Underutilization of gastroprotective drugs in patients receiving non-steroidal anti-inflammatory drugs

Thiéfin, Gérard; Schwalm, M.-S.

doi:10.1016/j.dld.2010.09.009

Cited by 15 publications

(28 citation statements)

References 34 publications

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“…14 According to Thiéfin et al 15 , in France, only half of NSAID users (above 65 years old) receive gastrointestinal protective agents, which is in accordance to this study. 15 According to the data of this study, from 313 older adult patients who are prescribed NSAID only 68 patients (32%) are given gastric drug as a companion of NSAID.…”

Section: Discussionsupporting

confidence: 72%

“…15 According to the data of this study, from 313 older adult patients who are prescribed NSAID only 68 patients (32%) are given gastric drug as a companion of NSAID. From these data, it is concluded that gastric drug used as an adjuvant drug of NSAID in older adult patients is still low, while as noted above, the possibility of adverse effects on gastric increase as well as increase of the age.…”

Section: Discussionmentioning

confidence: 99%

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Analgesic Usage in Elderly at Public Health Center: A study in West Java, Indonesias

Putro¹,

Sastramihardja²,

Dwipa³

2017

amj

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Background: Various analgesics prescriptions for elderly are not appropriate according to the guideline and can cause the increase of side effects such as gastric problems. Puskesmas as a public health center in Indonesia has an important role in anticipating this problem. The objectives of this study was to identify the analgesic usage in elderly patients at the public health center. Methods: This retrospective descriptive study was conducted for 3 months at Tanjungsari public health center, Sumedang, West Java, Indonesia, using total sampling. The data was taken from 417 medical records from 2013. The data taken from medical records were: sex, analgesic drug, diagnosis, and drug for gastric problem. Results: From the collected data, the most analgesics prescribed for the elderly patients was paracetamol, followed by Piroxicam, Mefenamic acid, and Ibuprofen. Not all of the elderly patients who received NSAIDs, were given gastric drug. Conclusions:The most prescribed analgesic drug given to elderly patients at the public health center is paracetamol. [AMJ.2017;4(1):16-9]

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Analgesic Usage in Elderly at Public Health Center: A study in West Java, Indonesias

Putro¹,

Sastramihardja²,

Dwipa³

2017

amj

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“…In Canada, 44% of aspirin users with a history of peptic ulcer complications did not receive concomitant PPI therapy 18. In France, only half of NSAID users above 65 years received gastroprotective agents 19. Our observations provide important evidence to avoid under-utilisation of gastroprotective agents in high-risk patients receiving NSAIDs.…”

Section: Discussionmentioning

confidence: 78%

Long-term peptic ulcer rebleeding risk estimation in patients undergoing haemodialysis: a 10-year nationwide cohort study

Wu¹,

Kuo

et al. 2011

Gut

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“…Lanas et al (2011) reported similar fi ndings in NSAIDs users and low dose ASA users (22). However, some studies failed to demonstrate an association between the number of risk factors for GI bleeding and prescription of gastroprotective medication (24,25).…”

Section: Discussionmentioning

confidence: 49%

“…Although the use of gastroprotective therapy in NSAIDs users was widely described in the literature (21,22,23,24), there are only few studies that assessed the prescription patterns of gastroprotective therapy in patients using antiplatelet agents (23,25,26). For this reason, the aim of our study was to evaluate the use of gastroprotective medication in elderly patients taking antiplatelet drugs in relationship to their GI bleeding risk.…”

mentioning

confidence: 99%

Suboptimal use of gastroprotective medication in elderly antiplatelet users

Slezakova¹,

Varga²,

Murı́n³

et al. 2014

BLL

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Abstract:Background: Use of acetylsalicylic acid (ASA) or thienopyridines in monotherapy or combination of both drugs is associated with increased risk of gastrointestinal (GI) bleeding. The administration of drugs inhibiting gastric acid production represents an effective way to avoid GI disorders associated with antiplatelet therapy. Objectives: The aim of our study was to evaluate the use of gastroprotective medication in elderly antiplatelet users in relation to risk factors for GI bleeding. Methods: Patients (n = 428) aged ≥ 65 years who were prescribed low dose ASA or clopidogrel in monotherapy or combination at hospital discharge were enrolled in the study. Results: Only 39.7 % of patients with 2 or more risk factors for GI bleeding were prescribed gastroprotective medication at hospital discharge. The probability of elderly antiplatelet drug user for prescription of gastroprotective medication was improved with following risk factors: age ≥ 85 years (OR = 2.99); history of peptic ulcer disease/ GI bleeding (OR = 15.79); other GI disorders (OR = 15.48); concomitant therapy with drugs increasing the risk of GI bleeding -systemic corticosteroids (OR = 29.03) and NSAIDs (OR = 4.79). Conclusion: Results of our study indicate the necessity to increase the awareness of GI bleeding risk in longterm antiplatelet users among prescribing physicians (Tab. 3, Ref. 36). Text in PDF www.elis.sk.

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Underutilization of gastroprotective drugs in patients receiving non-steroidal anti-inflammatory drugs

Cited by 15 publications

References 34 publications

Analgesic Usage in Elderly at Public Health Center: A study in West Java, Indonesias

Analgesic Usage in Elderly at Public Health Center: A study in West Java, Indonesias

Long-term peptic ulcer rebleeding risk estimation in patients undergoing haemodialysis: a 10-year nationwide cohort study

Suboptimal use of gastroprotective medication in elderly antiplatelet users

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