2021
DOI: 10.1016/j.phrs.2021.105508
|View full text |Cite
|
Sign up to set email alerts
|

Understanding the complex pharmacology of cannabidiol: Mounting evidence suggests a common binding site with cholesterol

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
6
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
5
4

Relationship

0
9

Authors

Journals

citations
Cited by 13 publications
(6 citation statements)
references
References 84 publications
0
6
0
Order By: Relevance
“…Cannabinoids also appear to interact with other membrane lipids such as cholesterol to exert their effects ( Martin et al, 2021 ). The presence of cholesterol in phosphatidylcholine bilayers increased THC- phosphatidylcholine complex formation and high cholesterol concentrations were proposed to enhance THC activity in the bilayer membrane ( Bruggemann and Melchior, 1983 ).…”
Section: Discussionmentioning
confidence: 99%
“…Cannabinoids also appear to interact with other membrane lipids such as cholesterol to exert their effects ( Martin et al, 2021 ). The presence of cholesterol in phosphatidylcholine bilayers increased THC- phosphatidylcholine complex formation and high cholesterol concentrations were proposed to enhance THC activity in the bilayer membrane ( Bruggemann and Melchior, 1983 ).…”
Section: Discussionmentioning
confidence: 99%
“…An attractive possibility to explain a large number of CBD molecular targets, including the CB1, CB2, and 5-HT1A receptors, and the FAAH enzyme has been recently put forward by Martin and colleagues. It was suggested that CBD modifies these targets by interacting with a cholesterol site on transmembrane proteins [ 168 ].…”
Section: Potential Use Of Cbd To Attenuate the Stress Responsementioning
confidence: 99%
“…CBDV may also indirectly affect CBR signaling, by inhibiting the cellular uptake of AEA, or by inhibiting diacylglycerol-lipase-α (DAGLα) [72]. In vivo, CBDV also acts as a partial agonist for dopamine D2-like receptors [139].…”
Section: Cannabidiol (Cbd)-type Compoundsmentioning
confidence: 99%