Underutilized citrus species: An insight of their nutraceutical potential and importance for the development of functional food

Kumar, Vikas; Kaur, Ramandeep; Aggarwal, Poonam; Singh, Gurvinder

doi:10.1016/j.scienta.2022.110909

Cited by 28 publications

(10 citation statements)

References 138 publications

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“…Eucalyptus leaf residue contains a small amount of flavonoids. Studies indicated that flavonoids in eucalyptus leaves have antibacterial, anti-cardiovascular, anti-inflammatory, analgesic and significant antioxidant properties, which could be developed for new, natural antioxidant-containing functional foods and applied widely in the pharmaceutical field [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Preliminary Study on Total Component Analysis and In Vitro Antitumor Activity of Eucalyptus Leaf Residues

Wu,

Wang,

Cheng

et al. 2024

Molecules

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Eucalyptus globulus is widely introduced and cultivated in Yunnan province. Its foliage is mainly used to extract eucalyptus oil, but the by-product eucalyptus residue has not been fully utilized. Based on the above reasons, in this study, we sought to explore the comprehensive utilization potential of eucalyptus resources. The total composition of eucalyptus residue was analyzed by ultra performance liquid chromatography-time-of-flight mass spectrometry (UPLC-Q/TOF MS), and the active components and nutrient components of eucalyptus leaf residue were determined by chemical methods and liquid phase techniques. Meanwhile, the antitumor activity of triterpenoids in eucalyptus leaves was evaluated by tetramethylazazole blue colorimetric assay (MTT). The results of qualitative analysis indicated that 55 compounds were identified from eucalyptus residue, including 28 phloroglucinols, 17 terpenoids, 3 flavonoids, 5 fatty acids, 1 amino acid and 2 polyphenols. Among them, the pentacyclic triterpenoids, in eucalyptus residue, were mainly oleanane type and urthane type. The results of quantitative determination indicated that the content of triterpenoid compounds was 2.84% in eucalyptus residue, which could be enhanced to 82% by silicone separation. The antitumor activity results showed that triterpenoid compounds have moderate inhibitory effects on human breast cancer cell MDA-MB-231, gastric adenocarcinoma cell SGC-7901 and cervical cancer cell Hela. The half maximal inhibitory concentration (IC50) was 50.67, 43.12 and 42.65 μg/mL, respectively. In this study, the triterpenoids from eucalyptus leaf residues were analyzed to reveal that the triterpenoids from eucalyptus leaf have antitumor effects and have potential to be developed as antitumor drugs.

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Section: Resultsmentioning

confidence: 99%

Preliminary Study on Total Component Analysis and In Vitro Antitumor Activity of Eucalyptus Leaf Residues

Wu,

Wang,

Cheng

et al. 2024

Molecules

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“…These new orange pectins, sustainably sourced using only water and electricity, can be used to produce biocompatible and antimicrobial films similar to what happens with grapefruit and lemon IntegroPectin, having broad-scope antimicrobial properties [ 38 ]. Given the wide-ranging and powerful biological activities of pectin [ 39 ], citrus flavonoids, and terpenes [ 40 ], the application potential of these new orange pectins might range from neuro- and cardiovascular protection to oral hygiene. Forthcoming studies will unveil the first biological properties of these new pectins derived by the most widely harvested citrus fruit.…”

Section: Discussionmentioning

confidence: 99%

Red Orange and Bitter Orange IntegroPectin: Structure and Main Functional Compounds

et al. 2022

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DRIFT, HPLC-MS, and SPME-GC/MS analyses were used to unveil the structure and the main functional compounds of red (blood) orange (Citrus sinensis) and bitter orange (Citrus aurantium). The IntegroPectin samples show evidence that these new citrus pectins are comprised of pectin rich in RG-I hairy regions functionalized with citrus biophenols, chiefly flavonoids and volatile molecules, mostly terpenes. Remarkably, IntegroPectin from the peel of fresh bitter oranges is the first high methoxyl citrus pectin extracted via hydrodynamic cavitation, whereas the red orange IntegroPectin is a low methoxyl pectin. C. aurantium IntegroPectin has a uniquely high concentration of adsorbed flavonoids, especially the flavanone glycosides hesperidin, naringin, and eriocitrin.

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“…35 These pectins can be used to produce biocompatible films that, likewise to what happens with grapefruit and lemon IntegroPectin, might have intrinsic antimicrobial properties due to synergy emerging from the combined action of the citrus flavonoids and terpenes adsorbed at the IntegroPectin surface, and the unique molecular structure of these new pectic biopolymers. 39 Given the broad scope biological activity of pectin, 40 as well as of citrus flavonoids and terpenes, 41 the application potential of these new orange pectins might range from neuro-to cardiovascular protection. Forthcoming studies will unveil the first biological properties of these new pectins derived by the most widely harvested citrus fruit.…”

Section: Discussionmentioning

confidence: 99%

Red Orange and Bitter Orange IntegroPectin: Structure and Main Functional Compounds

Scurria

Sciortino²,

García

et al. 2022

Preprint

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DRIFT, HPLC-MS and SPME-GC/MS analyses used to unveil the structure and the main functional compounds of red (blood) orange (Citrus sinensis) and bitter orange (Citrus aurantium) IntegroPectin show evidence that these new citrus pectins are comprised of pectin rich in RG-I hairy regions functionalized with citrus biophenols, chiefly flavonoids, and volatile molecules, mostly terpenes. Remarkably, IntegroPectin from the peel of fresh bitter oranges is the first high methoxyl citrus pectin isolated so far via hydrodynamic cavitation, whereas red orange IntegroPectin is a low methoxyl pectin. C. aurantium IntegroPectin has a uniquely high concentration of adsorbed flavonoids, especially flavanone glycosides hesperidin, naringin and eriocitrin.

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Underutilized citrus species: An insight of their nutraceutical potential and importance for the development of functional food

Cited by 28 publications

References 138 publications

Preliminary Study on Total Component Analysis and In Vitro Antitumor Activity of Eucalyptus Leaf Residues

Preliminary Study on Total Component Analysis and In Vitro Antitumor Activity of Eucalyptus Leaf Residues

Red Orange and Bitter Orange IntegroPectin: Structure and Main Functional Compounds

Red Orange and Bitter Orange IntegroPectin: Structure and Main Functional Compounds

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