Titanium dioxide (TiO
2
) is one of the most widely used materials in resistive switching applications, including random-access memory, neuromorphic computing, biohybrid interfaces, and sensors. Most of these applications are still at an early stage of development and have technological challenges and a lack of fundamental comprehension. Furthermore, the functional memristive properties of TiO
2
thin films are heavily dependent on their processing methods, including the synthesis, fabrication, and post-fabrication treatment. Here, we outline and summarize the key milestone achievements, recent advances, and challenges related to the synthesis, technology, and applications of memristive TiO
2
. Following a brief introduction, we provide an overview of the major areas of application of TiO
2
-based memristive devices and discuss their synthesis, fabrication, and post-fabrication processing, as well as their functional properties.