Understanding the RALF family: a tale of many species

Murphy, Evan; Smet, Ive De

doi:10.1016/j.tplants.2014.06.005

Cited by 146 publications

(130 citation statements)

References 56 publications

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“…Scale bars = 2 mm. similarity to already known plant signaling molecules (Jun et al, 2008;Murphy and De Smet, 2014).…”

Section: Tws1 Encodes a Novel Proteinmentioning

confidence: 83%

“…A number of chaperonins, translation initiation factors, ribosomal proteins, hormones, signaling molecules, and animal toxins, to mention a few, are all examples of SPs in multicellular organisms; thus, a great variety of biological processes involve the activity of SPs. In plants, some SPs are known to be involved in cell-to-cell communication (Jun et al, 2008;Murphy and De Smet, 2014;Meng et al, 2010) and regulatory processes (Kurata et al, 2005).…”

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confidence: 99%

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TWS1, a Novel Small Protein, Regulates Various Aspects of Seed and Plant Development

et al. 2016

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Small proteins have long been overlooked due to their poor annotation and the experimental challenges they pose. However, in recent years, their role in various processes has started to emerge, opening new research avenues. Here, we present the isolation and characterization of two allelic mutants, twisted seed1-1 (tws1-1) and tws1-2, which exhibit an array of developmental and biochemical phenotypes in Arabidopsis (Arabidopsis thaliana) seeds. We have identified AT5G01075 as the subtending gene encoding a small protein of 81 amino acids localized in the endoplasmic reticulum. TWS1 is strongly expressed in seeds, where it regulates both embryo development and accumulation of storage compounds. TWS1 loss-of-function seeds exhibit increased starch, sucrose, and protein accumulation at the detriment of fatty acids. TWS1 is also expressed in vegetative and reproductive tissues, where it is responsible for proper epidermal cell morphology and overall plant growth. At the cellular level, TWS1 is responsible for cuticle deposition on epidermal cells and organization of the endomembrane system. Finally, we show that TWS1 is a single-copy gene in Arabidopsis, and it is specifically conserved among angiosperms.Developing seeds are a complex system that integrates processes implicated in the coordinated development of different tissues and the intensive activation of many metabolic pathways aimed at massive accumulation of storage compounds and secondary metabolites. As a result, young seedlings are provided with the energy and the building materials required to restarting the plant life cycle.In oleaginous species, such as Arabidopsis (Arabidopsis thaliana), seeds typically contain 30% to 40% storage lipids and 30% to 40% proteins by weight (Baud et al., 2008).

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“…Scale bars = 2 mm. similarity to already known plant signaling molecules (Jun et al, 2008;Murphy and De Smet, 2014).…”

Section: Tws1 Encodes a Novel Proteinmentioning

confidence: 83%

mentioning

confidence: 99%

TWS1, a Novel Small Protein, Regulates Various Aspects of Seed and Plant Development

et al. 2016

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“…Small, secreted peptides (SSPs) have emerged as critical regulators of a diverse array of growth and developmental processes in plants, including aspects of root growth, nutrient homeostasis, meristem maintenance, stress acclimation, pathogen defense, reproductive development, and symbiotic interactions (Marmiroli and Maestri, 2014;Murphy and De Smet, 2014;Djordjevic et al, 2015;Okamoto et al, 2016;de Bang et al, 2017). The biological roles demonstrated thus far suggest that SSPs hold great potential for improving diverse agronomic traits benefitting agricultural production.…”

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confidence: 99%

Genome-Wide Identification of Medicago Peptides Involved in Macronutrient Responses and Nodulation

et al. 2017

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Growing evidence indicates that small, secreted peptides (SSPs) play critical roles in legume growth and development, yet the annotation of SSP-coding genes is far from complete. Systematic reannotation of the Medicago truncatula genome identified 1,970 homologs of established SSP gene families and an additional 2,455 genes that are potentially novel SSPs, previously unreported in the literature. The expression patterns of known and putative SSP genes based on 144 RNA sequencing data sets covering various stages of macronutrient deficiencies and symbiotic interactions with rhizobia and mycorrhiza were investigated. Focusing on those known or suspected to act via receptor-mediated signaling, 240 nutrient-responsive and 365 nodulation-responsive Signaling-SSPs were identified, greatly expanding the number of SSP gene families potentially involved in acclimation to nutrient deficiencies and nodulation. Synthetic peptide applications were shown to alter root growth and nodulation phenotypes, revealing additional regulators of legume nutrient acquisition. Our results constitute a powerful resource enabling further investigations of specific SSP functions via peptide treatment and reverse genetics.

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“…Additionally, it has been shown that several Cys-rich peptides also have a role in plant development, pollen recognition and guidance, and seed development (Marshall et al, 2011;Qu et al, 2015) (Figure 2). In this section, we highlight some typical representatives of those Cys peptides, but refer to excellent recent reviews for a more complete overview on Cys-rich peptides (Marshall et al, 2011;Beale and Johnson, 2013;Richardson and Torii, 2013;de Souza Cândido et al, 2014;Murphy and De Smet, 2014;Nawrot et al, 2014).…”

Section: Cysteine-rich Peptidesmentioning

confidence: 99%

“…Using a phosphoproteomics approach, FERONIA (FER), a member of the Catharanthus roseus RLK1-LIKE KINASE (Cr-RLK1L) family of receptors, could be identified as a RALF receptor (Haruta et al, 2014); subsequently, a model for the signaling transduction pathway was presented (Wolf and Höfte, 2014). For more information on the RALF peptide family, we refer to a recent review (Murphy and De Smet, 2014).…”

Section: Cysteine-rich Peptidesmentioning

confidence: 99%

The Plant Peptidome: An Expanding Repertoire of Structural Features and Biological Functions

et al. 2015

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Understanding the RALF family: a tale of many species

Cited by 146 publications

References 56 publications

TWS1, a Novel Small Protein, Regulates Various Aspects of Seed and Plant Development

TWS1, a Novel Small Protein, Regulates Various Aspects of Seed and Plant Development

Genome-Wide Identification of Medicago Peptides Involved in Macronutrient Responses and Nodulation

The Plant Peptidome: An Expanding Repertoire of Structural Features and Biological Functions

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