The projected monsoon hydrological sensitivity, namely, the precipitation change rate per kelvin of global warming, shows substantial intermodel spread among 40 Coupled Model Intercomparison Project phase 5 models. The hydrological sensitivity of the Northern Hemisphere summer monsoon is negatively correlated with that of the Southern Hemisphere summer monsoon. The intermodel spread of the Northern Hemisphere summer monsoon hydrological sensitivity is mainly attributed to the projected interhemispheric temperature gradients and the associated low-level cross-equatorial flows. The intermodel spread of the Afro-Asia summer monsoon sensitivity is rooted in the projected continent-ocean thermal gradients, while the spread of the North American monsoon sensitivity is related to the projected sea surface temperature pattern in the tropical eastern Pacific and Atlantic. These findings suggest that further constraining monsoon hydrological sensitivity requires a better projection of the warming rate between the Northern and Southern Hemispheres and between the land and ocean, and the sea surface warming pattern in the tropical eastern Pacific and Atlantic. Plain Language Summary Global monsoon precipitation has far-reaching impacts on agriculture planning and social-economic sustainable development. Previous studies suggested that the increasing of global monsoon precipitation is sensitive to global warming rate, but the precipitation sensitivities, i.e., the precipitation change rate per kelvin of global warming, are also different among state-of-the-art coupled models. The causes of uncertainty in the monsoon precipitation sensitivity and the associated dominant physical mechanism remain elusive. Based on 40 state-of-the-art coupled climate models, we reveal that the greenhouse gas-induced interhemispheric temperature gradient causes the uncertainty of global monsoon precipitation sensitivity by changing the strengths of monsoon circulation and Hadley circulation and altering the Intertropical Convergence Zone position. Our results highlight the importance of a reliable projection of interhemispheric differential warming to the future change of global monsoon precipitation.