Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

Antó, Josep M.; Pinart, Mariona; Akdis, Muebeccel; Auffray, Charles; Bachert, Claus; Basagaña, Xavier; Carlsen, Kai‐Håkon; Guerra, Stefano; Hertzen, Leena von; Illi, Sabina; Kauffmann, F.; Keil, Thomas; Kiley, James P.; Koppelman, Gerard H.; Lupinek, Christian; Martínez, Fernando D.; Nawijn, Martijn C.; Postma, Dirkje S.; Siroux, Valérie; Smit, Henriëtte A.; Sterk, Peter J.; Sunyer, Jordi; Valenta, Rudolf; Valverde, Sergio; Akdiş, Cezmi A.; Annesi‐Maesano, Isabella; Ballester, Ferrán; Benet, Marta; Cambon‐Thomsen, Anne; Chatzi, Leda; Coquet, Jonathan M.; Demoly, Pascal; Gan, Weiniu; Garcia‐Aymerich, Judith; Gimeno‐Santos, Elena; Guihenneuc‐Jouyaux, Chantal; Haahtela, Tari; Heinrich, Joachim; Herr, Marie; Hohmann, Cynthia; Jacquemin, Bénédicte; Just, Jocelyne; Kerkhof, Marjan; Kogevinas, Manolis; Kowalski, Marek L.; Lambrecht, Bart N.; Lau, Susanne; Maier, Dieter; Momas, Isabelle; Noël, Patricia; Oddie, Sam; Palkonen, Susanna; Pin, Isabelle; Porta, Daniela; Punturieri, Antonello; Rancière, Fanny; Smith, Robert A.; Stanić, Barbara; Stein, Renato T.; Veen, Willem van de; Oosterhout, Antoon J. M. van; Varraso, Raphäelle; Wickman, Magnus; Wijmenga, Cisca; Wright, John; Yaman, Görkem; Zuberbier, Torsten; Bousquet, Jean

doi:10.1016/j.jaci.2012.01.047

Cited by 68 publications

(64 citation statements)

References 131 publications

(126 reference statements)

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“…Not all individuals with genetic predisposition express airway hyper reactivity. Clinical expression in individuals with sucseptible genes might not be apparent unless there is an appropriate environmental exposure such as inhalation of ETS by children of smoking adults or exposure to allergens [10, 12,13].…”

Section: Genetic Mechanismsmentioning

confidence: 99%

Passive smoking interference with wheezing and asthma: short review of current knowledge

Mohammad¹

2015

Pulmonol Respir Res

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In 2006, the US general surgeon reported that exposure to (ETS) in early life is causal for wheezing. Although the role of ETS in asthma onset was still inconclusive. However a report by International Study of Asthma and Allergies in childhood published in 2012 suggested that the relationship is causal. Particles present in ETS are of smaller size (0.1 µm) which allows them to penetrate deeply into the lungs resulting in oxidative stress and the liberation of Oxidative Reactive Substances, which are among the most aggressive mechanisms for airway inflammation. There are susceptibility genes for asthma in predisposed individuals, however clinical expression might not be apparent unless there is appropriate environmental exposure such as inhalation of parental ETS by children or exposure to allergens. This exposure to ETS leads to epigenetic changes. Epigenetic changes are defined as heritable changes that affect gene expression without altering the DNA sequence. ETS seems to influence innate immunity predisposing to Th2-associated respiratory diseases and increasing the risk for IgE-mediated sensitization, which could lead to the inflammatory and structural changes seen in allergic diseases, especially asthma. Exposure to water pipe ETS (locally called Narghile, Shisha, or Hookah) is to be considered especially in the Middle East. We hope the next WHO report would consider the harm of in-home environmental tobacco smoke exposure, and the need to protect the rights of children worldwide.

