Agronomic treatments and environmental conditions of cultivation affect the nutritional value and technological quality of durum-wheat-based products. The aim of this study was to determine the effect of 18 agronomic treatments that differed in nitrogen rate, sowing density, and growth regulator application on variability in the quality and milling parameters of durum wheat grain, and the interrelationships between these parameters. The study demonstrated that the investigated parameters were modified by the agronomic treatments. However, environmental variance resulting from differences in soil characteristics and climatic conditions dominated in most cases (44–93%). The percentage of variance induced by differences between treatments in total variance was distinctly higher only in the case of the gluten index (59%). The treatments without nitrogen fertilization and with or without the application of the growth regulator, and the treatments with the application of the growth regulator and the nitrogen rate of 120 kg N ha−1, discriminated between the milling parameters associated with sifting (bran, type 1 semolina) and grading of milling products (flour, type 2 semolina, and type 3 semolina), respectively.