Understanding the causes of obesity in children with trisomy 21: hyperphagia vs physical inactivity

Foerste, T; Sabin, Matthew A.; Reid, Susan M; Reddihough, Dinah

doi:10.1111/jir.12259

Cited by 35 publications

(34 citation statements)

References 32 publications

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“…Obesity itself or its underlying causes appear to contribute to both reduced quality of life (QOL) and high medical complexity especially in the presence of sleep apnea, hepatobiliary disease, musculoskeletal degeneration, cardiopulmonary disease, metabolic disturbance, eating disorders, mood disorders, and reduced physical activity. Some of these relationships are beginning to be explored in youth and adults with DS but their potential interactions require a better understanding (de Winter et al, ; Foerste, Sabin, Reid, & Reddihough, ; Galli, Cimolin, Rigoldi, Condoluci, & Albertini, ; Ordonez et al, ; Ordonez, Rosety, & Rosety‐Rodriguez, ; Real de Asua, Parra, Costa, Moldenhauer, & Suarez, , ; Tenenbaum et al, ; Wee et al, ).…”

Section: Resultsmentioning

confidence: 99%

Co‐occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines

Capone

Chicoine

Bulova

et al. 2017

American J of Med Genetics Pt A

137

136

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Adults with Down syndrome (DS) represent a unique population who are in need of clinical guidelines to address their medical care. The United States Preventive Service Task Force (USPSTF) has developed criteria for prioritizing conditions of public health importance with the potential for providing screening recommendations to improve clinical care. The quality of existing evidence needed to inform clinical guidelines has not been previously reviewed. Using the National Library of Medicine (NLM) database PubMed, we first identified 18 peer reviewed articles that addressed co-occurring medical conditions in adults with DS. Those conditions discussed in over half of the articles were prioritized for further review. Second, we performed detailed literature searches on these specific conditions. To inform the search strategy and review process a series of key questions were formulated a priori. The quality of available evidence was then graded and knowledge gaps were identified. The number of participating adults and the design of clinical studies varied by condition and were often inadequate for answering all of our key questions. We provide data on thyroid disease, cervical spine disease, hearing impairment, overweight-obesity, sleep apnea, congenital heart disease, and osteopenia-osteoporosis. Minimal evidence demonstrates massive gaps in our clinical knowledge that compromises clinical decision-making and management of these medically complex individuals. The development of evidence-based clinical guidance will require an expanded clinical knowledge-base in order to move forward.

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Section: Resultsmentioning

confidence: 99%

Co‐occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines

Capone

Chicoine

Bulova

et al. 2017

American J of Med Genetics Pt A

137

136

View full text Add to dashboard Cite

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“…To achieve success in its treatment patient individualization is needed. Proper exercise and nutrition‐based interventions are the treatment mainstain as for non‐DS patients (Foerste, Sabin, Reid, & Reddihough, ).…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal disorders in Down syndrome

Bermudez

Oliveira

Cat

et al. 2019

American J of Med Genetics Pt A

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Down syndrome is the most common human chromosomal disorder. Among clinical findings, one constant concern is the high prevalence of gastrointestinal system alterations. The aim of this study was to determine the prevalence of gastrointestinal disorders at a Down syndrome outpatient clinic during a 10-year follow-up period. Data from medical files were retrospectively reviewed from 1,207 patients. Gastrointestinal changes occurred in 612 (50.7%). The most prevalent disorder was chronic intestinal constipation. Intestinal parasite occurred in 22% (mainly giardiasis), gastroesophageal reflux disease in 14%, digestive tract malformations occurred in 5%: 13 cases of duodenal atresia, 8 of imperforate anus, 4 annular pancreases, 2 congenital megacolon, 2 esophageal atresias, 2 esophageal compression by anomalous subclavian and 1 case of duodenal membrane. We had 38/1,207 (3.1%) patients with difficulty in sucking and only three with dysphagia that resolved before the second year of life. Peptic ulcer disease, celiac disease, and biliary lithiasis were less prevalent with 3% each. Awareness of the high prevalence of gastrointestinal disorders promotes outstanding clinical follow-up as well as adequate development and greater quality of life for patients with Down syndrome and their families. K E Y W O R D S congenital malformation, Down syndrome, gastrointestinal diseases

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“…In these patients, there is a strong predisposition to cardiovascular disease, seizures [1], leukemia [2,3], infections with hepatitis B virus (especially within institutionalized men) [4], upper respiratory tract infections [5], Alzheimer's disease [6], obesity [7], thyroid diseases [8], cardiac anomalies [9], and obstructive sleep apnea [10,11]. Disruption of the proteostasis network and accumulation of misfolded proteins occur as a result of an abnormality in the number of chromosome 21 [12].…”

mentioning

confidence: 99%

Dental aspects of children with Down syndrome

Ambarkova¹,

Ivkovska²,

Stavreva³

2017

J Dent Probl Solut

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Understanding the causes of obesity in children with trisomy 21: hyperphagia vs physical inactivity

Abstract: Preoccupation with food and low levels of physical activity may contribute to the development of overweight and obesity in some individuals with trisomy 21. These factors warrant consideration in the clinical context.

Cited by 35 publications

References 32 publications

Co‐occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines

Co‐occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines

Gastrointestinal disorders in Down syndrome

Dental aspects of children with Down syndrome

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