Gas-and-ash explosions at the Santiaguito dome complex, Guatemala, commonly occur through arcuate fractures, following a 5-to 6-min period of inflation observed in long-period seismic signals. Observation of active faults across the dome suggests a strong shear component, but as fault propagation generally proceeds through the coalescence of tensile fractures, we surmise that explosive eruptions require tensile rupture. Here, we assess the effects of temperature and strain rate on fracture propagation and the tensile strength of Santiaguito dome lavas. Indirect tensile tests were conducted on samples with a porosity range of 3-30% and over diametral displacement rates of 0.04, 0.004, and 0.0004 mm/ s. At room temperature, the tensile strength of dome rock is rate independent (within the range tested) and inversely proportional to the porosity of the material. At eruptive temperatures we observe an increasingly ductile response at either higher temperature or lower displacement rate, where ductile deformation is manifest by a reduction in loading rate during constant deformation rate tests, resulting in slow tearing, viscous flow, and pervasive damage. We propose a method to conduct indirect tensile tests under volcanic conditions using a modification of the Brazilian disc testing protocol and use brittleness indices to classify deformation modes across the brittle-ductile transition. We show that a degree of ductile damage is inevitable in the lava core during explosions at the Santiaguito dome complex and discuss how strain leading to rupture controls fracture geometry, which would impact gas pressure release or buildup and regulate explosive activity.Plain Language Summary Using instruments we installed at Santiaguito, an active lava dome complex in Guatemala, we detected repeating cycles of inflation and deflation. The inflation took less time leading up to explosions compared to weak gas puffing, which led us to suspect that lava breaking and flowing might be responsible. To investigate this, we made laboratory tests where we put lava samples under tension, which is the most common way they break. We ran tests where we squeezed lavas at faster and slower rates in a press, and we also heated the lavas to their eruption temperatures-about 800°C-for some tests. Since the lavas contain volcanic glass, in some high temperature tests the glass partially flowed. In other tests the lavas were completely brittle, which means they stored up stress and then broke without flowing. The lava's behavior depends on the temperature and how fast they are squeezed. Finally, we considered how fast dome lavas at Santiaguito would have to be deformed to either break or stay intact during inflation of the dome. This study gives us a better idea of how dome lavas deform and how that affects hazardous activity during eruptions.