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Section: Genetic Mechanismsmentioning

confidence: 99%

Passive smoking interference with wheezing and asthma: short review of current knowledge

Mohammad¹

2015

Pulmonol Respir Res

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“…Data analysis, integration and modelling require strict statistical procedures in order to avoid false discoveries [119]. Some of these methods are currently used to assess the mechanisms of the development of allergy (MeDALL [16,120]). Such an approach may be used to model NCDs [121].…”

Section: Systems Biology To Identify Unbiased Novel Biomarkers and Mementioning

confidence: 99%

“…Classical (expert based) and novel phenotypes (obtained by hypothesis free statistical models using latent class and cluster analysis) in existing birth cohorts will be compared [120]. The novel phenotypes will be extensively characterised by running IgE and IgG arrays in 2,000 existing samples of birth cohorts.…”

Section: The Medall Approach For Allergic Diseasesmentioning

confidence: 99%

“…The primary aims of these analyses will be the examination of early childhood predictors for allergy and asthma later in life as well as gender differences in the natural course of the disease. Unsupervised statistical analysis will be carried out to compare novel phenotypes (data-driven) to classical phenotypes (hypothesis-driven) [120]. These cross-sectional and longitudinal studies will make it feasible: • To use a large number of possibilities for experimental studies: epigenetics (DNA samples) [130], expression profiling (mRNA), systems biology, IgE and IgG 4 serology (component resolved diagnosis), serum biomarkers.…”

Section: The Medall Approach For Allergic Diseasesmentioning

confidence: 99%

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Systems Medicine Approaches for the Definition of Complex Phenotypes in Chronic Diseases and Ageing. From Concept to Implementation and Policies

Bousquet¹,

Jørgensen²,

Dauzat³

et al. 2014

CPD

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“…It is therefore possible that allergic sensitization mainly occurs shortly after birth. The precise analysis of the period during which new sensitization occurs is currently one of the research topics of the EU-funded research programme MeDALL (http://medall-fp7.eu/ [115]) in which the development of allergic sensitization against more than 170 micro-arrayed allergen molecules will be analysed in serum samples from several birth cohorts using chip technology. The results of a recent analysis of samples from adult allergic patients and nonallergic subjects over a period of 10 years using chips containing almost 100 different micro-arrayed allergen molecules indicate that de novo allergic sensitization to new allergen molecules in allergic adults does not occur during the natural course of allergy (C. Lupinek, K. Marth, R. Valenta, unpublished observations).…”

Section: Prophylactic Sit Approachesmentioning

confidence: 99%

Allergen‐specific immunotherapy: from therapeutic vaccines to prophylactic approaches

Valenta

Campana

Marth

et al. 2012

Journal of Internal Medicine

101

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Immunoglobulin E-mediated allergies affect more than 25% of the population. Allergen exposure induces a variety of symptoms in allergic patients, which include rhinitis, conjunctivitis, asthma, dermatitis, food allergy and life-threatening systemic anaphylaxis. At present, allergen-specific immunotherapy (SIT), which is based on the administration of the disease-causing allergens, is the only diseasemodifying treatment for allergy. Current therapeutic allergy vaccines are still prepared from relatively poorly defined allergen extracts. However, with the availability of the structures of the most common allergen molecules, it has become possible to produce well-defined recombinant and synthetic allergy vaccines that allow specific targeting of the mechanisms of allergic disease. Here we provide a summary of the development and mechanisms of SIT, and then review new forms of therapeutic vaccines that are based on recombinant and synthetic molecules. Finally, we discuss possible allergen-specific strategies for prevention of allergic disease.

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Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

Cited by 68 publications

References 131 publications

Passive smoking interference with wheezing and asthma: short review of current knowledge

Passive smoking interference with wheezing and asthma: short review of current knowledge

Systems Medicine Approaches for the Definition of Complex Phenotypes in Chronic Diseases and Ageing. From Concept to Implementation and Policies

Allergen‐specific immunotherapy: from therapeutic vaccines to prophylactic approaches

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