Unexpected Reproductive Effect of Prolonged Oral Administration of Silver Nanoparticles in Laboratory Mice

Zinicovscaia, Inga; Инга, Зиньковская; Ivlieva, A. L.; Леонидовна, Ивлиева Александра; Petritskaya, E. N.; Николаевна, Петрицкая Елена; Рогаткин, Д. А.; Алексеевич, Рогаткин Дмитрий

doi:10.33396/1728-0869-2020-10-23-30

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…Presumably, higher silver accumulation in the testes may cause other toxic effects in the reproductive system, which were not considered in the present work, but in [ 11 , 22 , 42 , 43 , 44 ]. Exposure to AgNPs may influence mice fertility [ 45 ]. Also, AgNPs may be transported from the exposed during pregnancy females to the offspring via placental and mammary gland barriers [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Neurotoxicity of Silver Nanoparticles and Non-Linear Development of Adaptive Homeostasis with Age

et al. 2023

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For the first time in the world, the behavioral functions of laboratory mammals exposed to silver nanoparticles were studied with regard to age. Silver nanoparticles coated with polyvinylpyrrolidone with a size of 8.7 nm were used in the present research as a potential xenobiotic. Elder mice adapted to the xenobiotic better than the younger animals. Younger animals demonstrated more drastic anxiety than the elder ones. A hormetic effect of the xenobiotic in elder animals was observed. Thus, it is concluded that adaptive homeostasis non-linearly changes with age increase. Presumably, it may improve during the prime of life and start to decline just after a certain stage. This work demonstrates that age growth is not directly conjugated with the organism fading and pathology development. Oppositely, vitality and resistance to xenobiotics may even improve with age at least until the prime of life.

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Section: Discussionmentioning

confidence: 99%

Neurotoxicity of Silver Nanoparticles and Non-Linear Development of Adaptive Homeostasis with Age

et al. 2023

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Nanoparticles and nanomaterials as inevitable modern toxic agents. Review. Part 1. Application of nanoparticles and occupational nanotoxicology

Ivlieva¹,

Petritckaya²,

Рогаткин

et al. 2022

Ekologiya cheloveka (Human Ecology)

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Almost every person in all spheres of activity is in contact with nanoparticles (NPs) in the developed countries of the world. The use of NPs in medicine, in everyday life, in the food industry, and in many other areas is expanding. Therefore, in the 2010s, a new scientific direction - nanosafety - developed very actively. The consequences of contact with NPs for cells and tissues - inflammation, development of oxidative stress, disruption of the DNA structure, apoptosis, disruption of the functioning of tissues and organs - have already been studied quite well within the framework of the study of molecular and cellular toxicity. NPs with waste and emissions enter the air, water, soil and from them into living organisms. The impact of NPs on ecosystems is assessed in studies of the toxicity of NPs to the environment. NPs pose a significant danger to workers in production, where contact with NPs can be very long and chronic. In occupational pathology, data is already accumulating on NP-induced health problems and associated risk factors in workers in the nanotechnology industry. Due to the abundance of NPs in human life, expectant mothers and young children inevitably come into contact with them, therefore, the study of the influence of NPs on the intrauterine and early development of offspring is an important area of research. The brain is a particularly vulnerable place for exposure to NPs due to their ability to cross the blood-brain barrier. Evidence of disturbances in the structure and functions of the brain in both adults and young animals is found in all areas of research into the toxicity of NPs. Methods for assessing various aspects of behavior, based on various brain functions, including cognitive ones, made it possible to obtain a clear idea of the often negative consequences of contact with NPs for higher nervous activity. All these results are described in detail and systematically in the presented review. However, there is still considerable room for further research. In a number of studies, the toxic effect of NPs is not detected, and what affects its absence is not clear. Can these situations be used to protect against the toxic effects of NPs? These and other unresolved issues are also discussed in the review.

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Nanoparticles and nanomaterials as inevitable modern toxic agents. Review. Part 2. Main areas of research on toxicity and techniques to measure a content of nanoparticles in tissues

Ivlieva¹,

Zinicovscaia²,

Petritskaya³

et al. 2022

Ekologiya cheloveka (Human Ecology)

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This second part of the review considers the following three main areas of research on the toxicity of nanoparticles (NPs): toxicity of environmental NPs, molecular mechanisms of toxicity, and the reproductive toxicity. The main methods for the quantitative measurements of the content of NPs in biological samples are also considered as the necessary stage of research on the toxicity of NPs for humans and animals.

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Unexpected Reproductive Effect of Prolonged Oral Administration of Silver Nanoparticles in Laboratory Mice

Cited by 4 publications

References 20 publications

Neurotoxicity of Silver Nanoparticles and Non-Linear Development of Adaptive Homeostasis with Age

Neurotoxicity of Silver Nanoparticles and Non-Linear Development of Adaptive Homeostasis with Age

Nanoparticles and nanomaterials as inevitable modern toxic agents. Review. Part 1. Application of nanoparticles and occupational nanotoxicology

Nanoparticles and nanomaterials as inevitable modern toxic agents. Review. Part 2. Main areas of research on toxicity and techniques to measure a content of nanoparticles in tissues

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