Understanding regional mechanics of rat myocardia by fitting hyperelatsic models

Ṋemavhola, Fulufhelo; Ngwangwa, Harry; Pandelani, Thanyani; Davies, N.W.; Franz, Thomas

doi:10.21203/rs.3.rs-957393/v1

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…The mechanical material properties of the sheep trachea were observed to be nonlinear anisotropic and hyperelastic material, similar to other biological soft tissues (Grillo, 1989). Biaxial testing is a reliable method utilised in understanding the mechanical behaviour of soft tissues (Nemavhola, 2017b;Nemavhola et al, 2021b;Nemavhola et al, 2021c;Nemavhola et al, 2021d;Ngwangwa et al, 2022). The data presented in this study covers the circumferential and longitudinal directions.…”

Section: Discussionmentioning

confidence: 94%

“…To understand fully the mechanical properties of the soft tissues, it is necessary to understand its mechanical behaviour (Nemavhola et al, 2021a;Nemavhola et al, 2021b;Greaney and Niklason, 2021;. Mechanical properties of soft tissues may be utilised in developing detailed computational models to study mechanisms of diseases (Masithulela, 2015a;Masithulela, 2015b;Masithulela, 2015c;Masithulela, 2016a;Masithulela, 2016b;Sáez and Kuhl, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Experimental analysis and biaxial biomechanical behaviour of ex-vivo sheep trachea

Pandelani,

Ngwangwa,

Nemavhola

2023

Front. Mater.

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Besides surgery, there are currently no other established methods for routine treatment of tracheal pathologies such a tracheal stenosis or tracheal and airway tumors. Even with several attempts to repair the infected trachea with artificial and natural prostheses, there is a need for the fundamental understanding of the tissue’s mechanical behaviour. The purpose of this study was to investigate the mechanical behaviour of the tracheal tissue under biaxial tensile loading. Furthermore, the study examines the material properties of the tissue through a study of the model parameters for six constitutive models. Materials and methods: The fourteen (n = 14) specimens of sheep trachea (Vleis Merino) measured to be ∼30 × 20 mm where only the effective area of ∼25 × 16 mm was subjected to engineering strain. In this study, we assume that the tracheal tissue is anisotropic and incom-pressible, therefore we apply and study the material parameters from six different constitutive material models. Results: The results show that the tracheal tissue is twice as stiff along the circumferential direction as it is along the longitudinal direction. It is also observed that the material properties are different (non-homogeneous) along the trachea. Conclusion: The findings of this study will benefit computational models for the study of tracheal diseases or injuries. Furthermore, these findings will assist in the development of regenerative medicine for different tracheal pathologies and in the bioengineering of replacement tissue in cases of damage.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Experimental analysis and biaxial biomechanical behaviour of ex-vivo sheep trachea

Pandelani,

Ngwangwa,

Nemavhola

2023

Front. Mater.

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“…The mechanical material properties of the sheep trachea were observed to be nonlinear anisotropic and hyperelastic material, similar to other biological soft tissues [49]. Biaxial testing is a reliable method utilised in understanding the mechanical behaviour of soft tissues [12,20,37,[50][51][52]. The data presented in this study covers the circumferential and longitudinal direction.…”

Section: Discussionmentioning

confidence: 99%

Experimental analysis and biaxial biomechanical behaviour of ex-vivo sheep trachea

Ṋemavhola¹,

Ngwangwa²,

Pandelani

2021

Preprint

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PurposeThe purpose of this study is to investigate the mechanical behaviour of the tracheal tissue under biaxial tensile loading. Furthermore, the study examines the material properties of the tissue through a study of the model parameters for six constitutive models.Materials and methodsThe fourteen (n = 13) trachea sheep (Vleis Merino) pieces of tissues measured to be ~ 30 × 20 mm where only the effective area subjected to engineering strain was ~ 25 × 16 mm. In this study, we assume that the tracheal tissue is anisotropic and incompressible, therefore we apply and study the material parameters from six models namely the Fung, Choi-Vito, Holzapfel (2000), Holzapfel (2005), Polynomial (Anisotropic) and Four-Fiber Family models.ResultsThe results show that the trachea tissue is twice as stiff along the circumferential direction as it is along the longitudinal direction. It is also observed that the material properties are different (non-homogeneous) along the trachea.ConclusionsThe findings of this study will benefit computational models for the study of tracheal diseases or injuries. Furthermore, these findings will assist in the development of regenerative medicine for different tracheal pathologies and in the bioengineering of replacement tissue in cases of damage.

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“…Biaxial tensile testing has been utilised in understanding the mechanical properties of soft tissues. Additionally, hyperelastic constitutive models have also been presented by fitting the constitutive models of the various soft tissues including heart myocardium [56][57][58] and omasum [59].…”

Section: Discussionmentioning

confidence: 99%

Biaxial estimation of biomechanical constitutive parameters of passive porcine sclera soft tissue

Ndlovu¹,

Desai²,

Pandelani³

et al. 2021

Preprint

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This study assesses the modelling capabilities of four constitutive hyperplastic material models to fit the experimental data of the porcine sclera soft tissue. It further estimates the material parameters and discusses their applicability to a finite element model by examining the statistical dispersion measured through the standard deviation. Fifteen sclera tissues were harvested from porcine’ slaughtered at an abattoir and were subjected to equi-biaxial testing. The results show that all the four material models yielded very good correlations at correlations above 96 %. The polynomial (anisotropic) model gave the best correlation of 98 %. However, the estimated material parameters varied widely from one test to another such that there would be needed to normalise the test data to avoid long optimisation processes after applying the average material parameters to finite element models. However, for application of the estimated material parameters to finite element models, there would be needed to consider normalising the test data to reduce the search region for the optimisation algorithms. Although the polynomial (anisotropic) model yielded the best correlation, it was found that the Choi-Vito had the least variation in the estimated material parameters thereby making it an easier option for application of its material parameters to a finite element model and also requiring minimum effort in the optimisation procedure. For the porcine sclera tissue, it was found that the anisotropy more influenced by the fiber-related properties than the background material matrix related properties.

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Understanding regional mechanics of rat myocardia by fitting hyperelatsic models

Cited by 5 publications

References 34 publications

Experimental analysis and biaxial biomechanical behaviour of ex-vivo sheep trachea

Experimental analysis and biaxial biomechanical behaviour of ex-vivo sheep trachea

Experimental analysis and biaxial biomechanical behaviour of ex-vivo sheep trachea

Biaxial estimation of biomechanical constitutive parameters of passive porcine sclera soft tissue

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