ( Table 3 ). [61] , [62] , [63] , [64] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] Vaccine hesitancy has also been reported to be higher in pregnant people than non-pregnant women of reproductive age. [82] This hesitancy is understandable given the lack of safety and efficacy data and mixed messaging from health agencies during the first few months of COVID-19 vaccines becoming available.…”

Section: Covid-19 Vaccination and Pregnancymentioning

confidence: 99%

“… [87] , [88] Acceptance of the influenza vaccine and other routine vaccines is positively associated with COVID-19 vaccine acceptance, which suggests that there is a broader and deeper issue of vaccine hesitancy in pregnant people. [41] , [61] , [62] , [64] , [72] , [77] , [79] , [89] Consistently the most common concern amongst pregnant people that were vaccine hesitant was the vaccine potentially causing harmful side effects to their developing baby and another common concern was the lack of safety and efficacy data of the COVID-19 vaccine during pregnancy. [61] , [62] , [63] , [64] , [73] , [74] , [77] , [78] , [80] , [84] , [85] , [86] Despite this, pregnant people report lower rates of common side effects after both first and second doses of COVID-19 vaccines compared to matched non-pregnant female controls.…”

Section: Covid-19 Vaccination and Pregnancymentioning

confidence: 99%