Understanding small biomolecule‐biomaterial interactions: A review of fundamental theoretical and experimental approaches for biomolecule interactions with inorganic surfaces

Abstract

Interactions between biomolecules and inorganic surfaces play an important role in natural environments and in industry, including a wide variety of conditions: marine environment, ship hulls (fouling), water treatment, heat exchange, membrane separation, soils, mineral particles at the earth's surface, hospitals (hygiene), art and buildings (degradation and biocorrosion), paper industry (fouling) and more. To better control the first steps leading to adsorption of a biomolecule on an inorganic surface, it is mandatory to understand the adsorption mechanisms of biomolecules of several sizes at the atomic scale, that is, the nature of the chemical interaction between the biomolecule and the surface and the resulting biomolecule conformations once adsorbed at the surface. This remains a challenging and unsolved problem. Here, we review the state of art in experimental and theoretical approaches. We focus on metallic biomaterial surfaces such as TiO(2) and stainless steel, mentioning some remarkable results on hydroxyapatite. Experimental techniques include atomic force microscopy, surface plasmon resonance, quartz crystal microbalance, X-ray photoelectron spectroscopy, fluorescence microscopy, polarization modulation infrared reflection absorption spectroscopy, sum frequency generation and time of flight secondary ion mass spectroscopy. Theoretical models range from detailed quantum mechanical representations to classical forcefield-based approaches.

Modeling and simulation of protein–surface interactions: achievements and challenges

“…Several of these provide a general overview of the adsorption of proteins at solid surfaces (Cohavi et al 2010;Costa et al 2013;Horbett & Brash, 1995;Rabe et al 2011;Qu et al 2013), whereas others focus on more specific aspects such as the determination of the adsorption kinetics of protein-surface binding by weakly bound mobile precursor states (Garland et al 2012), and adsorption on various different surface types, such as metallic surfaces (Tomba et al 2009;Vallee et al 2010), polymer surfaces (Hahm, 2014;Wei et al 2014) and protein repellent surfaces (Szott & Horbett, 2011). The physicochemical properties of nanomaterials, and their applications in medicine, biology and biotechnology, have also been reviewed in several papers (see, e.g.…”

Aqueous Peptide–TiO2 Interfaces: Isoenergetic Binding via Either Entropically or Enthalpically Driven Mechanisms

“…5,17 Therefore, the investigation of entire peptide chains in contact with inorganic surfaces is a critical component in advancing our understanding. 26 The tripeptide motif RGD and its interaction with titania surfaces has been of particular interest, [27][28][29][30][31][32][33] while others have sought to isolate and identify TiO2-binding peptides using biocombinatorial techniques to gain a deeper understanding of which peptide characteristics can confer strong titania-binding affinity. 32,[34][35][36][37] A crucial next step in advancing our understanding is the careful characterization of the adsorption of materials-binding peptides at aqueous titania interfaces.…”

Gamma Globulins Adsorption on Carbofunctional Polysiloxane Microspheres

“…Adsorption of proteins on these surfaces occurs instantly whenever silicones are exposed to biological medium [1,2]. This phenomenon is a very common one and has a great impact on biomedical and biotechnical applications of silicone materials [2][3][4].…”

“…This phenomenon is a very common one and has a great impact on biomedical and biotechnical applications of silicone materials [2][3][4]. Many undesired events such as blood coagulation, thrombosis, immune reactions leading to diseases are caused by protein adsorption [2,5]. On the other hand, the protein adsorption is used to bioactivate synthetic materials.…”

“…Adsorption of proteins on these surfaces occurs instantly whenever silicones are exposed to biological medium [1,2]. This phenomenon is a very common one and has a great impact on biomedical and biotechnical applications of silicone materials [2][3][4]. Many undesired events such as blood coagulation, thrombosis, immune reactions leading to diseases are caused by protein adsorption [2,5].…”