Background and Aim: Drug or substance abuse is still a major public health concern all over the world. Globally, the rate of fatal substances or drug overdoses has increased in recent decades, owing primarily to prescription drug overdoses, particularly opioids. The aim of the present study was to determine the frequency of socio-demographic factors and variety of substances used by drug induced psychotic patients in tertiary care hospital. Methodology: This retrospective study was conducted on 86 drug-induced psychotic patients attending the Department of Psychiatry at Khattak Medical Center Peshawar, Khyber Teaching Hospital Peshawar and Divisional Headquarter hospital, Mirpur AJK for duration of six months from January 2020 to June 2020. Patient’s demographic details and diagnosis of psychosis were collected and recorded in semi-structured proforma and ICD-10 DCR criteria respectively. Inclusion and exclusion criteria was followed for all the patients enrolled in this study. Socio-demographic details such as age, gender, identification number, educational status, marital status, occupation, socioeconomic status, and family types were all recorded. Results: Out of 86 patients, male and females were 67 (77.9%) and 19 (22.1%) respectively. The majority of the patients were between the ages of 16 and 26. Single patients outnumbered married patients by 37 (43.0%) and 49 (57%) respectively. According to education, the proportion of patients attending university, higher secondary school, secondary school, primary school, and illiterate was 14 (16.3%), 24 (27.9%), 26 (30.2%), 13 (15.1%), and 9 (10.5%) respectively. Patients were mostly unemployed 41 (47.8%). Regarding social status, the prevalence of higher, middle, and lower class was 12 (14%), 47 (54.7%), and 27 (31.4%) respectively. Among 86 patients, Schizophrenia, ATPD, and Mental and Behavioral Disorders were diagnosed in 40 (46.5%), 28 (32.6%), and 18 (20.9%) respectively. Conclusion: Our study revealed that substance abuse is common among drug-induced psychiatric patients. It was also discovered that unemployment could be one of the causes of substance abuse. Our study found a higher prevalence of schizophrenia. Keywords: Socio-demographic; Substance use; drug induced patients