Unibody core–shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging

Ho, Lin‐Chen; Hsu, Chao-Hsiung; Ou, Chung-Mao; Wang, Chia‐Wei; Liu, Tsang-Pai; Hwang, Lian‐Pin; Lin, Yung‐Ya

doi:10.1016/j.biomaterials.2014.10.006

Cited by 27 publications

(13 citation statements)

References 47 publications

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“…MR nano-theranostic hyperthermia uses nontoxic, biocompatible magnetic nanoparticles to target and accumulate at the lesions to generate enhanced contrast for early lesion detection and generate heat to kill lesion cells directly through hyperthermia or indirectly through thermal activation and control releasing of drugs. [34][35][36][37][38] By considering the effects of magnetic nanoparticle aggregation on MR nano-theranostic hyperthermia, our revised cluster-based model provides a more accurate prediction of experimental values, as shown in Figures 3-6 for magnetite Fe 3 O 4 and cobalt ferrite CoFe 2 O 4 magnetic nanoparticles. The aggregation of magnetic nanoparticles increases the cluster magnetic anisotropy while reducing both the cluster domain magnetization and the average magnetic moment, which, in turn, decreases the imaginary part of the magnetic susceptibility to shift the predicted SLP toward smaller magnetic nanoparticle diameter with lower peak values.…”

Section: Resultsmentioning

confidence: 99%

Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia

Wang¹,

Hsu²,

Li³

et al. 2017

IJN

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Magnetic resonance (MR) nano-theranostic hyperthermia uses magnetic nanoparticles to target and accumulate at the lesions and generate heat to kill lesion cells directly through hyperthermia or indirectly through thermal activation and control releasing of drugs. Preclinical and translational applications of MR nano-theranostic hyperthermia are currently limited by a few major theoretical difficulties and experimental challenges in in vivo conditions. For example, conventional models for estimating the heat generated and the optimal magnetic nanoparticle sizes for hyperthermia do not accurately reproduce reported in vivo experimental results. In this work, a revised cluster-based model was proposed to predict the specific loss power (SLP) by explicitly considering magnetic nanoparticle aggregation in in vivo conditions. By comparing with the reported experimental results of magnetite Fe3O4 and cobalt ferrite CoFe2O4 magnetic nanoparticles, it is shown that the revised cluster-based model provides a more accurate prediction of the experimental values than the conventional models that assume magnetic nanoparticles act as single units. It also provides a clear physical picture: the aggregation of magnetic nanoparticles increases the cluster magnetic anisotropy while reducing both the cluster domain magnetization and the average magnetic moment, which, in turn, shift the predicted SLP toward a smaller magnetic nanoparticle diameter with lower peak values. As a result, the heating efficiency and the SLP values are decreased. The improvement in the prediction accuracy in in vivo conditions is particularly pronounced when the magnetic nanoparticle diameter is in the range of ~10–20 nm. This happens to be an important size range for MR cancer nano-theranostics, as it exhibits the highest efficacy against both primary and metastatic tumors in vivo. Our studies show that a relatively 20%–25% smaller magnetic nanoparticle diameter should be chosen to reach the maximal heating efficiency in comparison with the optimal size predicted by previous models.

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Section: Resultsmentioning

confidence: 99%

Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia

Wang¹,

Hsu²,

Li³

et al. 2017

IJN

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“…Stimuli-responsive materials have attracted considerable interest due to their potential usage in various devices in the mechanical, biomedical and robotic elds, such as sensors, dampers, actuators, switches, valves, articial muscles, and controlled drug delivery systems. [1][2][3][4][5] Existing research mainly focuses on precisely controllable responses to external stimuli, including temperature, pH, light, and electric or magnetic elds. [6][7][8][9] Electroresponsive materials are mostly made up of electrically polarizable particles, which behave as electric dipoles that can be polarized and attract or repel each other to form solid-like chains in the presence of an external electric eld, and this is reversibly controlled.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and excellent electroresponsive properties of ideal PMMA@BaTiO₃ composite particles

et al. 2019

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“…11 In our previous work, we developed magnetic resonance nanotheranostic hyperthermia using nontoxic, biocompatible magnetic nanoparticles to target and accumulate at the lesions to generate enhanced contrast for early lesion detection and generate heat to kill lesion cells directly through hyperthermia or indirectly through thermal activation and control releasing of drugs. [38][39][40][41][42][43] In this study, instead of focusing on producing a direct cell-killing effect, hyperthermia treatment serves to induce the antitumor immune system activated by the extracellular HSPs released from the heat-treated necrotic tumor cells. Such immunity is expected to detect and attack all metastases.…”

Section: Resultsmentioning

confidence: 99%

Nano-therapeutic cancer immunotherapy using hyperthermia-induced heat shock proteins: insights from mathematical modeling

Lin¹,

Hsu²,

Lin³

2018

IJN

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BackgroundNano-therapeutic utilizing hyperthermia therapy in combination with chemotherapy, surgery, and radiation is known to treat various types of cancer. These cancer treatments normally focus on reducing tumor burden. Nevertheless, it is still challenging to confine adequate thermal energy in a tumor and obtain a complete tumor ablation to avoid recurrence and metastasis while leaving normal tissues unaffected. Consequently, it is critical to attain an alternative tumor-killing mechanism to circumvent these challenges. Studies have demonstrated that extracellular heat shock proteins (HSPs) activate antitumor immunity during tumor cell necrosis. Such induced immunity was further shown to assist in regressing tumor and reducing recurrence and metastasis. However, only a narrow range of thermal dose is reported to be able to acquire the optimal antitumor immune outcome. Consequently, it is crucial to understand how extracellular HSPs are generated.Materials and methodsIn this work, a predictive model integrating HSP synthesis mechanism and cell death model is proposed to elucidate the HSP involvement in hyperthermia cancer immune therapy and its relation with dead tumor cells. This new model aims to provide insights into the thermally released extracellular HSPs by dead tumor cells for a more extensive set of conditions, including various temperatures and heating duration time.ResultsOur model is capable of predicting the optimal thermal parameters to generate maximum HSPs for stimulating antitumor immunity, promoting tumor regression, and reducing metastasis. The obtained nonlinear relation between extracellular HSP concentration and increased dead cell number, along with rising temperature, shows that only a narrow range of thermal dose is able to generate the optimal antitumor immune result.ConclusionOur predictive model is capable of predicting the optimal temperature and exposure time to generate HSPs involved in the antitumor immune activation, with a goal to promote tumor regression and reduce metastasis.

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Unibody core–shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging

Cited by 27 publications

References 47 publications

Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia

Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia

Fabrication and excellent electroresponsive properties of ideal PMMA@BaTiO₃ composite particles

Nano-therapeutic cancer immunotherapy using hyperthermia-induced heat shock proteins: insights from mathematical modeling

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Unibody core–shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging

Cited by 27 publications

References 47 publications

Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia

Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia

Fabrication and excellent electroresponsive properties of ideal PMMA@BaTiO3 composite particles

Nano-therapeutic cancer immunotherapy using hyperthermia-induced heat shock proteins: insights from mathematical modeling

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Product

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Fabrication and excellent electroresponsive properties of ideal PMMA@BaTiO₃ composite particles