Understanding juvenile myoclonic epilepsy: Contributions from neuroimaging

Anderson, Joseph; Hamandi, Khalid

doi:10.1016/j.eplepsyres.2011.03.008

Cited by 51 publications

(41 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, a recent study found a reduction in GM volume in the supplementary motor area and the posterior cingulate cortex [4]. These discrepant results may be attributed to a small sample size, phenotypic heterogeneity within the sample, or the trait of inhomogeneous cortical folding, or opposing gyri in JME patients [24]. Therefore, in this study, an advanced method was used to measure the thickness of the cortical surfaces in order to differentiate between the cortices of opposing sulcal walls within the same sulcal bed, and this enabled a more precise measurement of deep sulci as well as a better analysis of the morphology of the cortical sheet [14].…”

Section: Cortical Gray Matter Abnormalities In Jme Patientsmentioning

confidence: 88%

Extrafrontal structural changes in juvenile myoclonic epilepsy: A topographic analysis of combined structural and microstructural brain imaging

Kim

Lim

Kim

et al. 2015

Seizure

View full text Add to dashboard Cite

In addition to structural changes in the thalamofrontal system, there was a conspicuous alteration of WM diffusivity in widespread extra-frontal areas and an associated decreased GM thickness in temporoparietal regions, including a significant reduction of hippocampal volume. These findings suggest that the pathophysiology of JME may be not confined to the thalamofrontal circuit but may also involve extensive areas of the extra-frontal network which encompasses temporo-parietal regions.

show abstract

Section: Cortical Gray Matter Abnormalities In Jme Patientsmentioning

confidence: 88%

Extrafrontal structural changes in juvenile myoclonic epilepsy: A topographic analysis of combined structural and microstructural brain imaging

Kim

Lim

Kim

et al. 2015

Seizure

View full text Add to dashboard Cite

show abstract

“…As in humans, jerks are bilateral, arrhythmic, at times asymmetric, and predominate upon the upper limbs and trunk (20,21), whereby additional nodding movements of the head were present in some RRs. EEG recordings revealed a pattern found in human JME patients: SW or PSW discharges with a fronto-central accentuation and a normal background activity with an occasional occurrence of focal activity, EEG asymmetries switching sides, and diffuse or intermittent slowing (22,24,25). An important characteristic shared by human JME and generalized myoclonic epilepsy in RRs is the manifestation with photosensitivity, particularly as JME has one of the strongest associations with photosensitivity among all epilepsies (26,27).…”

Section: Discussionmentioning

confidence: 99%

Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1

Wielaender

Sarviaho

James

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The clinical and electroencephalographic features of a canine generalized myoclonic epilepsy with photosensitivity and onset in young Rhodesian Ridgeback dogs (6 wk to 18 mo) are described. A fully penetrant recessive 4-bp deletion was identified in the DIRAS family GTPase 1 (DIRAS1) gene with an altered expression pattern of DIRAS1 protein in the affected brain. This neuronal DIRAS1 gene with a proposed role in cholinergic transmission provides not only a candidate for human myoclonic epilepsy but also insights into the disease etiology, while establishing a spontaneous model for future intervention studies and functional characterization.seizure | juvenile | canine | photosensitivity | Ras

show abstract

“…Conclusions of a literature review of advanced neuroimaging of JME states that, rather than progressing across the whole cortex, it predominantly involves the frontal lobe (Anderson & Hamandi, 2011). Findings from this review have lead some researchers to call for the reclassification of JME, which is the most common generalised epilepsy in children, as a frontal thalamocortical network epilepsy (ibid., p.127).…”

Section: Classificationmentioning

confidence: 99%