Positive psychology is a useful framework to understand Latina/o students' experiences. In the current study, we examined how presence of meaning in life, search for meaning in life, hope, and family importance influenced 128 Latina/o college students' psychological grit. We used the Meaning in Life Questionnaire (MLQ), Subjective Happiness Scale, Hope Scale, Pan-Hispanic Familism Scale, and Short Grit Scale to measure the aforementioned factors. Using multiple regression analysis, findings indicated that hope and search for meaning in life were significant predictors of psychological grit. Higher levels of hope positively predicted psychological grit, while higher levels of search for meaning in life negatively predicted psychological grit. We provide a discussion regarding the importance of these findings as well as recommendations for future research.