Unexpected increased ferritin concentration in patients with anorexia nervosa

Tran, J; Story, Colin; Moore, David; Metz, Michael

doi:10.1177/0004563213490289

Cited by 9 publications

(8 citation statements)

References 10 publications

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“…There was a significant increase in the iron storage ferritin in group 2, we suggested that the higher serum ferritin concentrations represent an increased state of inflammation, as it acts as an acute phase reactant [20]; furthermore, ferritin has non-storage roles within the body, such as protection from oxidative damage [21]. Indeed, its synthesis is increased in response to oxidative stress [22] which was stated to occur in chronic kidney disease [23], and it is, therefore, a non-reliable indicator of iron disturbance [20].…”

Section: Disscussionmentioning

confidence: 84%

Fetuin A effect on iron status and hepcidin level in adenine induced chronic kidney disease male rat model

nouwairy

ali

Ashour³

et al. 2022

Zagazig University Medical Journal

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Background: Chronic kidney disease describes loss of kidney function gradually; it may not become apparent in early stages until chronic kidney disease reaches an advanced stage that lead to accumulation of fluid, electrolytes and wastes and development of anemia Aim of study: The aim of this study was to investigate the possible role of fetuin A in improving anemia resulting from adenine induced chronic kidney disease in male rat. methods: Group A: rats feed normal diet for 21 days. Group B: rats feed normal diet with adenine for 21 days. Group C: rats feed normal diet with adenine for 21 days after that intraperitoneal administration of fetuin A every other day for 2 weeks. Serum samples were assayed for: creatinine, urea, iron , total iron binding capacity, ferritin, tumor necrosis factor, hepcidin. Hemoglobin content, blood indices were determined, and estimated Glomerular filtration rate was measured in addition, histopathology of the kidney was done Results: In group B: there was significant increase in serum creatinine, urea and ferritin decrease in serum iron, total iron binding capacity, hemoglobin content and estimated Glomerular filtration rate and no significant change in blood indices .Regarding inflammatory markers significant increase .Regarding renal histopathology there was moderate tubular necrosis, tubular dilatation, and mononuclear leucocytes infiltration. In group C we observed that fetuin A ameliorated these changes. . Conclusion: Fetuin A improve anemia in chronic renal failure in rat model, may be due to reduction of hepcidin or it is anti-inflammatory and anti fibrotic effect.

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Section: Disscussionmentioning

confidence: 84%

Fetuin A effect on iron status and hepcidin level in adenine induced chronic kidney disease male rat model

nouwairy

ali

Ashour³

et al. 2022

Zagazig University Medical Journal

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“…Elevated ferritin concentrations have previously been reported in AN (8,9,10,11,12,13,14,15,16). Although iron insufficiency from inadequate oral intake is common, iron metabolism is believed to be intact despite both high and low ferritin levels that can occur with AN (14).…”

Section: Discussionmentioning

confidence: 96%

Extreme hyperferritinemia in restrictive type anorexia nervosa

Amanoal

Nielsen

Thomsen

2023

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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Summary Iron metabolism and markers hereof are altered in anorexia nervosa (AN) but far from completely understood. We report a case of extreme hyperferritinemia in a patient with AN and discuss the possible mechanisms and current knowledge about the association between hyperferritinemia and AN. A 20-year-old woman with a history of AN presented with bradycardia, weariness, and malaise in addition to an incidentally very high ferritin level. The symptoms disappeared spontaneously after a short admission. There were no signs suggestive of systemic, hematological, or malignant disease causing the very high concentration of ferritin. Her body weight was in decline, leading up to admission, but did initially increase after discharge accompanied by declining ferritin concentration. However, a clear association between ferritin dynamics and weight changes or physical activity was not identified and neither were other causes of the hyperferritinemia. Around one in four patients with AN have increased ferritin concentrations. Our case represents the highest ferritin concentration reported in a patient with AN without other underlying causes or comorbidities. Learning points Perturbed iron metabolism is frequent in restrictive type anorexia nervosa but incompletely understood. Altered ferritin in anorexia nervosa may be linked to nutritional status.

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“…Although these results are not consensual in the literature, 17 several authors have reported increased ferritin values in AN patients, with a tendency to normalization associated with weight recovery. 15,16,[28][29][30] Ferritin is frequently used to evaluate Iron stores, but may be elevated in situations such as liver damage, neoplasia, infection, and inflammation. Thus, it is difficult to interpret its elevation in AN patients, and, currently, its pathophysiological mechanism is not clear.…”

Section: Discussionmentioning

confidence: 99%

Outpatient Analytic Assessment of Anorexia Nervosa — The Importance of Venous Blood Gases

Pires

Soares²,

Luz³

et al. 2020

Rev. paul. pediatr.

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Objective: To evaluate serum biochemical parameters’ evolution, especially venous blood gas (VBG), in anorexia nervosa (AN), correlating with clinical parameters. Methods: Retrospective study including out-patient AN adolescents, between January 2014 and May 2017. Three evaluations were compared: t1) first consultation; t2) consultation with the lowest body mass index (BMI) z-score and t3) with the highest BMI z-score. Results: A total of 24 adolescents (87.5% females) were included, mean age of presentation of 14.9±1.7 years, onset of symptoms 6.4±3.2 months before the first visit. In t1, BMI z-score of -1.91±1.11 kg/m2 and ideal weight % of 84.3±9.2. Amenorrhea was present in 88%. In t2 the analytical alterations were: altered VBG in 100%, altered ferritin (72% elevated), altered thyroid function (53% with thyroxine decrease), dyslipidemia (31% elevation of high density lipoprotein, 25% hypercholesterolemia), elevation of urea (25%), elevation of alanine aminotransferase (14%), hypoglycemia (14%), anemia (9%). Respiratory acidosis was present in 91% in t1, 100% in t2 and 94% in t3. There was a significant decrease between t2 and t3 in mean pCO2 (57.2 versus 53.6 mmHg; p=0.009) and mean HCO3 (30.0 versus 28.8 mEq/L; p=0.023). Conclusions: Respiratory acidosis and increased ferritin were common in this group. Respiratory acidosis was the most frequent abnormality with significant pCO2 and HCO3 variation in the recovery phase. VBG should be considered in AN evaluation, once it seems to be important in assessing the severity of the disease and its subsequent follow-up.

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Unexpected increased ferritin concentration in patients with anorexia nervosa

Cited by 9 publications

References 10 publications

Fetuin A effect on iron status and hepcidin level in adenine induced chronic kidney disease male rat model

Fetuin A effect on iron status and hepcidin level in adenine induced chronic kidney disease male rat model

Extreme hyperferritinemia in restrictive type anorexia nervosa

Outpatient Analytic Assessment of Anorexia Nervosa — The Importance of Venous Blood Gases

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