2023
DOI: 10.3390/vetsci10080519
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Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control

Abstract: Bovine colostrum (COL), the first milk secreted by lactating cows postpartum, is a rich source of bioactive compounds that exert a significant role in the survival, growth, and immune development of neonatal calves. This study investigated the immunomodulatory effects of COL on cytokine production in vitro using a Caco-2/THP-1 macrophage co-culture model stimulated with Phorbol 12-myristate 13-acetate (PMA). COL pretreatment significantly reduced IL-6 (241.3 pg/mL) production induced by PMA (p < 0.05), whil… Show more

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Cited by 3 publications
(4 citation statements)
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“…In a study exploring the immunomodulatory properties of BC on cytokine production in vitro and in a novel murine-calf fecal microbiota transplantation model, the inhibition effect on IL-6 output and amplified IL-10 production was recorded. In the presence of S. typhimurium infection, colostrum exhibited reduced gut permeability, a decrease in immune cell penetration, and curtailed IL-6 production [36]. This emphasizes the potential of bovine colostrum in modulating the immune response and its potential therapeutic roles in addressing inflammatory conditions.…”
Section: Bovine Colostrum: a Multifaceted Agent In Gut Health Neuroin...mentioning
confidence: 92%
See 1 more Smart Citation
“…In a study exploring the immunomodulatory properties of BC on cytokine production in vitro and in a novel murine-calf fecal microbiota transplantation model, the inhibition effect on IL-6 output and amplified IL-10 production was recorded. In the presence of S. typhimurium infection, colostrum exhibited reduced gut permeability, a decrease in immune cell penetration, and curtailed IL-6 production [36]. This emphasizes the potential of bovine colostrum in modulating the immune response and its potential therapeutic roles in addressing inflammatory conditions.…”
Section: Bovine Colostrum: a Multifaceted Agent In Gut Health Neuroin...mentioning
confidence: 92%
“…The compromised gut barrier can result in the translocation of bacteria and other antigens into the bloodstream, potentially leading to inflammation. BC might strengthen the gut's defense mechanisms [36][37][38].…”
Section: Bovine-colostrum-mediated Restoration Of Duodenal Tight Junc...mentioning
confidence: 99%
“…Cytokines are essential in the immune response, but some cytokines need tight regulation; otherwise, the inflammatory process can have nefarious effects on the organism. For example, IL-6 plays important roles in inflammatory processes at the intestinal level but can also cause tissue damage, compromise the integrity of the intestinal barrier, and lead to systemic infections when overproduced [205,206]. IL-6 is mediated by the nuclear factor kB (NF-kB), which is involved in the pathogenesis of inflammatory diseases [207].…”
Section: Cytokinesmentioning
confidence: 99%
“…IL-6 is mediated by the nuclear factor kB (NF-kB), which is involved in the pathogenesis of inflammatory diseases [207]. Bovine colostrum was able to reduce NF-kB activation and, consequently, IL-6 production in an in vitro model [206]. In another in vitro model, colostrum inhibited the NF-kB pathway in human colon cancer HT29 cells, protecting against intestinal epithelial cell inflammation [208].…”
Section: Cytokinesmentioning
confidence: 99%