Unexpected Diagnosis of Both Adenocarcinoma of the Colon and Metastatic Lobular Carcinoma of the Breast in the Gastrointestinal Tract

Miller, Tegan; Ross, Carol; Al-Rawi, Haitham; Taylor, Ben; Al-Jafari, Mohammad

doi:10.1155/2013/153180

Cited by 3 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Breast cancer had not been previously diagnosed. The authors point out that this is the only case in the available literature of coexistence of colon adenocarcinoma and metastatic lobular breast cancer in the same part of the colon, where breast cancer had not been diagnosed previously [14]. The authors described the presence of one tumor next to another (coexistence) and did not describe the presence of metastatic deposits of lobular carcinoma of the breast in the primary adenocarcinoma of the colon.…”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Jejunal tumor made of primary gastrointestinal stromal tumor and metastatic breast carcinoma - an extremely rare case

et al. 2017

View full text Add to dashboard Cite

Introduction The occurrence of synchronous or metachronous malignant epithelial and mesenchymal tumors is rare. Infiltrating ductal breast cancer rarely produces metastasis in the gastrointestinal tract, and when it does, it represents a significant differential diagnostic problem. Morphologically, they can mimic primary cancers localized in the gastrointestinal tract or peritoneum. Case outline In this paper, we present a female patient with primary, synchronous bilateral breast cancer, which after five years of follow-up had given metastases to the lungs, bones, peritoneum and mesentery, and in a node localized in the small intestine. The node was composed of two malignant components-a mesenchymal one and an epithelial one. The mesenchymal component had histologic and immunophenotypic characteristics of a gastrointestinal stromal tumor and the epithelial component was morphologically and immunohistochemically identical to the diagnosed primary breast cancer. Because of all this, the nodal tumor mass was interpreted as a primary gastrointestinal stromal tumor of the small intestine, in which the deposit of metastatic ductal breast carcinoma was observed. Conclusion Metastases of breast cancer in organs of the gastrointestinal tract are encountered rarely, mainly in the terminal stage of the disease. In available literature, a case of metastasis of breast cancer (metastasis of malignant epithelial tumors) in gastrointestinal stromal tumor has not been found.

show abstract

Section: Discussionmentioning

confidence: 89%

“…Miller et al [14] described the case of a patient with a synchronously diagnosed adenocarcinoma of the colon and metastatic lobular carcinoma in the colon and small intestine. Colon adenocarcinoma was localized in the sigmoid colon.…”

Section: Discussionmentioning

confidence: 99%

Jejunal tumor made of primary gastrointestinal stromal tumor and metastatic breast carcinoma - an extremely rare case

et al. 2017

View full text Add to dashboard Cite

show abstract

“…GI tract metastases usually occur four to five years after primary breast cancer diagnosis but sometimes 20 or even 30 years later. Occasionally, their presentation is concurrent but, rarely, they may be the first clinical manifestation of breast cancer [ 4 , 19 ]. The rate of GI tract involvement in metastatic breast cancer is around 1% and is found in up to 12% of autopsies [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…The reason for this different metastatic pattern has been suggested to be the loss of E-cadherin [ 18 ]. ILC metastasizes more commonly to the GI tract than NST carcinoma of the breast with an incidence of 4.5% and 0.2%, respectively [ 18 ] and is usually associated with disseminated disease [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…The latter variant shows both intra- and extracellular mucin production, a rare feature among breast carcinomas [ 3 ]. The ILC metastatic pattern is different compared to invasive ductal carcinoma, metastasizing more often to the gastrointestinal (GI) tract, peritoneum, pleura, and ovaries [ 4 - 5 ] whereas invasive carcinoma of no special type (NST) metastasizes more often to the lungs, liver, and brain [ 4 ]. Extrahepatic GI tract metastasis involves more often the stomach and the small intestine and, very rarely, the colon and rectum [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synchronous Colonic Adenocarcinoma and Metastatic Lobular Carcinoma in a Colectomy Specimen: A Rare Finding

Koufopoulos

Goudeli

Pigadioti

et al. 2018

Cureus

View full text Add to dashboard Cite

Invasive lobular carcinoma is the second-most-common subtype of invasive breast carcinoma. Its metastatic pattern is different compared to invasive carcinoma—no special type. It metastasizes more often to the gastrointestinal tract, peritoneum, pleura, and ovaries. The extrahepatic gastrointestinal tract metastases occur mostly in the stomach and small intestine and less often in the colon and rectum.We present a case description of an 87-year-old woman admitted to our hospital with hematochezia, abdominal discomfort, fatigue, and weight loss. A colonoscopy revealed an exophytic tumor of the sigmoid colon. Metastatic disease was not found in imaging studies. A low anterior resection was performed. The pathologic examination revealed a collision tumor consisting of a poorly differentiated adenocarcinoma of the colon and metastatic lobular carcinoma. The diagnosis was challenging due to the lack of a previous history. Also, the diffuse architectural pattern and signet ring cells found may be in primary signet ring carcinoma of the colon as well as in carcinomas from other anatomical sites. Immunohistochemistry was helpful in making the diagnosis. A review of the literature revealed that this is the fourth case of metastatic breast carcinoma coexisting with colonic adenocarcinoma.

show abstract

A rare case of lobular breast cancer metastasizing to large bowel

Yanagisawa

Krishnan²,

Fernandez³

2021

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Unexpected Diagnosis of Both Adenocarcinoma of the Colon and Metastatic Lobular Carcinoma of the Breast in the Gastrointestinal Tract

Cited by 3 publications

References 16 publications

Jejunal tumor made of primary gastrointestinal stromal tumor and metastatic breast carcinoma - an extremely rare case

Jejunal tumor made of primary gastrointestinal stromal tumor and metastatic breast carcinoma - an extremely rare case

Synchronous Colonic Adenocarcinoma and Metastatic Lobular Carcinoma in a Colectomy Specimen: A Rare Finding

A rare case of lobular breast cancer metastasizing to large bowel

Contact Info

Product

Resources

About