Background: Beautifully and colorfully dyed batik cloth is an Indonesian cultural heritage. Batik production exposes workers and the environment to various physical and chemical hazards. This interdisciplinary study aimed to assess the environmental and health parameters of batik workers, and apply environmental and health interventions to achieve environmentally friendly batik production with no human hazards.Methods: To assess the environmental pollutants, the wastewater quality parameters were measured. Air pollutant assessment was done using a low volume sampler. Liver, kidney function and blood chromium were compared between batik workers and healthy controls. Health interventions were done to choose the best gloves for the batik workers followed with assessing convenience level of selected gloves and identifying obstacles that prevent them from using gloves properly. The effectiveness of nerve gliding and wrist exercises in improving carpal tunnel syndrome clinical symptoms were evaluated. Environmental interventions were done by developing wastewater treatment technology using modified electrochemical systems. To assess the sustainability of the “Healthy Batik Village”, we analyzed batik owners’ and workers’ commitment using multi-dimensional scaling methods.Results:The parameters of water pollutants were above the national standard for wastewater, while theair pollutants were still below the standard threshold, withAl, Fe, Cu, and Zn having the highest breathing zone concentrations. There were significant differences (p<0.05) in liver and kidney function levels between batik workers and controls. The modified electrochemical system using graphene electrodes was effective to degrade the dyes used in batik production. Based on the market survey, literature study and comfort assessment, neoprene gloves were chosen as a test glove. Neoprene gloves were considered significantly more convenient compared to polyvinylchloride (PVC) gloves as the workers’ daily gloves (p<0.05).Nerve gliding exercises and wrist splints were effective in causing noticeable carpal tunnel syndrome clinical improvement. Improvements in workers' health, high quality of batik waste treatment, and an ideal management strategy are needed for the sustainability of the "Healthy Batik Village".Conclusion: This study showed there were occupational and environmental hazards exposed to the workers. The health, environmental, and social interventions executed are part of the implementation research to establish the “Healthy Batik Village”.