This study investigated the potential adaptation measures for farmers in the Mwanga and Same Districts of Tanzania and then assessed their positive and negative interactions towards potential contributions to the selected sustainable development goal (SDG) indicators of no poverty and zero hunger. A total of 200 household surveys were conducted, and 36 participants were interviewed as key informants. Moreover, four focus group discussions were conducted to identify potential adaptation strategies in the studied areas. The literature and expert judgement approaches were used to understand and assess the positive and negative interactions between adaptation strategies and the selected indicators of SDGs. A seven-point scale of SDG interactions was used to determine the interactions between identified adaptation strategies and selected SDG indicators. Qualitative data were subjected to content analysis, whereas quantitative data were analyzed through descriptive statistics. The finding revealed that some of the adaptation strategies (i.e., stream bank crop cultivation, valley bottom crop cultivation, and cultivating crops near water sources) considered potential at the household levels and had strong negative interactions on achieving SDG 2.4.1. Further, most farmers hardly employed strategies (i.e., use of extension officers, concrete irrigation channels, crop insurance schemes, and credit schemes) that had strong positive interactions on the selected SDG indicators. Moreover, most of the identified strategies (i.e., early maturity crops, planting drought-resistant crops, use of improved varieties, mixing improved and local varieties, mixing short and long duration varieties, and crop diversification) are enabling strategies (+1), which, despite their importance, may constrain (−1) the income of small-scale farmers, food security, and poverty reduction. The importance of other strategies (i.e., irrigation infrastructures) must be addressed for better yields and positive impacts. Hence, achieving SDGs 1 and 2 in the studied areas will require the integration of different adaptation strategies that complement each other, and not by promoting only some strategies as used or suggested before. For example, the emphasis on using improved varieties and crop diversification should be complemented by access to credit schemes, irrigation infrastructures, crop insurance, and extension services at the village level.